Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0021051 (immunodeficiency)
 71,517 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Inbred mice have proved to be a promising model for the evaluation of antigen-specific and antigen-nonspecific immunomodulating activity of purified staphylococcal toxoid in humans. This toxoid induces the formation of pronounced humoral response to homologous and heterologous infections in humans and mice. In animal experiments purified staphylococcal toxoid has shown its capacity for the correction of secondary immune deficiency of different origin; when introduced into humans having secondary immunodeficiency associated with bacterial infections of different etiology, the preparation reproduces this effect.
 ...
PMID:[An experimental validation of immunotherapy with purified staphylococcal anatoxin]. 805 83

Course of the disease and some indices of immunity were studied in 100 children with Sonne's and Flexner's dysentery. Parameters of immunity in 32 children (the 1st group) were normal. 68 patients (the 2-nd group) had secondary immune deficiency and leukopenia. Recovery of immunodeficient children in use of antibiotics and prodigiosan was slowed down by 5.2 days as compared to that of children without immunodeficiency. Antibiotics used in combination with lysozyme in patients of the 1st group resulted in restoration of immunological reactivity and recovery in usual terms.
 ...
PMID:[The characteristics of the antibiotic therapy of acute dysentery in an immunodeficiency body state in children with leukopenia]. 806

Our immune system protects us from various pathogens, autoimmune processes and malignancy. Primary immunodeficiency disorders are rare, however in contrast to the conventional perception, primary immunodeficiency diseases are more common than expected and may occur at any age. An insult to the immune system, primary or secondary, may lead to an increased incidence of infectious diseases, autoimmune diseases and malignancies. Primary care physicians, frequently encounter children and adults who suffer from recurrent infections, emphasizing the need for a structured approach for the evaluation of patients with suspected immunodeficiency. The growing knowledge of the fundamental mechanisms and function of the immune system together with recent developments in the field of clinical immunodeficiency enables us to use advanced diagnostic tools for the early diagnosis and treatment of these patients. In this review, we summarize the main aspects and updates of primary and secondary immune deficiency diseases, outline the "red flags" of immunodeficiency states and offer a stepwise workup approach for primary physicians and clinical immunology specialists. Some of the immunodeficiency "red flags" include recurrent infections, invasive infections, atypical pathogens, partial response to antibiotic treatment and frequent use of antibiotics, failure to thrive, chronic diarrhea and fungal infections, unexplained skin rash and a family history.
 ...
PMID:[HOW TO APPROACH A PATIENT WITH SUSPECTED IMMUNODEFICIENCY]. 2730 52