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Query: UMLS:C0021359 (infertility)
 26,075 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-one males with azo- or oligospermia presenting with infertility and with no evidence of organic disease were studied with luteinizing hormone - releasing hormone (LH-RH). A pituitary luteinizing hormone (LH) and follicle stimulating hormone (FSH) response was present in all cases and was normal in the majority of the subjects. Serum testosterone and 17 beta estradiol levels were normal in all cases studied. No significant correlations were found between the gonadotropin estimations and sperm count, basal serum testosterone or testosterone response to human chorionic gonadotropin. It is concluded that LH-RH is of limited diagnostic use in the investigation of this group of patients with male infertility and provides no further insight into the pathogenesis of this condition.
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PMID:Pituitary gonadotropin response to luteinizing hormone-releasing hormone (LH-RH) in males with azo- and oligospermia. 0 78

A case report of male infertility associated with testicular microlithiasis is presented. This rare condition has not previously been associated with infertility. A variable maturation arrest was observed in the spermatogenic epithelium. The question of whether the microliths are the cause of the infertility or whether both conditions are the result of some unknown agent must await further elucidation.
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PMID:Testicular microlithiasis with sterility. 0 76

In this review, the pathological findings from testicular biopsies of men suffering from various types of infertility are presented. The causes of male infertility are divided into three major categories: pretesticular, testicular, and post-testicular causes. The pre-testicular causes of infertility may be defined as extra-gonadal endocrine disorders, such as those originating in the hypothalamus, pituitary, or adrenals, which have an adverse effect on spermatogenesis. The testicular causes of infertility are primary defects of the testes. The post-testicular causes of infertility consist primarily of obstructions of the ducts leading away from the testes. Cases in which the spermatozoa are normal in number but greatly impaired in motility, presumably due to faulty maturation or improper preservation of the spermatozoa during their sojourn in the epididymides, or due to biochemical abnormalities of the seminal plasma, are also included in the postesticular category.
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PMID:Pathological aspects of the infertile testis. 3 55

Testicular biopsy has been widely used for the diagnosis of male infertility for more than three decades. During that time, with advances in cytogenetics, radioimmunoassay, and endocrinology, the role of testicular biopsy has changed. Testicular biopsy is still useful in the diagnosis of azoospermic and oligospermic males without stigmata of gonadotropic insufficiency or Klinefelter's syndrome. A classification and description is presented of pathologic changes in the testis as seen on testicular biopsy by light microscopy. The present rationale for testicular biopsy in infertility, the processing and staining of histologic material, and the role of testicular biopsy in infertility and infertility related situations, including cryptorchidism, malignant disease, and chemotherapy related changes, are discussed. Further understanding of testicular function and disease will depend upon the correlation of histologic and ultramicroscopic changes, immunohistologic localization of hormones, and epidemiologic and endocrinologic data.
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PMID:Testicular biopsy in the study of male infertility: its current usefulness, histologic techniques, and prospects for the future. 4 78

The histological evaluation of testicular biopsy in the investigation of infertility was supplemented by cytogenetic analysis of spermatogenesis in 72 patients from 1976--1978. The results show meiosis analysis to be a practical aid in the assessment of male infertility. It enables the point of interruption in the meiotic process to be accurately identified. A review of relative populations of meiotic and of interphase nuclei (the meiotic index) permits evaluation of a quantitative disturbance of spermatogenesis, a finding that is of particular value when establishing a patient's prognosis. Moreover, meiotic analysis makes it possible to recognize cytogenetic anomalies which could be responsible for the infertility state and which were chiefly seen in patients whose so-called primary infertility was hitherto classified as being of unknown origin. In two patients we thus identified a small additional chromosome in a fraction of the germinal cells, and also an abnormal pairing of all chromosomes, or the sex chromosomes alone, during the first meiotic division.
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PMID:[Value of the meiosis test in male infertility]. 4 91

A review of pharmacological therapy in male infertility shows that apart from specific therapy with gonadotropins in hypogonadotropic hypogonadism, treatment in normogonadotropic idiopathic oligozoospermia and asthenozoospermia is still empirical and often unsuccessful. Modern therapy is based on three pharmacological groups of compounds: gonadotropins, androgens and kininogenases, the latter releasing pharmacologic active kinin peptides from kininogen. In addition, antiestrogens and gonadotropin-releasing hormones seem to be promising agents for the near future. The use of antibiotics is of great importance in the therapy of male genital tract infections which often to a reduced fertility. Several other drugs (amino acids, psychopharmaceuticals, spasmolytic agents, trijodothyronine, glucocorticoids, vitamins) seem to be suitable in individuals cases, but in greater group of patients these agents do not improve fertility. Using the mentioned hormonal and nonhormonal pharmacological agents considerable progress can be demonstrated in the therapy of male infertility. However, before initiating any therapy it is important to exclude patients whose cause of infertility is untreatable or those who require surgery. Finally, it is hoped that additional progress in treatment of male infertility will soon be made possible by further improvement of fundamental research in andrology. Especially important is the development of better criteria for selection of patients for any form of therapy in order to make more specific and less empirical approaches for treatment of male infertility available.
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PMID:Recent progress in pharmacological therapy of male subfertility--a review. 10 19

Endocrinological aspects of male infertility are reviewed, beginning with the physiological interrelationship between the testis and the hypothalamo-hypophysical unit. The failure of the pituitary to secrete follicle stimulating hormone (FSH) and luteinizing hormone (LH) results in disruption of testicular function and infertility. However, in men presenting with infertility, gonadotropin deficiency accounts for less than .5% of the causative factors. If deficiencies in FSH or LH are proved, a hypothalmic or pituitary lesion should be sought. Nevertheless, mreasurements of FSH, LH, and prolactin are useful tests in the management of male infertility. Of greatest importance is measurement of serum FSH, which provides a useful index of the state of the seminiferous epithelium when the concentration is related to sperm density: high concentration associated with severe oligospermia or azoospermia usually denotes untreatable infertility. Elevated LH and low testosterone levels have been found in about 30% of men with severe degrees of testicular damage and are indicative of interstitial cell failure. Prolactin measurements are mainly associated with impotency rather than infertility. Hormonal treatment of male infertility is often indicated. For example, replacement therapy for gonadotropin deficiency is successful. Androgen injections of testosterone esters will suppress spermatogenesis, so when treatment is stopped, sperm counts will rebound to concentrations greater than pretreatment levels. That endocrine factors can potentiate testicular damage is postulated based on the measurement of FSH as an indicator of seminifirous tubule disruption resulting in disruption of spermatogenesis.
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PMID:Endocrinology of male infertility. 38 66

The causes of male infertility generally fall into three categories: pretesticular, testicular and posttesticular causes. The pretesticular causes are extragonadal endocrine disorders, such as those originating in the pituitary or the adrenals, which have an adverse effect on spermatogenesis. The testicular causes of infertility are conditions in which the primary defects reside in the testes. The posttesticular causes of infertility consist mainly of obstructions of the ducts leading away from the testes. Testicular biopsy is an important method in the diagnosis and management of male infertility.
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PMID:[Results of testicular biopsy in azoospermia]. 43 92

Four of sixteen couples whose infertility was thought to be due to a male factor achieved a pregnancy without treatment. Pregnancy without therapy, despite compromised sperm counts or motilities, has been documented by a number of other authors. Despite this information many studies concerning the treatment of male infertility neglect to include control groups, and pregnancies which occur are credited solely to the therapy. Such claims of therapeutic success should be viewed with caution.
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PMID:Spontaneous cure of male infertility. 43 64

Absent scrotal ligament or the aligamentous testicle is a clinicopathologic entity which plays an important role in the genesis of male infertility. Twenty-four cases of aligamentous testicle, collected from 300 idiopathic infertile subjects, were studied. Clinical, endocrine, semen, and testicular biopsies were performed. The criteria of diagnosis of the aligamentous testicle are outlined and the role in infertility is discussed. Eighteen infertile patients with aligamentous testicle were treated by orchiopexy aiming to create an artificial scrotal ligament. The technique is described. The results were satisfactory. Failures were due to bad selection of patients.
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PMID:Aligamentous testicle. New clinicopathologic entity in genesis of male infertility and its treatment by orchiopexy. 44 22


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