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Query: UMLS:C0021051 (immunodeficiency)
 71,517 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although a substantial number of studies have been conducted to evaluate the impact of various human immunodeficiency virus (HIV) prevention programs, most of them have focused on civilian populations. There is a clear need to develop and evaluate sexually transmitted diseases (STD)/HIV prevention programs designed specifically for U.S. military populations. The objective of the present study was to determine whether a behavioral intervention known as the STD/HIV Intervention Program (SHIP) would have a sustained positive impact on the behavior of a sample of Marines. A 1-year follow-up telephone interview was administered to (1) Marines who participated in the SHIP course (intervention group), and (2) a quasi-control group of Marines who were not exposed to the SHIP course. The intervention and control groups differed significantly in the percentage of the time they had used condoms during the past year. The intervention participants reported using condoms a greater percentage of the time than the nonparticipants.
Mil Med 2001 Nov
PMID:One-year follow-up evaluation of the sexually transmitted diseases/human immunodeficiency virus intervention program in a marine corps sample. 1172 29

Mice homozygous for the autosomal recessive "wasted" mutation (wst/wst) have abnormalities in T lymphocytes and in the anterior motor neuron cells of the spinal cord, leading to sensitivity to low doses of ionizing radiation, hind limb paralysis, and immunodeficiency. This defect results in a failure to gain weight by 20 days of age and death by 28 days. The wasted mutation (previously mapped to mouse chromosome 2) is shown to be a 3-bp deletion in a T cell-specific (and perhaps motor-neuron-specific) regulatory region (promoter) of the proliferating cell nuclear antigen (PCNA) gene on mouse chromosome 2. A regulatory element is also shown to be important in PCNA expression in T lymphocytes and motor neuron cells affected by the 3-bp deletions in the PCNA promoter. The model is as follows. Absence of PCNA expression in the thymuses (and motor neurons) of wasted mice causes cellular apoptosis. This absence of expression is mediated by a positive transfactor that can bind to the wild-type but not to the wasted mutant PCNA promoter. The bound protein induces late expression of PCNA in T lymphocytes and prevents onset of radiation sensitivity in the cells.
Mil Med 2002 Feb
PMID:Sensitivity to low-level radiation in radiosensitive "wasted" mice. 1187 11

Research evaluating human immunodeficiency virus (HIV) behavioral interventions among U.S. military personnel has been lacking. In this study, a behavioral intervention to prevent HIV and sexually transmitted diseases (STDs) was implemented in a sample of Marine security guards. Participants were assessed before and after a three-session intervention on a measure of STDs/HIV knowledge and a number of psychosocial scales. The results indicated that STDs/HIV knowledge was significantly greater after the intervention. Significant pre-test vs. post-test differences were also found on the Social Norms, Behavioral Intentions, Attitudes toward Condoms, and Self-Efficacy/Impulse Control scales. On Social Norms and Behavioral Intentions, the differences were as expected: subjects perceived greater social norms supporting condom use and had stronger intentions to practice safe sex after the intervention than they had before. On Attitudes toward Condoms and Self-Efficacy/Impulse Control, the differences were not in the expected direction. Psychosocial factors associated with self-reported condom use were also identified.
Mil Med 2002 Feb
PMID:A behavioral intervention to prevent sexually transmitted diseases/human immunodeficiency virus in a Marine Corps sample. 1187 38

Little is known about the comparative effectiveness of human immunodeficiency virus prevention interventions that differ in duration but contain similar content. The objective of this study was to evaluate and compare the effectiveness of two versions (6 hours vs. 3 hours) of a behavioral intervention called the STD/HIV Intervention Program (SHIP) in a sample of Marines. Marines were exposed to either a 6-hour or a 3-hour version of SHIP. Comparisons of pre-test and post-test knowledge, attitude, and behavioral intention scores revealed similar results for both versions. For both versions of the intervention, scores on sexually transmitted diseases/human immunodeficiency virus knowledge were significantly higher after the intervention. Both the 6-hour and the 3-hour versions of SHIP also led to significant increases on scales measuring social norms and behavioral intentions. The two versions of SHIP appeared to be of comparable effectiveness for producing short-term changes in knowledge, attitudes, and behavioral intentions.
Mil Med 2002 Mar
PMID:Effectiveness of two versions of a sexually transmitted diseases/human immunodeficiency virus prevention program. 1190 77

This study examined changes in sexual behavior among Thai army conscripts from 1992 to 1998 in association with human immunodeficiency virus (HIV) seroprevalence. The sexual behavior survey was started in 1992 during the epidemic of HIV infection in Thailand, when sexual transmission was the most common route and young men were at high risk, and it has continued yearly since 1995. The self-reported questionnaires were administered to randomly selected conscripts (N = 294 in 1992, N > 4,000 in 1995-1998), and trends in sexual behaviors were studied. The results showed that risky sexual behaviors generally decreased in relation to the decline in HIV seroprevalence, but the conscripts still engage in risky sexual behaviors. Appropriate interventions should be implemented to change these behaviors. The periodic sexual behavior surveys will be useful in evaluating program outcomes and planning for future interventions.
Mil Med 2002 Apr
PMID:Sexual behaviors and human immunodeficiency virus infection among Thai army conscripts between 1992 and 1998. 1197 75

Catania province, Sicily, is an important foci for human visceral leishmaniasis. Current data indicate an annual average incidence of 10 registered cases per year during the past 3 years. Of registered cases, more than 20% were among individuals who were also human immunodeficiency virus positive. Since the 1930s, no vector studies have been performed in this area. From May through November 1997, sandflies were collected using Centers for Disease Control and Prevention light traps and a sticky-trap method. Collecting sites were chosen throughout Catania and represent the diversity of the region (rural, semiurban, and sylvan areas). Meteorological data were recorded during the survey. The most common species, of 2,775 specimens collected and identified, was Phlebotomus perniciosus (23.3%), followed by Phlebotomus perfiliewi (1.1%) and Phlebotomus neglectus (0.2%); one specimen of Phlebotomus papatasi was found at the site. Sergentomyia minuta (72.4%) was found at all sampling sites. None of 137 sandfly females, which were caught at the Brucoli and Sigonella stations and dissected for natural transmission study, contained parasites.
Mil Med 2002 Sep
PMID:Leishmaniasis in Sicily (Italy): an investigation of the distribution and prevalence of phlebotomine sandflies in Catania Province. 1236 59

Access to experienced providers is an important part of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome management, especially for patients who are just starting a new or complicated treatment regimen. To date, few studies have addressed the potential barrier of geographic distance in access to care in the HIV/acquired immunodeficiency syndrome population. We performed a retrospective study examining the effects of driving distance from a major Naval medical treatment facility on clinical outcomes for Department of Defense beneficiaries recently diagnosed with HIV. The outcomes studied include attainment of undetectable HIV-1 RNA levels and change in mean CD4+ T cell counts 6 months after initiation of management in 132 Department of Defense beneficiaries. We found no significant associations between distance from a major medical treatment facility and these clinical outcomes through 6 months of follow-up. These findings suggest that stationing HIV-infected military personnel far from major Medical Treatment Facility does not interfere with initial successful HIV management.
Mil Med 2003 Feb
PMID:The effect of driving distance from medical treatment facility and short-term management outcomes in Department of Defense beneficiaries newly diagnosed with human immunodeficiency virus. 1263 34

Since 1985, the U.S. Armed Forces have conducted routine testing of personnel for antibodies to human immunodeficiency virus type 1. Sera that remain after testing are archived in the Department of Defense serum repository for potential uses in medical surveillance, clinical, and research activities. The goal of this study was to document the timing and completeness of routine human immunodeficiency virus type 1 testing among active duty military personnel and to identify factors associated with more recent testing. Demographic characteristics for active duty personnel were obtained from the Defense Medical Surveillance System. Of all individuals on active duty on August 31, 2001 (N = 1,370,367), 98.6% had been tested. Older personnel, those with postgraduate degrees, and married personnel had the longest time intervals since their most recent tests. The results of this analysis may inform the planning and conduct of human immunodeficiency virus type 1 prevention programs as well as deployment-related or other surveillance activities.
Mil Med 2003 Feb
PMID:Timing and completeness of routine testing for antibodies to human immunodeficiency virus type 1 among active duty members of the U.S. Armed Forces. 1263 47

We have identified and prioritized a series of objectives that warrant inclusion in the continuum of military medical education. Although participants in the 16th Conference on Military Medicine also discussed whether each objective should be taught at the medical student, resident, or staff physician level, to a large extent this distinction is not helpful, since many, if not most, of these topic areas would likely require incorporation at each of these three levels to achieve the desired level of competence in staff physicians. Incorporation of new curricular elements poses a significant challenge, since it is already difficult to fit the existing curriculum into the available time. It is not reasonable to consider increasing the number of lecture hours. Therefore, it is probable that some elements of the existing curriculum will need to be pared down or eliminated to incorporate new material. In the past, when new material has been added to the existing curriculum, such as when the pathogenesis of human immunodeficiency virus was added, it has generally been done at the individual teacher or at most departmental level. Although this approach has the advantage of having a subject matter expert decide how best to insert new material within the fabric of the existing curriculum, there are a couple of problems with widespread use of this approach. First, some of these new objectives may not fit clearly within an existing course curriculum or department's educational mission. Second, such an approach may not provide the degree of coordination that is necessary to ensure that a new curricular item is adequately covered in all respects, and it may result in unnecessary overlap in instruction when different professors incorporate similar elements. Therefore, the prioritization of newer curricular items, as has been done during this conference, may serve as a useful guide in this process. However, a corresponding effort is needed to identify and prioritize existing curricular components. Decisions need to be made regarding what, within the existing curriculum, should be cut out or reduced to make room for some or all of these new objectives. Finally, a decision needs to be made regarding which of these identified objectives should be inserted and when and within which courses they should be taught. These are important decisions that should not be left to the whims of chance. As the responsible recipients of Uniformed Services University and Health Professions Scholarship Program medical school graduates, the services' Surgeons General need to take an active role in helping to make these decisions. The outcome of these decisions will have a direct impact on the capabilities that these future junior medical officers will bring to the patients they will care for and to the line commanders that they will support.
Mil Med 2003 Sep
PMID:Military unique curriculum: identifying and prioritizing content. 1452 92

Human immunodeficiency virus (HIV) infection has become a pandemic concern for many nations. When this disease first presented itself in a global manner in the early 1980s, it was accompanied by fear, denial, misunderstanding, social stigma, and a paucity of available support services. The U.S. Army was becoming increasingly aware of the potential impact HIV could have on the active forces. A tragic event involving the suicide of a young HIV-infected soldier resulted in the development of a comprehensive medical/psychosocial assessment and treatment program for HIV-infected service members and their families at the Walter Reed Army Medical Center. Social work services played an integral role in the development of this program as this profession has done historically in meeting other emerging needs of the military. Special attention is given to the unique psychosocial issues and needs of the HIV-infected service member and the comprehensive and compassionate response of the military medical team with its significant social work contribution.
Mil Med 2003 Sep
PMID:Human immunodeficiency virus social work program at the Walter Reed Army Medical Center: a historical perspective. 1452 41


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