Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0021051 (immunodeficiency)
 71,517 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seven cats with squamous cell carcinoma involving the mandible were treated by surgery and radiotherapy. Surgery consisted of hemimandibulectomy or combined rostral and hemimandibulectomy, gastrostomy tube placement, and submandibular lymph node excisional biopsy. Radiotherapy (orthovoltage or 60Co) commenced 2 weeks after surgery. Histologically, the tumor invaded surgical margins in 6 of 7 cats. Nerve infiltration was histologically identified in 2 cats. All cats had stage-3 disease with radiographic evidence of mandibular bone involvement. Age ranged between 8 and 16 years (median, 10 years). Hypercalcemia (2), feline immunodeficiency virus (2), and hyperthyroidism (1), were detected in cats prior to treatment. Survival after surgery was a median of 14 months (range = 3 to 36 months, mean = 15 months). Six cats were euthanatized because of recurrence of disease at 3, 7, 9, 16, 21, and 36 months. One cat was euthanatized at 14 months because of an unrelated disease. Complications of tongue lagging, drooling after meals, mandibular drift, maxillary ulceration, and alopecia of the jaw developed in a few cats. Radiation at the primary site and regional lymph nodes after surgery of curative intent extended survival in cats with mandibular squamous cell carcinoma.
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PMID:Treatment of mandibular squamous cell carcinoma in cats by use of mandibulectomy and radiotherapy: seven cases (1987-1989). 139 85

Five children with human immunodeficiency virus type-1 (HIV-1) infection, aged 4 to 13 years, manifested extrapyramidal dysfunction characterized by rigidity/stiffness, ambulation difficulties/shuffling gait, dysarthria/drooling/swallowing dysfunction, hypomimetic/inexpressive facies, and bradykinesia. Levodopa therapy caused an initial improvement in all symptoms, and the effect was sustained in most patients. Levodopa is a useful adjunctive therapy in HIV-1-infected children with extrapyramidal syndromes, by enhancing motor function and improving their quality of life.
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PMID:Levodopa therapy improves motor function in HIV-infected children with extrapyramidal syndromes. 896 Jul 52

A three-year old spayed female Domestic Shorthair was diagnosed with chronic plasmacytic stomatitis involving the mandibular gingiva caudal to the canine teeth. The cat presented with excessive drooling and bleeding from the gums. The definitive diagnosis was made on oral tissue samples obtained by biopsy and submitted for histopathology. The management included bilateral extraction of the mandibular and maxillary premolars and molars with closure of the defects utilizing a single mucosal flap in each quadrant. Preoperative laboratory evaluation and negative feline leukemia virus and/or feline immunodeficiency virus testing were performed. Following surgical removal of the teeth, the inflammation improved for eight months before returning. The cat now maintains comfort with parenteral injections of corticosteroid approximately every three to five months. Compounding pharmacists play a vital role in the treatment of felines due to their small size concerns with toxicity and sensitivity to certain medications and their reluctance to be dosed. Even in medical cases where a surgical procedure is the final resolution to an issue, compounded preparations are often required prior to surgery, during surgery, and post surgery for the purpose of eliminating pain and discomfort in the feline patient.
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PMID:A treatment of stomatitis and treatment in cats. 2396 34