Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0021390 (inflammatory bowel disease)
 23,302 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
gut 2848
IBD 1729
cytokine 1660
Sep 1462
TNF 1196
tumor necrosis factor 954
Mol 738
IL-6 673
IL-10 665
myeloperoxidase 575
CD4 533
IL-17 424
lymphoid 365
TNF-alpha 318
ankylosing spondylitis 311
IFN 278
lipopolysaccharide 270
IL-8 260
interferon 256
DSS 249
NOD2 247
IL-23 242
inducible nitric oxide synthase 227
ASA 222
IgA 221
IL-4 217
chemokine 209
C-reactive protein 207
IFN-gamma 188
TLR4 174
LPS 167
CD8 157
interleukin-6 154
IL-1 152
collagen 151
IL-2 150
tumor necrosis factor alpha 148
Cytokine 148
STAT3 147
HLA 141
interleukin-10 137
She 133
p65 130
HLA-B27 125
interferon-gamma 125
insulin 122
CARD15 117
COX-2 116
mucin 115
p38 114
granulocyte 109
IL-22 109
cyclooxygenase-2 106
endoplasmic reticulum 106
CD25 106
MAPK 103
Tumor necrosis factor 100
albumin 100
occludin 94
IL-18 92
hemoglobin 91
p53 88
IL-13 88
adhesion molecule 87
alkaline phosphatase 87
MRI 87
ICAM-1 84
superoxide dismutase 84
mast cell 83
nitric oxide synthase 81
caspase-3 77
NLRP3 76
lactoferrin 75
glycoprotein 75
cyclooxygenase 73
B27 72
TLR2 71
substance P 70
serum albumin 70
TCR 69
IL10 69
IgE 68
CRP 67
Pol 66
ERK 64
CD11b 63
TGF-beta 63
catalase 62
reserved 62
E-cadherin 62
ZO-1 62
ATP 62
CD14 61
IL23R 61
major histocompatibility complex 61
IL-5 60
ATG16L1 58
human leukocyte antigen 58
STAT 57
p40 55
CD40 55
catenin 55
thiopurine S-methyltransferase 54
vitamin D receptor 54
MAdCAM-1 54
thymus 53
GSH 52
Janus kinase 52
MCP-1 52
interleukin-2 51
JNK 51
TNF receptor 51
NOD 50
T cell receptor 50
PI3K 49
lysozyme 48
CD11c 48
thiopurine methyltransferase 48
GM-CSF 48
TL1A 47
interferon gamma 46
SARS 45
IL-1 beta 44
IL-33 44
B12 44
ERK1 44
THP 44
erythroid 43
CXCL10 43
HLA-DR 41
interleukin-17 41
STAT1 41
chemokine receptor 41
vascular endothelial growth factor 41
nuclear receptor 41
ferritin 40
intercellular adhesion molecule-1 40
IL-21 40
MHC 40
growth hormone 40
P-glycoprotein 39
histone 39
claudin-2 38
MyD88 38
mTOR 38
vascular cell adhesion molecule-1 38
defensin 38
fibrinogen 38
IL-17F 38
interleukin 10 38
ROS 37
P-selectin 37
CD103 37
mitogen-activated protein 37
transferrin 37
glucagon 36
lectin 36
APC 36
5-lipoxygenase 36
CXCL1 36
more...
Disease
inflammatory bowel disease 23302
Crohn's disease 6899
ulcerative colitis 6478
colitis 4575
irritable bowel syndrome 2299
cancer 2035
rheumatoid arthritis 1136
colorectal cancer 1089
tumor 740
arthritis 662
psoriasis 608
Colitis 555
primary sclerosing cholangitis 491
diabetes 482
colon cancer 467
celiac disease 458
dysplasia 446
multiple sclerosis 443
obesity 440
asthma 431
Inflammatory Bowel Disease 392
enteropathy 385
carcinoma 375
ankylosing spondylitis 343
systemic lupus erythematosus 332
anemia 287
carcinogenesis 270
depression 261
autoimmune disease 260
pyoderma gangrenosum 250
DSS 249
DSS 249
infectious diseases 239
sepsis 239
malnutrition 237
liver disease 232
sepsis 229
psoriatic arthritis 223
vasculitis 214
tuberculosis 212
lymphoma 212
Colon 210
Colon 210
Colon 210
malabsorption 200
tumorigenesis 194
atherosclerosis 192
hepatitis 191
gastrointestinal disease 191
chronic disease 189
osteoporosis 187
cirrhosis 184
pancreatitis 181
immunodeficiency 180
Crohn's colitis 177
adenocarcinoma 176
cholangitis 169
skin disease 168
ileitis 165
uveitis 150
HIV 149
ischemia 148
cytomegalovirus 144
diverticular disease 142
cardiovascular disease 140
diverticulitis 139
type 1 diabetes 136
adenoma 132
Mycobacterium 130
Clostridium difficile infection 127
enteritis 126
HLA-B27 125
bowel obstruction 123
enterocolitis 122
Best 119
metabolic syndrome 119
cystic fibrosis 105
sarcoidosis 103
type 2 diabetes 100
proctitis 100
hypertension 98
graft-versus-host disease 96
pneumonia 93
polyposis 93
erythema nodosum 90
iron deficiency 88
Rectum 87
Rectum 87
Rectum 87
Rectum 87
gastritis 86
Epstein 85
lupus 84
infectious colitis 83
systemic disease 81
stroke 80
ischemic colitis 79
chronic obstructive pulmonary disease 79
gastroenteritis 78
iron deficiency anemia 78
necrotizing enterocolitis 77
hepatitis B 76
spondyloarthropathy 76
sacroiliitis 74
virus infection 74
atopic dermatitis 74
peptic ulcer 73
megacolon 73
primary biliary cirrhosis 72
Alzheimer's disease 72
Parkinson's disease 71
vitamin D deficiency 70
eosinophilia 70
enthesitis 69
acute pancreatitis 69
chronic pancreatitis 69
lupus 68
Infection 68
appendicitis 68
regional enteritis 67
leukemia 67
amyloidosis 66
short bowel syndrome 65
thrombocytopenia 64
gastroesophageal reflux disease 64
encephalomyelitis 63
gallstones 62
dyspepsia 62
metastases 62
immunopathology 61
rash 60
pruritus 60
AIDS 60
arthropathy 59
anterior uveitis 58
cholestasis 58
Barrett's esophagus 57
SCID 57
heart failure 57
SARS 56
familial adenomatous polyposis 56
melanoma 56
renal disease 54
fatty liver 54
skin cancer 54
rare disease 53
acne 53
esophagitis 53
autism 53
Sweet 52
gastric cancer 52
tumor progression 52
GSH 52
food allergy 52
dermatitis 51
NOD 50
rectal cancer 50
bacterial infection 49
Helicobacter pylori infection 49
chronic hepatitis 49
more...
Symptom
diarrhea 1321
abdominal pain 516
pain 417
vomiting 130
fatigue 124
constipation 104
nausea 85
anorexia 69
arthralgia 52
erythema 49
headache 48
discomfort 45
discomfort 44
anesthesia 43
back pain 42
splenomegaly 39
bloating 38
seizures 36
chest pain 33
weakness 30
Ill 28
colic 28
dyspnea 27
cough 26
intestinal bleeding 25
stigma 25
acute abdomen 23
low back pain 22
cachexia 22
hepatomegaly 22
microbial colonization 20
Gastrointestinal symptoms 20
abdominal discomfort 20
chronic constipation 19
Wind 19
overweight 19
nausea and vomiting 18
respiratory distress 17
tenesmus 16
fever of unknown origin 16
analgesia 15
lethargy 15
collapse 15
myalgia 15
clubbing 12
alexithymia 11
acute abdominal pain 11
shortness of breath 11
hepatosplenomegaly 10
dizziness 10
ataxia 9
epigastric pain 9
starvation 9
pelvic pain 9
thinning 8
Visceral pain 8
flushing 8
Chronic abdominal pain 8
abdominal cramps 7
sore throat 7
acute stress 7
decreased appetite 7
dry eye 6
chills 6
acute pain 6
chronic cough 6
productive cough 6
heartburn 6
hypothermia 5
angina 5
hypoproteinemia 5
right lower quadrant pain 5
Musculoskeletal symptoms 5
chronic back pain 5
paresthesia 5
pneumaturia 5
rectal pain 5
insomnia 5
exertional dyspnea 5
anal pain 5
blurred vision 5
syncope 5
sleepiness 5
right upper quadrant pain 4
asthenia 4
flank pain 4
change in stool 4
pallor 4
halitosis 4
renal colic 4
regurgitation 4
belching 4
bone pain 4
Functional abdominal pain 4
hoarseness 4
tremor 4
vertigo 4
pleuritic chest pain 4
non-productive cough 3
cancer pain 3
hyperemesis 3
Depressive symptoms 3
lassitude 3
HSA 3
hypotonia 3
spasticity 3
night sweats 3
cerebellar ataxia 3
knee pain 3
functional recovery 3
stomach pain 3
neck pain 3
acidity 3
sneezing 3
hip pain 3
intestinal pain 3
hyperemesis gravidarum 3
exhaustion 3
livedo 3
swollen joints 3
dysarthria 3
generalized abdominal pain 2
Poor sleep 2
agitation 2
dysuria 2
urinary frequency 2
leg pain 2
photophobia 2
emaciation 2
groin pain 2
koilonychia 2
adenitis 2
Chronic pelvic pain 2
paresis 2
cyanosis 2
loss of balance 2
Flare 2
heel pain 2
Gastrointestinal signs and symptoms 2
hemiplegia 2
spasm 2
tachypnea 2
left upper quadrant pain 2
distraction 2
masculinization 2
wheezing 2
polydipsia 1
dystonia 1
inanition 1
apathy 1
forgetfulness 1
skin damage 1
loin pain 1
eds 1
hypertonia 1
hopelessness 1
excessive sweating 1
breath holding 1
periorbital edema 1
jaw pain 1
more...
Drug
Dermatol 219
Infliximab 193
Infliximab 193
IFN-gamma 179
IL-2 152
Bifidobacterium 111
Mesalazine 67
CSF 55
Budesonide 46
Adalimumab 38
ROS 37
lysine 35
lactose 34
Sulphasalazine 29
Monit 28
IL-11 26
ascorbate 26
Dextran sulfate sodium 25
Prednisolone 23
Retinoic acid 22
Asthma 22
G-CSF 21
Rifaximin 18
Natalizumab 17
Tacrolimus 15
Dial 15
Cardiovasc 14
p75 14
Isotretinoin 13
Indomethacin 13
CDP 13
MAP 13
vitamin E 13
ROC 12
Histamine 12
Copaxone 11
CCL 11
Leaf 10
IL-1ra 10
niacin 9
Portal 8
GEO 8
Gastro 8
EPA 8
ampicillin 8
Asn 7
Prednisone 7
Dipentum 7
Heme 7
Rituximab 7
CAM 7
caffeine 7
Glucagon 6
Vitamin B 6
NADH 6
Mirtazapine 6
Bromelain 6
Glutathione 6
Mercaptopurine 6
Nitric Oxide 6
TAK 6
Hypaque 5
Vitamin E 5
Doxycycline 5
ICI 5
Paraffin 5
Vitamin B12 5
Hypaque 5
Gel 5
CED 5
Golimumab 5
DNase I 5
PMPA 5
Methylprednisolone 5
Ketotifen 4
ABC 4
Growth hormone 4
ACT 4
ENT 4
Rebamipide 4
Vitamin A 4
Nephron 4
ALA 4
Nephron 4
Growth hormone 4
CTX 4
Certolizumab pegol 4
Serum albumin 4
Glycyrrhiza 4
THF 4
CDX 3
Pirfenidone 3
Carbadox 3
Venofer 3
Lovastatin 3
Fluorescein 3
Rosiglitazone 3
Mutagen 3
CDX 3
Anakinra 3
Thioguanine 3
citric acid 3
Glide 2
MDS 2
Vorinostat 2
Ipilimumab 2
RFP 2
Visilizumab 2
Kenyan 2
ZnO 2
CTX 2
Antithrombin III 2
Omeprazole 2
NH3 2
Estrogens 2
Lomotil 2
Lomotil 2
Award 2
Fragment 2
Teduglutide 2
Riboflavin 2
nitroglycerin 2
Fraction 2
Ferumoxytol 2
Giardiasis 2
Rolipram 2
AGG 2
CTT 2
Tenofovir 2
Nimesulide 2
Orphan 2
Arsenic trioxide 2
Albumin 2
Aminosalicylic Acid 2
Rutin 2
Abatacept 2
CPR 2
Imiquimod 2
Cellulose acetate 2
TAT 2
Alliance 2
Zileuton 2
Clodronate 2
Bayer 2
Tocopherol 2
Ganciclovir 2
ETS 2
NVP 2
CTX 2
Neoral 2
balanced salt solution 2
Amoxicillin 2
EE2 2
Urokinase 1
9-THC 1
Zinc gluconate 1
CIA 1
Galactose 1
VCR 1
MDM 1
more...
Enzyme
peroxidase 602
mitogen-activated protein kinase 243
ERK 111
superoxide dismutase 97
thiopurine methyltransferase 88
alkaline phosphatase 87
focal adhesion kinase 82
APC 71
catalase 67
caspase-3 63
luciferase 56
caspase-1 55
protein kinase 52
NO synthase 51
NADPH oxidase 50
lysozyme 48
NADPH oxidase 45
trypsin 45
protein kinase C 40
P-glycoprotein 40
reverse transcriptase 35
calcineurin 34
MIP 33
collagenase 33
myosin light chain kinase 30
alanine aminotransferase 29
NOS 29
lipoxygenase 29
glutathione peroxidase 28
IKK 28
ACS 26
thrombin 26
ATPase 26
transglutaminase 25
proteasome 24
MEK 23
tryptase 22
phospholipase A2 22
phosphodiesterase 21
elastase 21
caspase-8 20
AMP-activated protein kinase 20
lactate dehydrogenase 18
lactase 18
aspartate aminotransferase 18
meprin 17
glutathione S-transferase 16
MMP 16
kallikrein 15
neutrophil elastase 15
phosphatidylinositol 3-kinase 14
CYP3A4 14
PARP 14
guanylate cyclase 14
phospholipase C 14
MMP-3 14
arginase 14
xanthine oxidase 14
sucrase 13
ACE 13
MAP 13
gamma-glutamyl transpeptidase 13
caspase-9 11
cathepsin G 11
heme oxygenase 10
lipase 10
BBE 10
dipeptidyl peptidase IV 10
TACE 10
granzyme B 10
AMPK 9
chitinase 9
thromboplastin 9
RNA polymerase 9
prolyl hydroxylase 9
urease 9
sphingosine kinase 9
urease 9
CD10 9
AMPK 9
tissue plasminogen activator 8
sucrase-isomaltase 8
phosphoinositide 3-kinase 8
glyceraldehyde-3-phosphate dehydrogenase 8
creatine kinase 8
glucose-6-phosphatase 8
chymase 8
proteinase-3 8
methylenetetrahydrofolate reductase 7
methylenetetrahydrofolate reductase 7
GSK 7
transcriptase 7
NQO1 7
pepsin 7
acid phosphatase 7
glyceraldehyde-3-phosphate dehydrogenase 7
renin 7
ornithine decarboxylase 7
LPL 7
indoleamine 2,3-dioxygenase 7
invertase 7
plasmin 6
urokinase-type plasminogen activator 6
glyceraldehyde-3-phosphate dehydrogenase 6
hypoxanthine-guanine phosphoribosyltransferase 6
bromelain 6
aldehyde dehydrogenase 6
adenosine deaminase 6
AST 6
tissue kallikrein 6
glutathione reductase 6
adenosine deaminase 6
alpha-glucosidase 5
azoreductase 5
protein phosphatase 2A 5
chymotrypsin 5
diamine oxidase 5
15-hydroxyprostaglandin dehydrogenase 5
matrix metalloproteinase 9 5
glyceraldehyde-3-phosphate dehydrogenase 5
tryptophan hydroxylase 5
beta-glucuronidase 5
prostate-specific membrane antigen 5
glyceraldehyde-3-phosphate dehydrogenase 5
ceruloplasmin 5
bile salt hydrolase 5
angiotensin-converting enzyme 2 5
hyaluronidase 5
NPL 5
neuraminidase 4
DNA methyltransferase 4
PTA 4
RNase 4
CD13 4
acetylcholinesterase 4
gamma-glutamylcysteine synthetase 4
RNase 4
MDP 4
pyruvate kinase 4
pyruvate dehydrogenase 4
DNase 4
choline acetyltransferase 4
hyaluronidase 4
15-lipoxygenase 4
thyroid peroxidase 4
Thy1 4
deoxyribonuclease 4
TSP-1 4
prostate-specific antigen 4
fragilysin 4
aldehyde dehydrogenase 4
caspase-4 3
beta-glucosidase 3
isocitrate dehydrogenase 3
adenylate cyclase 3
isocitrate dehydrogenase 3
caspase-11 3
caspase-4 3
inosine triphosphatase 3
diaphorase 3
more...
Compound
Clin 2413
Dec 1515
sodium 1493
sulfate 1236
TNF 1196
DNA 616
water 538
oxygen 417
DSS 252
calcium 243
nitric oxide 237
ASA 234
iron 226
vitamin D 211
barium 160
phosphate 159
ethanol 142
glucose 128
acetate 128
acetic acid 126
Sulfasalazine 102
Azathioprine 100
zinc 97
nitrogen 86
arginine 79
leucine 66
hydrogen 66
ATP 63
Vitamin D 61
salt 61
serine 60
His 59
ANCA 58
tyrosine 58
Mesalamine 57
GSH 56
tryptophan 56
PGE2 56
GSH 56
tryptophan 54
retinoic acid 54
tryptophan 52
tryptophan 52
galactose 51
Methotrexate 45
THP 45
creatinine 45
glutamine 45
5-HT 45
THP 44
Dextran 44
Phe 42
cysteine 41
butyric acid 39
PGE 38
PEG 38
6-Mercaptopurine 37
lysine 37
potassium 37
Curcumin 36
nitrate 35
salicylic acid 34
homocysteine 31
alanine 30
methionine 30
Cyclosporine 30
cAMP 29
CO2 29
copper 28
selenium 28
threonine 27
Ursodeoxycholic acid 27
sulfuric acid 27
ACS 26
ACS 26
Sodium 25
H2S 25
EDTA 24
EDTA 24
nicotinamide 24
Parenteral 23
urea 23
NIDA 22
Prednisolone 22
FK506 22
H2O2 22
oxalate 21
PEG 20
Optimal 20
PMA 20
Pac 19
proline 17
6-Thioguanine 17
PMA 17
NADPH 17
Sphingosine 17
SDS 17
NADPH 17
NH2 16
benzene 16
Neo 16
Tumor Necrosis Factor 16
Substance P 16
Cardiol 16
Dial 16
NAD 16
Etanercept 16
glycerol 15
Luminal 15
Leukotriene B4 15
COX 15
ASC 15
TOF 14
ANA 14
phosphorus 14
Heparin 14
ANA 14
MAP 13
MEK 13
ammonium 13
MDA 13
iodine 13
Asp 13
Indomethacin 13
MTT 13
glutamate 13
Resveratrol 13
BMC 13
Gly 13
TNB 12
ADP 12
dUTP 12
Dexamethasone 12
valine 12
neopterin 12
fluorine 12
butyric acid 12
Histamine 12
DHA 12
BMD 12
Collagen 12
glutamic acid 11
PGA 11
NAD 11
nicotinic acid 11
Nicotine 11
butyric acid 11
AMP 11
xylose 11
pyridine 10
TACE 10
Vancomycin 10
CDP 10
Adenosine 10
Lactate 10
superoxide radical 10
prostacyclin 10
Heme 10
DHA 10
Melatonin 10
more...