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Query: UMLS:C0021311 (Infection)
 38,178 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Infection of several strains of laboratory mice with a virulent strain of Yersinia enterocolitica was followed by performing viable bacterial counts on homogenates of selected tissues at intervals after intragastric, aerogenic, or intravenous infection. It is observed that CD-1 mice are more susceptible to Y. enterocolitica infection than either the C(57)B1/6 or B6D2 strains. Development of an enteric infection is dose dependent; less than 5 x 10(7) organisms by mouth yields sporadic, low levels of systemic infection, with many of the animals showing no apparent infection. Increasing the challenge inoculum by a factor of 10 eliminates the variability among the animals, giving rise to an enteric infection in all of the mice that moves quickly to the mesenteric lymph node. The bacterial population in the lymph node multiplies rapidly, and the infection is disseminated to the spleen, liver, and lungs, ultimately killing most of the animals. Exposure to an aerogenic challenge of less than 1,000 organisms resulted in a fulminating pneumonitis with an invariably fatal outcome. Intravenous challenge with 500 organisms caused a rapidly fatal, systemic infection. The growth of the bacteria in the intravenously infected mouse depends upon the temperature at which the challenge inoculum had been grown in vitro. At temperatures below 26 C, the bacteria are cleared from the blood at a slower rate and are more resistant to intracellular killing, as compared to organisms grown at 37 C. This effect results in the inoculum increasing to greater numbers in the tissues in a shorter period of time.
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PMID:Experimental Yersinia enterocolitica infection in mice: kinetics of growth. 459 77

In vitro Evaluation of BRL 17421 (Temocillin), a New Penicillin. The in vitro antibacterial activity of BRL 17421 (temocillin), a new penicillin, was determined in quantitative serial broth dilution tests and was compared to that of mezlocillin, piperacillin, cefazolin and cefotaxime against 751 clinical isolates of the Enterobacteriaceae family. In addition, the sensitivity of 211 mezlocillin-resistant gram-negative rods to BRL 17421 was also determined. Temocillin exhibited a high level of antibacterial activity against various bacterial species of the Enterobacteriaceae family, including isolates resistant to mezlocillin. The 90% MICs against Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Enterobacter cloacae, Salmonella spp., Yersinia spp. and indole-negative and indole-positive Proteus strains ranged from 0.5 mg/l to 16 mg/l. Concentrations of 16 mg/l were required to inhibit 80% of the Serratia marcescens strains; some isolates were resistant. No significant difference between MIC and MBC values was observed.
Infection
PMID:[Microbiological studies with the new penicillin BRL 17421 (temocillin)]. 630 7

An unusual case of Yersinia pseudotuberculosis septicemia is reported. Diabetes mellitus was the sole underlying disease; liver enzyme elevations were only transitory. The strain did not show motility until after 50 days at room temperature; it showed temperature and media-dependent fermentation of arabinose, melibiose and rhamnose.
Infection
PMID:Yersinia pseudotuberculosis: unusual features of a case. 635 10

The relationship between invasiveness and calcium dependency was examined in various strains of Yersinia enterocolitica and Y. pseudotuberculosis by using established cell lines. Infection with calcium-dependent bacteria resulted in the formation of microvilli and the adherence of bacteria on the cell surface, and the adherent bacteria were ingested 1.5 hr after infection. Morphological changes in the cells became visible 2 to 3 hr after infection, and intracellular multiplication of the ingested bacteria was noted. When the cells were incubated with bacteria at 37 C for 1.5 hr and then at 25 C, however, the morphological changes in the infected cells were not observed. No isogenic strains that had lost calcium dependency for growth at 37 C were able to elicit the morphological changes in the cells, though they possessed the ability to adhere to and penetrate the cells. The antigen(s) supposedly related to cytotoxicity of the calcium-dependent Yersinia was sought by using antibodies prepared against calcium-dependent bacteria and then absorbed with calcium-independent bacteria and with calcium-independent bacterial cytosol. Double diffusion tests between the antisera and bacterial cytosol extracts revealed the presence of an antigen which was a cytoplasmic substance common to all calcium-dependent but not calcium-independent strains of Y. enterocolitica and Y. pseudotuberculosis.
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PMID:Cytotoxicity and calcium-dependent antigen of Yersinia. 672 13

111Indium-leucocyte scanning demonstrated enteritis in a patient with acute arthritis and diarrhoea when contrast radiology was normal. Infection with Yersinia entercolitica was proved serologically. Leucocyte scanning may be useful in the screening for inflammatory bowel disease in patients with seronegative arthritis.
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PMID:Yersinia arthritis: demonstration of occult enteritis by 111indium leucocyte scanning. 674 9

Infections of the cardiovascular system, besides involving both natural and prosthetic heart valves, vascular grafts, and indwelling venous and arterial cannulas, may cause mycotic aneurysms. The latter frequently complicate endocarditis; however, they may occur as isolated phenomena. Enterobacteriaceae are uncommon etiologic agents in vascular infections; however, a patient is reported who presented initially with a bacteremia due to Yersinia enterocolitica biogroup 4 and despite antimicrobial therapy developed a mycotic aneurysm of the left internal carotid artery. Clinical manifestations, pathogenesis, and treatment of yersiniosis are reviewed.
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PMID:Mycotic aneurysm due to Yersinia enterocolitica. 689 58

In 352 patients who were hospitalized with symptoms of an acute appendicitis, Yersinia infection were determined in 18.2% of the cases by cultural and serological methods. Infections due to Y. enterocolitica (Y. e.) serovar 0:3 were approximately 6 times more frequent than those due to Y. e. serovar 0:9. Yersinia pseudotuberculosis (Y. pstbc.) could only be isolated in one patient from a mesenterial lymph node. In another case Yersinia serovar 0:6 could be isolated as well as Y. e. serovar 0:3. The majority of the infections were found in the age group 9-12 years. The incidence was highest in the summer months June-August.
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PMID:[Frequency and significance of infections due to Yersinia enterocolitica in "acute appendicitis" (author's transl)]. 703 57

Infection with Yersinia enterocolitica usually procedures gastrointestinal symptoms. We here report a severe case of panniculitis-like lesions caused by Yersinia enterocolitica where only mild gastrointestinal symptoms were noticed. Blood samples revealed high Yersinia enterocolitica serotype 3 titres, increased ESR, leucocytosis, and in addition Yersinia enterocolitica was cultured from the faeces. When panniculitis-like lesions are the only clinical manifestation yersiniosis should be considered as a possible cause.
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PMID:Panniculitis-like lesions in yersiniosis. 707 74

Signs of damage to the glomerular basement membrane appearing as haematuria and proteinuria have been observed in 16 cases of proven acute yersiniosis. The infecting agent was Yersinia enterocolitica serotype O:3 in all. In a few cases a transient deterioration of the renal function was observed. The renal symptoms were not related to the acute febrile state, but seemed to appear about 14 days after the onset of yersiniosis and to be reversible in the observation period. Infection with other microorganisms known as nephritogenic was not found in spite of attempts to do so. Kidney biopsy was performed in one case and immunofluorescence microscopy showed deposits of immunoreactants. Based on these observations we suggest that acute glomerulonephritis can be included in the spectrum of complications of infection with Yersinia enterocolitica serotype O:3. The frequency of complicating glomerulonephritis in yersiniosis could not be estimated from this study.
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PMID:Glomerulonephritis in infections with Yersinia enterocolitica O-serotype 3. I. Evidence for glomerular involvement in acute cases of yersiniosis. 721 94

Infections linked in time and space with Yersinia enterocolitica (serovar 0 : 9, biotype 2, lysotype X3) were observed in 6 cases within one university hospital. After a hospital epidemic in Finland in 1973 (involving 7 persons) this is the 2nd such observation. The spread was demonstrated in two areas. The probable source of infection of one patient group (n = 3) was a 48-year-old dialysis patient admitted with a febrile condition without enteritic symptoms. Pathogens could be demonstrated in his faeces by direct culture, in two contact persons cultivation was possible only with cold enrichment. Blood cultures of the first patient were negative. At about the same time 3 further infections with Yersinia enterocolitica of the same characteristics were observed in hospital personnel from different units. Frequent exchange of staff and patients among affected wards increases likelihood of cross-infection. A dialysis nurse with Yersinia arthritis was the possible link between patients and personnel. Transference of infection from one person to another can be assumed in the above cases.
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PMID:[Spread of Yersinia enterocolitica infection within a hospital (author's transl)]. 735 85


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