Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0021843 (
bowel obstruction
)
9,927
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Peutz-Jeghers syndrome is an autosomal dominant condition leading to gastrointestinal polyps which often causes
bowel obstruction
. This syndrome also predisposes to gastrointestinal, pancreatic, breast, uterine and other malignancies. Prognosis is likely to be improved by the early commencement of appropriate surveillance programs. Diagnostic and predictive genetic testing is now possible in many families due to identification of causative mutations in the
serine/threonine kinase
(
STK
)-11 (also known as the LKB1) gene. Such testing has now entered routine clinical practice and will allow early recognition of the condition in young, at-risk family members.
...
PMID:Peutz-Jeghers syndrome: genetic screening. 1293 63
