Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0021933 (intussusception)
 3,822 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Forty patients with colorectal schistosomiasis who failed to respond to medical therapy were studied. They had dysentery with bloody mucus and anemia, polyps, pericolic masses, and schistosomal ulcers. Two patients had cecal masses which appeared to be intussusception and appendicitis. Three patients had chronic intestinal obstruction. Diverting transverse colostomy, followed by other surgical procedures, is the safest method of management.
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PMID:Colorectal schistosomiasis: clinicopathologic study and management. 49 94

We describe the clinical course and outcome of Rwandan refugees with cholera-like illness (n = 567) and clinical dysentery (n = 1,062) treated at the Israeli Army field hospital in the disaster region of Goma, Zaire, during the summer of 1994. Vigorous fluid administration was the primary therapy, complemented with antibiotics for patients with presumed Shigella infection. Recovery rates were 94% and 96% for patients with cholera and dysentery, respectively. Mortality was substantially affected by comorbid conditions such as pneumonia and meningitis, which occurred in one-quarter of these patients. Infective, metabolic, and surgical complications (including three cases of intussusception) may have contributed to the deaths. The outcome of patients during diarrheal epidemics of cholera or bacillary dysentery may be favorable, even in disaster settings, if patients are evacuated promptly to medical facilities and appropriate therapy is instituted. We close with general observations on procedures to be followed in future epidemics of diarrheal diseases.
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PMID:Diarrheal epidemics among Rwandan refugees in 1994. Management and outcome in a field hospital. 945 70

Throughout the 1960s and 1970s, pigbel (enteritis necroticans) was the most common cause of death in children over the age of 1 year in hospitals in the highlands of Papua New Guinea (PNG). There has been recent widespread perception that after the successful vaccination program in the 1980s the disease virtually disappeared. A new vaccine is now available, but disease burden information is conflicting: despite almost no pigbel being reported from major hospitals there have been many reports of the disease from outlying health centres. This study aimed to provide information on the disease burden of pigbel in PNG, so that appropriate vaccine policy decisions could be made. We conducted a 12-month prospective study of all cases of acute abdomen in children presenting to 38 health facilities, 29 health centres and 9 hospitals in the highlands. Children were eligible for inclusion if they were aged 1-12 years and had abdominal pain of less than 2 weeks' duration. A standardized case definition of pigbel was used to distinguish cases of acute abdominal pain very likely to be due to pigbel from cases very likely to be accounted for by other diagnoses (such as gastroenteritis, typhoid, dysentery, intussusception, urinary tract infection and others). A total of 119 cases of acute abdomen were reported from 17 of the 38 health facilities involved. Of these 119 cases 11 met the criteria for pigbel and a further 8 were probable cases. There were 4 deaths among the 119 children with acute abdomen: 2 from definite pigbel, 1 from probable pigbel and the other due to complications of measles. In 2002 pigbel was the cause of between 9% and 16% of presentations with acute abdominal pain in children in the PNG highlands. The overall disease burden of pigbel was relatively small (19 definite or probable cases and 3 deaths in 12 months). However, there was substantial geographical clustering of cases: more than 50% of the definite cases occurred in children living within three electorates on the Western Highlands-Enga provincial border, no more than 40 km from each other. This study will be useful in planning pigbel vaccine policy and future surveillance.
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PMID:In search of pigbel: gone or just forgotten in the highlands of Papua New Guinea? 1645 95

It has been shown that a lytic fluid for dysentery bacilli can be obtained from the peritoneum of the guinea pig by intraperitoneal inoculation of live dysentery bacilli, and that the lytic action of such a fluid is not strictly specific, but that it exerts a group action on the dysentery-colon-typhoid group of bacilli. A lytic fluid with similar effects was obtained from a child dying of Flexner dysentery infection, and an anti-colon bacillus lytic fluid from a child who died of intussusception with colon bacillus peritonitis. The action of the lytic fluid on the dysentery bacilli, both in vivo and in vitro, is to divide the culture into sensitive and resistant strains, and the latter can be carried to a degree of very marked, if not complete resistance to lysis. Such resistant strains are not lysogenic, nor are they agglutinable. The sensitive strains are lysogenic and agglutinable. Varying degrees of sensitive and resistant bacilli exist in a single culture. The sensitive bacilli gradually lose the lysogenic property which they acquired under special conditions, but the very resistant bacilli never acquire that property. It is conceivable that the resistant strains are responsible for the untoward outcome of disease in human beings. Theoretically the administration of lytic fluid should rid the intestinal tract of most of the infecting bacilli, and only if completely resistant bacilli in large numbers remain unacted on is the outcome of the disease a fatal one.
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PMID:STUDIES ON THE PHENOMENON OF D'HERELLE WITH BACILLUS DYSENTERIAE. 1986 72