Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0021933 (
intussusception
)
3,822
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
AIR
is an excellent example of the application of the scientific process to the treatment of pediatric disease. For more than 40 years, pediatric radiologists in North America were comfortable with hydrostatic enemas for the diagnosis and treatment of
intussusception
. Initial clinical trials in the 1980s suggested the efficacy of
AIR
. Subsequent clinical studies demonstrated that fluoroscopy time and radiation are less, accurate pressure measurements are possible, and reduction rates are higher with
AIR
than with hydrostatic techniques. Questions regarding safety and types of perforation were answered in the laboratory with an animal model. Moreover, this experimental work clarified issues regarding maximum pressures and the importance of the Valsalva maneuver during
AIR
. Experimental data has been transferred to the radiological treatment of childhood
intussusception
. The "winds of change", generated by clinical and basic research, have now swept across North America. More and more radiologists are performing
AIR
. Many of the pediatric radiologists who still doubt the efficacy of
AIR
have had no experience with the technique. Air insufflation is safe and effective for the diagnosis and treatment of
intussusception
in infants and children. It is replacing the hydrostatic enema in an ever-increasing number of institutions.
AIR
is quicker, safer, and more effective than hydrostatic enemas. If you are using
AIR
, I hope this overview will further improve the radiological care of your pediatric patients. If you are not using
AIR
, I hope that these personal observations will stimulate your interest. "Try it; you'll like it!"
...
PMID:Air intussusception reduction: "the winds of change". 756 52