Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0021051 (immunodeficiency)
 71,517 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

As of December, 1998, worldwide, 33.4 million people have been infected with human immunodeficiency virus (HIV). A wide variety of ocular disorders is associated with HIV. HIV can affect all structures of the eye. A large number of micro-organisms including virus, bacteria, fungi and protozoa, cause ocular diseases in HIV-infected patients. Out of these, cytomegalovirus (CMV) retinitis is the most common. Ocular tuberculosis (TB), syphilitic retinal diseases and ocular toxoplasmosis are other serious eye problems in HIV patients, especially in the developing countries. HIV can also cause microvascular abnormalities producing cotton-wool spots. Neoplasms and drug-induced ocular disorders may be other problems. Ophthalmologists need to have wide range of information regarding HIV/AIDS for better diagnosis and management of their patients with ocular abnormalities. Further research, data collection, continuing education and the latest information on eye problems of AIDS patients are essential for Indian ophthalmologists.
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PMID:HIV/AIDS and ocular manifestations. 1064 79

Ocular tuberculosis is relatively rare; however, the most common ocular lesion during ocular tuberculosis is uveitis. The recrudescence of this disease is probably caused by human immunodeficiency virus or long-term corticotherapy. The authors report a of chronic unilateral tuberculosis-related uveitis complicated by panophthalmia with subconjunctival abcesess and scleral fistula. A histopathological study revealed a granulomatous inflammation with caseous material. An extensive work-up revealed no extraocular lesion. A systemic bactericidal treatement associated with topical steroids decreased the local inflammation with phthisis bulbi, and with no spread of the infection. The authors discuss the etiopathogenic, clinical, and therapeutic aspects of tuberculosis-related uveitis.
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PMID:[Tuberculous uveitis]. 1135 Dec 14

Ocular tuberculosis (OTB) in patients with human immunodeficiency virus (HIV) commonly presents as choroidal tubercles or granuloma. We report a rare presentation of OTB with hypopyon granulomatous uveitis in a patient with HIV on highly active antiretroviral therapy (HAART). Aqueous humor polymerase chain reaction (PCR) was positive for Mycobacterium tuberculosis (MTB). Antitubercular therapy (ATT) was initiated despite which it progressed to scleral abscess and panophthalmitis. Enucleation with ball implantation was done. Histopathology revealed caseating granuloma with numerous acid-fast bacilli (AFB) and real-time PCR showed increased copies of MTB genome. After a full course of ATT, he had stable ocular and systemic condition at final follow-up.
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PMID:Tubercular panophthalmitis in a patient with human immunodeficiency virus infection: Proven clinicopathologically and by molecular diagnostic tests. 3282 75