Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0021051 (immunodeficiency)
 71,517 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acute respiratory infections are the main cause of morbidity worldwide, and pneumonia represents one of the main causes of death in children younger than the age of 5 years in developing countries. Several risk factors for acquiring respiratory infections in developing countries, such as poverty, restricted family income, low parental education level, low birth weight, malnutrition, and lack of breastfeeding, have been described. Another important factor in recent years that has aggravated the problem of acute respiratory infections in developing countries is the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) pandemic. In developing countries, identifying the etiology is difficult and World Health Organization recommends making the diagnosis of pneumonia based on clinical parameters. The diagnosis and suitable treatment administered by primary healthcare workers, particularly in rural areas, is part of the strategy to prevent mortality. Finally, it is important that industrialized countries support the economic growth of the developing countries to improve their healthcare system and to ensure that performed research studies will give benefits to their populations.
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PMID:Respiratory tract infections in children in developing countries. 1582 39

Acute respiratory infections (ARI) are responsible for 1.9 million deaths annually, or 20% of the total worldwide under 5-year mortality rate. Developing countries carry the major burden of these deaths. In sub-Saharan Africa, human immunodeficiency virus type 1 (HIV-1) plays a significant role in this high mortality rate. The clinical and radiological features of ARI in HIV-infected and non-infected children are similar, with few exceptions. Epidemiological mapping of aetiological agents is essential to develop standard case management guidelines. The role of newer cytokines (e.g., procalcitonin) in establishing aetiology requires further evaluation. Implementation of antiretroviral therapy, chemoprophylaxis and vaccination programmes for HIV-infected children will have a favourable impact on the huge burden of ARI in developing countries. Governmental and nongovernmental organisations must provide the financial and human resources needed to overcome this enormous challenge to global lung health.
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PMID:The role of HIV infection in acute respiratory infections among children in sub-Saharan Africa. 1601 64