Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022104 (irritable bowel syndrome)
 8,033 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Inflammatory bowel disorder is associated with certain pathophysiological disturbances which make established techniques of colon targeting more complex and inconsistent. Probable reason is severity of inflammation which leads to more variability in normal range of triggering factors that are being exploited for colon targeting. Influential changes in pathophysiology of intestine during inflammatory bowel disorder including Crohn's disease and ulcerative colitis both in active as well as quiescent stage have been discussed. Also the potential of various drug delivery techniques used both orally and rectally for site specificity have been summarized in inflammatory bowel disorder. Colon targeting surely has additional advantages in drug delivery specifically for the effective treatment of local pathologies. Colon targeting in IBD state demands exhaustive cognizance about the triggering conditions responsible for activation of drug release in IBD. Therefore despite the modern techniques exploited for colonic delivery, the effective management of IBD needs additional efforts and improvisation in developing precise colonic drug delivery system in inflamed bowel. Among all investigated techniques for colon delivery in IBD, pH based system is found to be more effective in targeting colon which has been vindicated by various clinical studies. In this review various pharmaceutical strategies have been covered which have been exploited clinically for the management of inflamed intestinal conditions.
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PMID:Current pharmaceutical strategies for efficient site specific delivery in inflamed distal intestinal mucosa. 2931 45

Colon-specific drug delivery is critical for treating diseases of colon, such as colon cancer, amoebiasis, irritable bowel syndrome, and inflammatory bowel disease. This study reviews the effects of targeted oral drug delivery on patient by measuring the accurate administration of the drug to specific disease spot, thus enhancing the therapeutic efficacy and provides better therapeutic outcomes. Medically targeted delivery to colon produces local effect on the diseases and hinders the systemic toxic effects of drugs. The delivery of therapeutics to the specific diseased part of colon has its merits over systemic drug delivery, albeit has some obstacles and problems. Colon drug delivery can be used to create both systemic and local effects. Many advanced approaches are used, such as conventional methods for drug release to colon, delayed release dosage forms, nanoparticles, carbon nanotubes, dendrimers, and alginate coated microparticles. This concise review summarizes and elaborates the details of different techniques and strategies on targeted oral drug delivery to colon as well as studies the advantages, disadvantages, and limitations to improve the application of drug in the part of the affected colon.
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PMID:Advances in orally targeted drug delivery to colon. 3133 90


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