Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0021051 (immunodeficiency)
 71,517 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Gastrointestinal dysfunction is a serious problem in many children infected with human immunodeficiency virus (HIV), the etiology of which has not been clearly defined. Quantitative nucleic acid amplification was used to study the correlation between shedding of HIV nucleic acids and gastrointestinal symptoms in HIV-infected infants and children. Many with HIV infection and persistent diarrheal disease shed HIV nucleic acids in their feces, as did an HIV-infected patient without apparent diarrheal disease. HIV nucleic acids were not found in feces of non-HIV-infected individuals. Intestinal infection with HIV appears to be important in the pathophysiology of gastrointestinal dysfunction in infants and children with HIV infection. Furthermore, the fecal shedding of HIV may play a role in HIV transmission in environments prone to high levels of fecal-oral contamination.
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PMID:Persistent diarrhea and fecal shedding of retroviral nucleic acids in children infected with human immunodeficiency virus. 205 18

More than a million people in the United States are now infected with human immunodeficiency virus (HIV), and by 1991, the United States will record 270,000 cases of acquired immunodeficiency syndrome (AIDS). At present, there is no way to estimate the number of AIDS patients who will be living in 1991. Intestinal diseases exert considerable morbidity and mortality on AIDS patients and persons with AIDS-related complex. The elevated frequency of certain intestinal infectious diseases in homosexual male AIDS patients has been attributed to sexual practices, but food seems a probable vector for some proportion of the infections in all AIDS-affected groups. Intestinal infectious diseases and resulting systemic infections can be life-threatening to AIDS patients. The infections may serve as cofactors that hasten HIV disease progression to AIDS, but absolute proof of this hypothesis is lacking. The longer the HIV-infected person maintains good general health and avoids potentially lethal infectious diseases, the better are the chances that effective treatments will be developed and made available. Foodborne diseases are generally avoidable, and increased education of AIDS patients and their physicians as to their nature is the key to their prevention.
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PMID:Food counseling for persons infected with HIV: strategy for defensive living. 249 55

Intestinal infections represent a major health problem in homosexual men. The spectrum of potential pathogens includes classic sexually transmitted pathogens, enteric bacterial and protozoan pathogens, and a wide range of opportunistic infections seen in patients with human immunodeficiency virus (HIV) infections. Diagnosis and treatment of these infections must be comprehensive, including a full microbiologic evaluation, assessment of the immuno-competence of the patient, and repeat examination following completion of therapy.
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PMID:Sexually transmitted enteric and rectal infections in homosexual men. 333 85

Gastrointestinal involvement is reported in approximately 50% to 93% of patients with human immunodeficiency virus. It is frequently the result of coinfection with several microorganisms. Selective Leishmania intestinal involvement presents with atypical symptoms for visceral leishmaniasis, and may appear as a relapse or as the first manifestation of the disease. The authors present a patient with acquired immune deficiency syndrome who has a history of treated leishmaniasis and gastrointestinal infection by showed Mycobacterium avium intracellulare (MAI). After the new onset of abdominal pain, an intestinal biopsy showed the presence of both MAI and Leishmania in duodenum. Intestinal infection by Leishmania must be included in the differential diagnosis in patients with a previous history of leishmaniasis or travel to an endemic area.
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PMID:Simultaneous intestinal leishmaniasis and mycobacterial involvement in a patient with acquired immune deficiency syndrome. 980 64

Mycobacterium avium complex (MAC) colitis is a rare complication of immunosuppression in solid organ transplant (SOT) recipients. Here, we describe a case of disseminated MAC infection with colitis following renal transplantation. Despite common pathways of immunosuppression, SOT recipients and human immunodeficiency virus (HIV)-infected patients differ in their typical presentations of MAC infection. Intestinal infections have been more commonly reported in HIV-infected patients than in SOT recipients. The explanation for this difference may be related to HIV's targeted effects on the CD4+ T-cell reservoir in gut-associated lymphoid tissue.
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PMID:A rare case of disseminated Mycobacterium avium complex with colitis in a renal transplant recipient. 3029 42