Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0021843 (
bowel obstruction
)
9,927
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The tight junction protein
claudin-2
is upregulated in inflammatory bowel disease, and yet its deficit worsens infectious and chemical colitis. In this issue of the JCI, Raju and Shashikanth et al. examined the contribution of
claudin-2
to immune-mediated colitis. The authors used transgenic mouse models to show that
claudin-2
deficiency attenuated colitis progression as well as a leak barrier defect, albeit at the risk of
intestinal obstruction
. Further, inhibition of
claudin-2
by targeting casein kinase 2 (CK2) also ameliorated colitis. The findings reveal unsuspected links between the pore and leak pathways of intestinal permeability and immune responses leading to colitis. They additionally suggest potential targets for therapeutic intervention in inflammatory bowel disease.
...
PMID:Claudin-2 pore causes leak that breaches the dam in intestinal inflammation. 3283 Dec 94
