Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0021831 (enteropathy)
 4,403 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report three cases of enteropathy associated with systemic sclerosis that were improved with oral type II collagen. The first patient, who was diagnosed as having systemic sclerosis-polymyositis overlap syndrome at the age of 35, was hospitalized for treatment of renal crisis at the age of 36. He acquired severe enteropathy associated with systemic sclerosis. The renal crisis was improved with angiotensin-converting enzyme inhibitor, but enteropathy persisted. He was given type II collagen in order to treat ileus. Four weeks later, ileus was improved and he was able to take foods. The second patient, a 63-year-old female whose onset of systemic sclerosis was at the age of 58, complained of ileus several times and was given oral type II collagen. Six weeks later, ileus was improved. The third patient, a 19-year-old female, was diagnosed as having systemic sclerosis-polymyositis overlap syndrome. Enteropathy was so severe that she could not take foods for 1 year. She was given oral type II collagen. Six months later, ileus and skin sclerosis were markedly improved. These results suggest that oral type II collagen is effective in the treatment of gastrointestinal dysfunction associated with systemic sclerosis.
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PMID:[Three cases of systemic sclerosis-associated gastrointestinal dysfunction that were improved with oral bovine type II collagen]. 1112 60

Autoantibodies to autoimmune enteropathy-related 75 kDa antigen (AIE-75) and villin are disease markers of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome which is characterized by a peripheral tolerance defect. On the other hand, anti-tryptophan hydroxylase-1 (TPH-1) antibodies are detected in autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy (APECED), a central tolerance defect, especially when complicated with gastrointestinal dysfunction. However, to date, anti-AIE-75 and anti-villin antibodies or anti-TPH-1 antibodies have not been tested in APECED or IPEX syndrome, respectively. In the present study, we confirmed the disease specificity of both anti-AIE-75 and anti-TPH-1, although anti-villin antibodies were detected in some patients with APECED. Our observation suggests that immunotolerance to AIE-75 depends on the peripheral mechanism, whereas the tolerance to TPH-1 depends on the central mechanisms.
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PMID:Disease specificity of anti-tryptophan hydroxylase-1 and anti-AIE-75 autoantibodies in APECED and IPEX syndrome. 2546 30

In addition to drugs approved by the US Food and Drug Administration (FDA) that treat, cure, or mitigate disease, medical foods are a tool to help manage chronic conditions and diseases. A medical food, according to the FDA, is a food that is developed to be eaten or administered enterally under the guidance of a physician and that is meant for the specific dietary management of a condition or disease for which distinctive nutritional requirements, based upon known scientific principles, are established by medical evaluation. A variety of medical foods exist to help manage a wide range of medical conditions, from Alzheimer disease to HIV-associated enteropathy. EnteraGam contains serum-derived bovine immunoglobulin/protein isolate, which has been studied extensively in diarrhea-predominant irritable bowel syndrome, inflammatory bowel disease (IBD), and HIV-associated enteropathy. VSL#3 is a probiotic that is used in pouchitis for patients with ulcerative colitis as well as irritable bowel syndrome. Modulen IBD is a whole-protein, sole-nutrition formulation used to manage the active phase of Crohn's disease. Vivonex is an elemental diet that is used in a variety of diseases associated with severe gastrointestinal dysfunction. Medical foods are safe and must have proven efficacy in helping to manage a variety of gastrointestinal conditions and diseases. These therapies represent tools that can be used prior or in addition to traditional medical therapies. This article discusses the history and development of medical foods under the FDA and concentrates specifically on medical foods used to help manage diseases of the gastrointestinal tract.
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PMID:The Emerging Therapeutic Role of Medical Foods for Gastrointestinal Disorders. 2845 Aug 17