Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0021345 (infectious mononucleosis)
 3,358 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The role of autoimmune mechanisms in idiopathic small fiber neuropathy (SFN) is not completely understood. Serum IgM binding to trisulfated disaccharide IdoA2S-GlcNS-6S (TS-HDS) and IgG to fibroblast growth factor receptor 3 were associated with sensory motor polyneuropathies and sensory neuronopathy among others. In this retrospective case review, we describe the clinical and laboratory findings of idiopathic SFN in a small cohort of pediatric patients. Eight children were diagnosed with SFN clinically and confirmed by reduced epidermal nerve fiber density. No involvement of large fibers was confirmed by clinical examination and electrophysiological tests. Possible triggering factors were infectious mononucleosis in 4 patients and human papilloma virus vaccination in 1 patient. Tilt table test was positive in 1 patient, and clinical autonomic dysfunctions were noted in 6 patients. Five patients had positive IgM against TS-HDS, 3 of whom had lower extremity predominant paresthesia. In conclusion, a high proportion of patients with idiopathic SFN in our cohort had a positive IgM TS-HDS antibody.
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PMID:Clinical and Laboratory Profiles of Idiopathic Small Fiber Neuropathy in Children: Case Series. 2882 87

A 20-year-old man developed bilateral forearm paresthesias after propping his elbows on the desk studying. He was diagnosed with ulnar neuropraxia and instructed to follow up with a neurologist. The symptoms continued and the patient was admitted for a formal workup of his neuritis. A Monospot test was positive. The patient was discharged with a diagnosis of infectious mononucleosis. A comment on his complete blood count, showing absolute lymphocytosis with atypical lymphocytes and rare blasts with flow cytometry recommended, was missed, possibly due to the fact that it was not highlighted red on the electronic medical record indicating an abnormal result. A month later, an outpatient diagnosis of B-lymphoblastic leukemia/lymphoma was made on flow cytometry. This case highlights cognitive errors in diagnosis, including premature closure and failing to 'see' key data, as well as vulnerabilities created by data display limitations of the electronic medical record.
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PMID:Blindsided by the Monospot test. 2954 32