Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0021933 (intussusception)
 3,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Malignant melanoma metastases to the GIT are not uncommon, and often the diagnosis is delayed. Within the GIT, the small bowel is most frequently involved, followed by the stomach, large bowel, and esophagus. Patients with acute complications such as bleeding, perforation, intussusception, and obstruction require urgent surgical intervention. The diagnosis of metastatic melanoma is pathologically confirmed at surgical exploration in 80% of patients, by endoscopic procedures in 15%, and percutaneous biopsy in 5%. Small or large bowel resection for hemorrhage or obstruction provides symptomatic relief in 79-92% of patients with a postoperative mortality rate of 5%. Reported 1- and 5-year survival rates are 44% and 9-19%, respectively. Because of the acceptable morbidity in select symptomatic patients, surgical palliation should be undertaken when the quality of life may be improved. Malignant metastatic melanoma involving the GIT has a dismal prognosis. The symptoms are commonly nonspecific and not recognized antemortem. Gut metastases signify an advanced stage of disease. Chemotherapy and immunotherapy have been ineffective in prolonging survival for these patients. For patients with general good health and symptomatic metastases, their disease can be excised with limited morbidity and mortality while providing effective and lasting palliation. Because of this, surgical resection is warranted in many patients with symptomatic gastrointestinal metastases from melanoma.
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PMID:Metastatic melanoma of the gastrointestinal tract: a review of the literature. 813 14

Intussusception in adults is a rare cause for intestinal obstruction and is usually secondary to some lesion in the gastrointestinal tract GIT. We report a case of intestinal obstruction due to ileo-colic intussusception; an inflammatory fibroid polyp formed the leading edge of the intussusceptum, which is a rare polypoidal lesion of the GIT.
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PMID:Inflammatory fibroid polyp of the ileum causing intussusception. 1598 92

A 55 years old male was admitted in the surgical unit of Dhaka Medical College & Hospital with the complaints of pain and discomfort in the upper abdomen for 1 day and hiccough and vomiting for several episodes for same duration. He had history of abdominal operation 10 years back for his peptic ulcer disease probably due to pyloric stenosis. On examination a linear scar mark was present along the upper midline region & visible peristalsis was seen on the left hypochondriac region. A palpable diffuse lump was present in the left hypochondriac region which was intraperitoneal seemed to be distended gut and the peristaltic wave moved from left to right. Endoscopy of upper GIT Showed loops of small intestine (evidenced by valvulae conneventes) protruded through a stoma suggestive of jejunogastric intussusception. Laparotomy revealed a portion of adherent small gut already become gangrenous so the whole portion of the intussuscepted gut was resected. After that revision and take-down of the anastomosis was done with vicryl stitches. The post operative period was uneventful. The patient underwent regular follow up.
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PMID:Acute abdomen 10 years after surgery for duodenal ulcer disease. 2256 82