Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0021051 (immunodeficiency)
 71,517 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied the perinatal transmission of hepatitis C virus (HCV) in 70 high risk mother/infant pairs. Seventy-six percent of the mothers (53 of 70) were coinfected with human immunodeficiency virus (HIV) and 79% (55 of 70) had a history of drug addiction. During the follow-up HCV RNA was detected in 14 of 70 (20%) infants: 12% (2 of 17) in infants born to HIV-negative mothers; and 23% (12 of 53) in infants to HIV-positive mothers. The rate of vertical transmission was significantly higher in vaginally delivered infants than in those delivered by cesarean section (32% vs. 6%; P < 0.05). All 56 uninfected infants lost passively acquired anti-HCV by age 9 +/- 4 months and only 2 of 56 infants (4%) had evidence of HIV infection. Four of 14 HCV RNA-positive infants (29%) had evidence of HIV coinfection. We observed 3 clinical patterns of HCV infection: a transient viremia in 2 infants; an acute pattern in 2 infants; and a chronic pattern in 10 infants. All 4 HIV-coinfected infants had chronic HCV infection. All infants with a chronic pattern, had increased alanine aminotransferase values for more than 6 months and 5 had a liver biopsy that showed signs of chronic persistent hepatitis. HCV perinatal transmission was more frequent in infants born to HIV-coinfected mothers than in infants born to HIV-noninfected women, particularly when delivered vaginally.
 ...
PMID:Perinatal transmission and manifestation of hepatitis C virus infection in a high risk population. 776 Nov 84

The immunity parameters were studied in 42 pregnant women, HBsAg carriers, both clinically healthy and suffering from chronic liver diseases. Sixty pregnant women without liver diseases or HBs-antigenemia made up the reference group. A marked T-cellular immunodeficiency was revealed in pregnant women with persistent HBs-antigenemia and chronic persistent hepatitis, in contrast to the clinically healthy women whose cellular immunity parameters were the same as in healthy pregnant women. Besides cellular immunodeficiency, the pregnant women with HBs-positive chronic persistent hepatitis presented with a marked imbalance of the humoral immunity parameters and hypersensitization to liver lipoprotein, this indicating manifest shifts in the immunity system. Spontaneous abortions occurred much more often in women with chronic persistent or active hepatitides than in the controls. The authors claim that screening of pregnant women for HBsAg is advisable for deciding on the policy of pregnancy management.
 ...
PMID:[Immunity indices in the diagnosis of persistent HBs-antigenemia in pregnant women]. 804 61


<< Previous 1 2