Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0021051 (immunodeficiency)
 71,517 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Viral infections of the central nervous system in infants and children are uncommon but potentially serious illnesses. Common causes have included the enteroviruses (particularly polioviruses and coxsackieviruses), herpes viruses (type 1 and type 2 herpes simplex, varicella, and cytomegalovirus), arboviruses, rubella, mumps, measles (including subacute sclerosing panencephalitis), and human immunodeficiency virus. Several of these viruses, such as cytomegalovirus, herpes simplex, and vertically transmitted human immunodeficiency virus, may cause congenital infections. Others are acquired later in childhood. In recent years, immunization programs have significantly reduced the occurrence of some of these diseases. A brief survey of the clinical and pathological manifestations of these illnesses will be discussed along with current incidence data.
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PMID:Selected pediatric viral infections. 942 48

Viral infections of the central nervous system often result in a spectrum of movement disorders, ranging from slowness and rigidity to hyperkinetic movements such as chorea, ballism, dystonia, and myoclonus. The basal ganglia are especially susceptible to some viruses, because of their intrinsic neurotropism, a predilection of opportunistic infections for the deep gray matter of the brain, and possibly the mounting of an autoimmune response against basal ganglia antigens. Viral encephalitides reviewed here include those caused by the human immunodeficiency virus, influenza A virus, the Flavivirus family (such as West Nile virus, Japanese encephalitis virus), and herpes simplex. Hyperkinetic movement disorders associated with prion diseases will also be discussed. The clinical features, etiology, pathogenesis, diagnosis, and treatment of the underlying infections and ensuing movement disorders will be reviewed.
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PMID:Hyperkinetic movement disorders associated with HIV and other viral infections. 2149 92