Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0021051 (immunodeficiency)
 71,517 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The patient was a 31 year old male complaining discomfort in the epigastrium. Endoscopy of the upper gastrointestinal tract indicated multiple gastric ulcers. Biopsy specimen taken from the ulcerous region indicated giant cells accompanying intranuclear inclusion bodies in the gastric mucosa. Since the patient tested positive to cytomegalovirus (CMV)-IgM antibody, he was assumed to have gastric ulcers caused by CMV infection. However, the patient was cured without the administration of antiviral agent because no definite immunodeficiency status was observed. The result of present study indicated that endoscopic biopsy is useful for diagnosing gastrointestinal lesion attributable to CMW infection.
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PMID:A multiple gastric ulcer case caused by cytomegalovirus infection. 910 Apr 66

Questionnaires administered to 387 young people (mean age, 18.8 years) from nine randomly selected rural and urban secondary schools in Uganda's Kabarole District confirmed the effectiveness of acquired immunodeficiency syndrome (AIDS) health education efforts in this population. 84.7% of students indicated they had received school-based AIDS education and the overall knowledge level was high, exemplified by the fact that 83% were aware that individuals infected with human immunodeficiency virus (HIV) can appear healthy. 37.1% of students perceived themselves as at risk of HIV infection in the next five years. On the other hand, 80.6% expressed the intent to use condoms and 73.1% felt able to acquire them. 73.1% opposed discrimination against persons with AIDS. Regression analysis indicated that about 25% of the variance in perceived condom use self-efficacy was accounted for by perceptions as to condom effectiveness. 49% of the variance in female's intention to use condoms was explained by self-efficacy, perceived condom effectiveness, perceived susceptibility to HIV, perceptions of AIDS severity, condom acquisition self-efficacy. and confidence in terms of partner discussions about sexual histories. In males, however, these six variables explained only 25% of the variance, suggesting that there are unidentified determinants of condom use. These findings did indicate a need for school-based skills development, possibly through role play, to reduce young people's discomfort with condom purchasing and discussions of sexual histories.
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PMID:HIV-preventive cognitions amongst secondary school students in Uganda. 1016 Feb 27

Perianal infections caused by herpes simplex virus are common in immunocompromised patients. The cutaneous presentation in these patients is often atypical, overlaps with the clinical features of other diseases, poses a difficulty in diagnosis, and responds poorly to treatment. An immunocompromised patient with chronic lymphocytic leukemia, treated with oral corticosteroids, presented with chronic perianal ulcerations. This patient was referred for evaluation and treatment of "recalcitrant" pyoderma gangrenosum. Prompt diagnosis was possible when the clinical features were recognized and appropriate biopsy and cultures were obtained. We describe an atypical presentation of herpes simplex virus associated with both an endogenous and exogenous induced immunodeficiency, and stress the importance of routinely performing cultures on all perianal ulcerations and anal fissures to avoid the misdiagnosis, inappropriate treatment, and prolonged discomfort of these afflicted patients.
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PMID:Atypical presentation of herpes simplex virus in a patient with chronic lymphocytic leukemia. 1046 7

A sample of approximately 200 undergraduate students beginning their nursing education responded to questionnaire items concerning experience and levels of comfort working with diverse client groups. Students reported little discomfort with racial/ethnic groups, but reported they would have considerable difficulty working with lesbian, gay, or bisexual clients, and patients with human immunodeficiency virus. Their reasons for discomfort were examined.
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PMID:Experiences and comfort with culturally diverse groups in undergraduate pre-nursing students. 1078 60

Retaining African-American women who are human immunodeficiency virus (HIV) positive in longitudinal research is crucial to improving prevention and treatment in this population. Interviews with 22 African-American HIV-positive women conducted at the end of a 2-year study indicated that over the course of the study, reports of discomfort with participation gave way to reports of appreciating the benefits of participation. Women commented on the importance of their relationships with researchers, in which they received benefits and provided a service to the researchers. We postulate that developing reciprocity between research teams and participants may be helpful in retaining African-American women in research.
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PMID:Reciprocity and retaining African-American women with HIV in research. 1184 Apr 8

We determined the immunogenicity and safety of reimmunization with the 23-valent polysaccharide pneumococcal vaccine in patients infected with human immunodeficiency virus type 1 (HIV-1). Patients immunized >5 years earlier (initially within 1 year of HIV-1 seroconversion) were randomized to receive vaccine (n=57) or placebo (n=30). Persons with recent HIV-1 seroconversion (n=14) were immunized for the first time. Preimmunization levels of capsule-specific immunoglobulin G were similar in all groups. Reimmunized patients showed a significantly lower frequency and magnitude of antibody responses compared with persons with recent HIV-1 seroconversion. Reimmunized patients did not show adverse virologic or immunologic changes, but some reported local discomfort (15%) or fever (8%). Thus, the limited responses after reimmunization of HIV-1-infected patients with the current 23-valent vaccine mandates the need for a more effective reimmunization schedule, more immunogenic vaccines, or other behavioral and therapeutic interventions.
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PMID:Reimmunization with 23-valent pneumococcal vaccine for patients infected with human immunodeficiency virus type 1: clinical, immunologic, and virologic responses. 1185 Aug 63

Onychomycosis (fungal nail infection) is common and causes considerable discomfort and pain for many otherwise health patients. However, onychomycosis is especially prevalent in some patient groups seen regularly by community nurses (e.g. the elderly and people with diabetes, human immunodeficiency virus (HIV) infection or psoriasis). This article discusses the causes and types of onychomycosis, and examines in detail the various treatments available. Both the infection and its treatment can cause several clinical problems including drug interactions, difficulties with differential diagnosis and compromise of clinical outcomes. In particular, onychomycosis can undermine foot care in people with diabetes. The role of community nurses in treating and preventing onychomycosis is discussed.
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PMID:Fungal nail infections: far more than an aesthetic problem. 1204 99

The sociocultural environment in Indonesia's Batam Island has been disrupted by tourism, trade, prostitution, temporary marriages with foreign businessmen, and a general infusion of Western values. To facilitate the design of an effective sex education and reproductive health program, the Perspective Foundation of Indonesia conducted a reproductive health survey of 125 men and women from 11 island villages. Polygamy was defended as an alternative to sex with prostitutes, although younger men had more favorable attitudes toward sex outside of marriage. Contraception is viewed solely as a means of pregnancy prevention, and many women expressed discomfort with side effects. Younger men use condoms for protection with prostitutes, but not with their primary partners. Human immunodeficiency virus is viewed as a homosexual disease spread by touching. Views about sex roles are traditional, and men are considered as not masculine if they support their partner's needs. Finally, islanders believe that the male sexual drive is designed for procreation and pleasure, while the female sex drive is strictly for procreation. On the basis of these findings, researchers have decided to incorporate sex education within the broader context of health promotion and disease prevention.
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PMID:Researching cultural backgrounds to establish effective sexuality education programs. 1234 28

Uveitis is the inflammation of any or all parts of the vascular tunic of the eye; the vascular tunic includes the iris, the ciliary body, and choroid. A good knowledge base, up-to-date reference materials, and good instruments will improve the diagnosis of uveitis. Feline uveitis can be caused by numerous infectious agents in addition to neoplasia and less likely trauma. The infectious causes most commonly associated with feline uveitis include feline leukemia virus, feline immunodeficiency virus, feline infectious peritonitis, systemic fungal infections, toxoplasmosis, and bartonellosis. Neoplastic causes of uveitis can be primary or secondary. Iris melanoma is the most common primary uveal neoplasia and trauma-associated sarcoma is the second most common primary uveal neoplasia. Treatment for the clinical signs of anterior uveitis include topical steroidal or non-steroidal anti-inflammatory agents, parasympatholytic agents for ciliary spasm, to keep the pupil dilated, and to prevent posterior synechia. Posterior uveitis should be treated with systemic medications that will address the underlying cause. Enucleation of blind, painful eyes not responsive to medications is a means to alleviate the animal's discomfort and to further diagnose the underlying cause.
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PMID:Feline uveitis: diagnosis and treatment. 1594 26

Vaginal symptoms are common in the general population and are one of the most frequent reasons for patient visits to obstetrician-gynecologists. Vaginitis may have important consequences in terms of discomfort and pain, days lost from school or work, and sexual functioning and self image. Vaginitis is associated with sexually transmitted diseases and other infections of the female genital tract, including human immunodeficiency virus (HIV), as well as adverse reproductive outcomes in pregnant and nonpregnant women. Treatment usually is directed to the specific cause of vaginal symptoms, which most commonly include bacterial vaginosis, vulvovaginal candidiasis, and trichomoniasis. The purpose of this document is to provide information about the diagnosis and treatment of vaginitis.
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PMID:ACOG Practice Bulletin. Clinical management guidelines for obstetrician-gynecologists, Number 72, May 2006: Vaginitis. 1664 32


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