Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0021051 (immunodeficiency)
 71,517 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recurrent bacterial meningitis is an uncommon but life-threatening condition. The aim of this study was to evaluate the demographic, clinical, microbiological, and radiological features of recurrent bacterial meningitis in children. Fourteen patients (10 male, 4 female) treated for recurrent bacterial meningitis were reviewed. The mean age of the patients was 87 months (range: 6 months to 13 years). There were 67 episodes of meningitis documented in these 14 patients. Six patients had developmental anatomical defects, five had traumatic anatomical defects and three had primary immune deficiency diseases as predisposing conditions. We suggest that, in a case of recurrent meningitis, a pediatrician should question and examine the patient carefully in search of a possible anatomical defect or immunodeficiency. Vaccination and surgical treatment of the anatomical defects may be important.
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PMID:Recurrent bacterial meningitis in children: our experience with 14 cases. 2104 78

Recurrent bacterial meningitis is not a common disease and makes physicians seek underlying predisposing factors which can result from anatomic anomalies or immunodeficiency. In this paper we present a boy with recurrent bacterial meningitis with the history of trauma and sensorineural hearing loss. Mondini dysplasia was demonstrated with computed homographic scans (CT-Scan) of temporal bones.
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PMID:Recurrent bacterial meningitis in a child with hearing impairment, mondini dysplasia: a case report. 2345 30

Recurrent bacterial meningitis is an uncommon disease of childhood. It occurs most often in children who have an underlying predisposing disorder that can result from anatomic fistula or immunodeficiency. Cochleovestibular dysplasia is a rare malformation of the inner ear that is often associated with translabyrinthine cerebrospinal fistula and then can cause recurrent bacterial meningitis. We report an unusual case of recurrent meningitis revealing cochleovestibular dysplasia in a 9-year-old child. The malformation was confirmed by imaging and the child had surgery. The outcome was favourable with no recurrence of meningitis during the 3 years after the operation.
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PMID:[A rare cause of recurrent meningitis in children: cochleovestibular dysplasia]. 2528 53

Recurrent bacterial meningitis is very rare phenomenon in paediatric age group. Finding the aetiology of recurrent meningitis often poses diagnostic challenge to clinicians. Among the several aetiologies, structural deficiencies at the base of skull, congenital or acquired, are readily correctable ones and hence it's imperative to find out the location of the gap in order to surgically repair it. We report the diagnostic dilemma faced while managing a 15-year-old boy with recurrent pneumococcal meningitis. Aetiology could only be found after exclusion of immunodeficiency and performing a series of imaging studies. CT cisternogram clinched the diagnosis and patient was cured successfully. A single imaging modality, be it CT/MRI scan, although proven to be better than others according to literature, might not be sufficient while finding the cause of recurrent bacterial meningitis in an immunocompetent host.
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PMID:Diagnostic Dilemma in a 15-Year-Old Boy with Recurrent Pneumococcal Meningitis. 2865 67