Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0021843 (bowel obstruction)
 9,927 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The records of 532 patients with advanced ovarian cancer during March 1977 to February 1993 were retrospectively reviewed. Fifty-seven cases developed intestinal obstruction, and 54 cases died of this complication. The median survival period for all patients with obstruction was 110 days, and only 5 cases survived for more than one year. Twenty-three cases were treated mainly by surgery, 18 by chemotherapy, and 16 by conservative measures. The median survival periods for each group was 96 days, 120 days, and 81 days, respectively. Their survival times are not statistically different (P > 0.05). Of the patients surgically treated, 61% (14/23) benefited from operation, 26% (6/23) had inoperable disease at laparotomy, and 9% (2/23) developed fatal surgical complications. Even though the response rate in patients receiving chemotherapy was much higher than in those surgically treated (P < 0.05), the effect of chemotherapy was just temporary, and occurred only in patients who had never been treated with high dose PDD-based regimens. In this report, the individualized management of intestinal obstruction induced by ovarian cancers is suggested, and indications and contraindications for three treatment modalities are proposed.
 ...
PMID:[Management of intestinal obstruction in advanced ovarian cancer an analysis of 57 cases]. 765 86

Desmoplastic small round cell tumors (DSRCT) are highly aggressive tumors typically involving the serosal surfaces of the peritoneum. Patients often present with abdominal pain, an abdominal mass, ascites or signs of intestinal obstruction. Cytogenetic and molecular studies have identified a characteristic t(11;22)(p13;q12) translocation within the tumor cells. The fused gene product apparently aligns the NH2-terminal domain (NTD) of the EWS gene to the zinc finger DNA-binding domain of the WT1 gene. This product could lead to loss of the tumor suppressor effect of the WT1 gene as well as to an increase in EWS driven expression of growth factors normally repressed by WT1. We investigated this latter possibility by performing immunohistochemical studies on formalin fixed tissue from 10 cases of DSRCT and five Wilms' tumors using-antibodies to insulin-like growth factor (IGF)-II, the latency associated peptide of transforming growth factor (TGF)-beta 1, platelet-derived growth factor (PDGF)-AB chain and PDGF-alpha receptor, respectively. In general, tumor cells were strongly positive for these growth factors in DSRCT, while stromal cells were negative for IGF-II and positive for the other growth factors in parallel with the tumor cells. Wilms' tumor cells were essentially negative for PDGF-AB chains, but positive for IGF-II, and the latency associated peptide of TGF-beta 1 and variably positive for PDGF-alpha receptor. These findings support the proposed molecular mechanism of tumorigenesis for DSRCT and may help explain this tumor's poor prognosis.
 ...
PMID:Intra-abdominal desmoplastic small round cell tumor: immunohistochemical evidence for up-regulation of autocrine and paracrine growth factors. 984 6