Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0021345 (infectious mononucleosis)
 3,358 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The majority of peripheral blood mononuclear cells (PBMC) from acute-phase infectious mononucleosis (IM) patients express high levels of T10 (CD38) and HLA-DR surface antigens, which are markers characteristic of activated T cells. However, Tac antigen (p55) expression on these cells was not detectable by flow cytometric immunofluorescence, and only a low level of specific interleukin-2 (IL-2) binding was found by Scatchard analysis. These results suggest that IL-2 receptors (IL-2R) are lost or down-regulated on activated T cells in acute IM. Since a large proportion of T cells die during the first 24 h of in vitro culture in the absence of exogenous IL-2, the data implicate a physiological role for the observed low levels of IL-2R on T cells.
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PMID:Interleukin-2 receptors in infectious mononucleosis. 263 70

The in vivo expression of T-cell activation antigens defined by means of an OKT series of monoclonal antibodies and the anti-Tac antibody was evaluated in peripheral T lymphocytes obtained from patients with infectious mononucleosis and in cerebrospinal fluid (CSF) cells collected from individuals with mumps meningitis by the immunoperoxidase method. Although Tac antigen was definitely expressed on about 10% of CSF cells in mumps meningitis, Tac+ T cells could not be identified on any peripheral blood T cells in infectious mononucleosis, which expressed OKIa 1+, OKT10+, and OKT9+ determinants, as a probable sign of in vivo activation. The coexpression of Ia+ antigens on a T-cell functional subset might be important for their functional properties. Our kinetic study and cell cycle analysis of the expression of these activation antigens suggested that Tac antigen might be expressed at the early stage of the G1 phase of the cell cycle; OKT9+ antigen at the late stage of the G1; and Ia+ and OKT10+ determinants might be expressed at the S phase or later on in vitro, probably one after another.
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PMID:Kinetics of expression of T-cell "activation" antigens on in vivo- and in vitro-stimulated T cells. 609 81