Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0021345 (infectious mononucleosis)
 3,358 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One of mankind's most common illnesses is rhinitis, which almost regularly leads to involvement of the paranasal sinuses. Acute sinusitis is a consequence of a viral infection which, by damaging the mucosa, opens the door to bacterial superinfection. The aim of treatment is to cure the acute inflammation, re-establish normal drainage and ventilation, and prevent the development of "rhinosinugenic" complications. Acute otitis media is also preceded by viral damage to the mucosa. In children, acute otitis media is favored by the short, straight Eustachian tube, and often by adenoids. The therapeutic aim of antibiotic treatment and decongestive nose drops is to re-establish the draining function of the tube. Children who suffer from otitis media several times a year, need adenoidectomy. Acute tonsillitis, or quinsy, should be distinguished in particular from infectious mononucleosis. It is imperative to recognize a peritonsillar abscess, which requires more aggressive treatment.
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PMID:[Rhinitis, sore throate and otalgia... Benign common cold or dangerous infection?]. 1113 85

We report a case of acute Epstein-Barr virus (EBV) infection in which the clinical syndrome and pattern of F-18-2-fluoro-2-deoxy-D-glucose (FDG) uptake mimicked malignant lymphoma. A 53-yr-old man presented with 2 wk of high fevers, night sweats, sinus congestion and severe fatigue. The patient was treated for 1 wk with broad-spectrum antibiotics for acute sinusitis without any improvement. Persistence of fevers and presence of abnormal lymphadenopathy seen on the abdominal computed tomography (CT) were concerning lymphoma with B symptoms. FDG positron emission tomography (PET) showed avid FDG uptake in numerous abdominal/pelvic nodes, liver, spleen and bone marrow. These findings were highly suspicious for lymphoma. Patient underwent a pelvic lymph node biopsy which showed large granular lymphocytes that were predominantly T cells. Bone marrow biopsy showed diffuse infiltration with plasmocytoid cells that were not kappa lambda restricted. Additional diagnostic workup became available showing positive EBV IgM titers and negative IgG levels indicating acute infectious mononucleosis. Lymph node biopsy stained positively with EBV-encoded RNA. We concluded that patient's abnormal FDG PET was most likely secondary to acute EBV infection. After 2 months, follow-up FDG PET/CT showed marked improvement in lymphadenopathy and decreased hypermetabolic activity in the liver and spleen. Other than EBV, there are many other FDG-avid non-malignant conditions that may lead to false-positive PET scans. FDG accumulates in inflamed and infected lesions with increased glucose metabolism. This case underscores the importance of maintaining a broad differential and restricting use of PET scans for staging.
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PMID:FDG PET/CT findings in acute adult mononucleosis mimicking malignant lymphoma. 1846 55