Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0021051 (immunodeficiency)
 71,517 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The paper provides the results of examining about 3,000 industrial workers exposed to various xenobiotics. Various phases of immune responses were noted in 40-60% of persons with nonspecific chronic pulmonary, gastrointestinal, gynecological diseases at remission. 10-20% of the industrial workers under study were diagnosed as having secondary immunodeficiency whose criteria were the presence of one of clinical syndromes, a sharply significant reduction in immunoglobulins, normal levels of circulating immune complexes and normal values of the lymphocytic enzymes alpha-glycerophosphate dehydrogenase, succinate dehydrogenase, lactate dehydrogenase. The stimulation of the immune system in clinically healthy individuals who have a service length of 3 year or more should be regarded as development of an immune response to a xenobiotic or its metabolites.
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PMID:[Immunological mechanisms of the formation of ecologically-induced pathology]. 752 43

To investigate the effects of HIV infection on mitochondrial DNA (mtDNA) content and other mitochondrial parameters, we used peripheral blood mononuclear cells (PBMCs) from 25 asymptomatic antiretroviral-naive human immunodeficiency virus (HIV)-infected patients and from 25 healthy control subjects. HIV-infected patients had significant decreases in mtDNA content (decrease, 23%; P<.05) and in the activities of mitochondrial respiratory chain (MRC) complex II (decrease, 41%; P<.001), MRC complex III (decrease, 38%; P<.001), MRC complex IV (decrease, 19%; P=.001), and glycerol-3-phosphate dehydrogenase (decrease, 22%; P<.001), along with increased lipid peroxidation of PBMC membranes (P=.007). Therefore, HIV infection is associated not only with mtDNA depletion, but also with extensive MRC disturbances and increased oxidative damage.
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PMID:Mitochondrial effects of HIV infection on the peripheral blood mononuclear cells of HIV-infected patients who were never treated with antiretrovirals. 1573 31