Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0021051 (immunodeficiency)
 71,517 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sentinel testing for human immunodeficiency virus (HIV) infection aims to monitor the HIV epidemic by testing subgroups of the population, and such testing has been carried out at the Murray Street Clinic in Perth, Western Australia since August 1989. This clinic is part of the State Health Department and is dedicated to the diagnosis, management and control of sexually transmitted diseases (STDs) in Western Australia. Sentinel testing at this clinic is both voluntary and confidential. In the first 6 months of testing at the clinic, 2351 new patients were seen and 3000 HIV antibody tests were performed. The refusal rate for participation was 8%. No patient tested as a sentinel test or because of multiple heterosexual partners was HIV antibody positive. The first 6 months of sentinel testing at the Murray Street Clinic does not indicate a silent HIV infection in the self-selected sexually active group of people using the facilities of the clinic.
Int J STD AIDS
PMID:Sentinel testing for the human immunodeficiency virus antibody at the Murray Street Clinic, Perth, Western Australia. 195 18

This study compared the distributions of known human immunodeficiency virus (HIV) and acute hepatitis B virus (HBV) infection among drug injectors in Glasgow over a 3.5 year period. Data were obtained from all relevant laboratory request forms submitted to Glasgow's 3 virology laboratories during the period 1 January 1986 to 30 June 1989. The overall prevalence of HIV among those tested was 3.7% (66/1786). There were 125 cases of acute HBV infection. The male:female ratios for HIV and acute HBV were 1:1 and 2:1, respectively. Thirty-four per cent of persons with HIV were aged under 21 years compared with 53% with acute HBV. Three out of 10 areas of the city accounted for 92% of HIV infection but only 66% of acute HBV infection. HIV infection was not detected among drug injectors in 4 areas of the city but at least 2 cases of acute HBV infection were recorded in all 10 areas. The geographical and age distribution of acute HBV infection in Glasgow suggests that the potential for future spread of HIV among drug injectors remains considerable.
Int J STD AIDS
PMID:Distribution of HIV and acute hepatitis B infection among drug injectors in Glasgow. 195 20

The prevalence of viral and bacterial sexually transmitted diseases were studied in 101 men attending a dermatovenereal outpatient clinic in Mogadishu. A control group of 103 healthy adult men were included for the serological part of the study. Serological markers of hepatitis B virus (HBV), human immunodeficiency virus (HIV), cytomegalovirus (CMV) and herpes simplex virus (HSV) were studied. All sera were tested for syphilis markers. HBV serum markers were detected in 84% of the men in the study group and 66% of the healthy controls (P less than 0.005). Hepatitis B virus carriers were detected more frequently in the study group than among the controls. Also, 96% of the men in both groups had CMV antibodies and all of them had antibodies to HSV. No sera were found to contain HIV antibodies. The TPHA-positivity was 10% and 3% in the study and control groups respectively, and 5% of the patients had syphilis IgM antibodies. Sexual contact with prostitutes was recorded in 54% and 48% respectively of patients and controls, and such contact was correlated with TPHA-positivity in the study group. Chlamydia trachomatis antigen was detected in urogenital specimens of 14% of the men in the study group and gonococcal culture was positive in 53% of those with urethral discharge.
Int J STD AIDS 1990 Mar
PMID:Sexually transmitted diseases in men in Mogadishu, Somalia. 196 90

Epstein-Barr virus is an important aetiological factor in certain HIV-related syndromes, with its opportunist expression related to the level of host immunodeficiency. In asymptomatic people co-infected with HIV, EBV activity is reflected by increased viral shedding and rises in anti-EBV titres; as immunodeficiency ensues EBV manifests as epithelial hyperproliferation in OHL, and later as B-cell lymphoma in AIDS. The suggested role of EBV as a co-factor in the progression of HIV infection and development of AIDS has not been established, although another herpesvirus, cytomegalovirus, might play such a role. Advances in our understanding of HIV regulation and its interaction with other latent (herpes) viruses should provide important molecular and pharmacological approaches to the clinical management of advanced HIV disease.
Int J STD AIDS 1990 Sep
PMID:Acquired immunodeficiency syndrome and Epstein-Barr virus. 196 85

A method is described for detection of nonoxynol in condoms, based on methanol-water extraction followed by reverse-phase high-performance liquid chromatography. Using this method, we found that approximately 50% of the nonionic surfactant lubricant nonoxynol migrated into elastomers (rubber latex), resulting in a concentration of nonoxynol insufficient to inhibit human immunodeficiency virus (HIV) (less than 0.05%). In order to minimize the risk of sexual transmission of HIV, and to ensure spermicidal effect and optimal rubber properties, the concentration of nonoxynol in condoms, therefore, should either be increased, or nonoxynol should be packed separately. Further studies are needed to clarify and determine the solubility and migration of nonoxynols into elastomers.
Int J STD AIDS 1990 Sep
PMID:Evaluation of the amount of nonoxynol available in condoms for the inhibition of HIV using a method based on HPLC. 196 70

Antibodies to human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) and to human T-cell leukemia virus (HTLV-1) were investigated by ELISA, Western blot and radioimmunoprecipitation (RIPA) assay in 318 sera (191 males and 127 females) obtained from syphilitic patients. The sera from 10% of the males and 3.1% of the females were positive for HIV-1. None of the sera contained antibodies to HIV-2. Antibodies to HTLV-1-2 were present in the sera of 7.1% of the males and 4.8% of the females who were seronegative for HIV. Five out of 24 (20.8%) HIV-1 positive subjects had antibodies to HTLV-1-2 as well. Sera from another group of 58 syphilitic patients (38 males and 20 females in the Anti-Venereal Disease Department), seronegative for HIV-1 and HIV-2, who denied both i.v. drug abuse and blood transfusion, were investigated in the same manner. None of the males had antibodies to HTLV-1-2, while 2 females (10%) were positive.
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PMID:Antibodies to HTLV-1-2, HIV-1 and HIV-2 in syphilitic patients. 197 26

Homosexual men are at high risk of anorectal human papillomavirus (HPV) infection, HPV-related anal cancer, and precancer, conditions known to increase with immunosuppression. The relationship between anal HPV infection, human immunodeficiency virus (HIV) infection, and immunosuppression was studied in homosexual men seen at a sexually transmitted disease clinic. History or presence of warts on rectal examination, and detection of anorectal HPV DNA were each significantly associated with HIV seropositivity after adjusting for age, previous sexual behavior, and cultural or serologic evidence of other sexually transmitted diseases, including those previously identified as risk factors for acquisition of HIV infection. Decreased mean levels of T4 lymphocytes were significantly associated with the detection of anal HPV DNA. Prospective studies are needed to determine incidences of anal HPV infection and cancer among HIV-seropositive and -seronegative mean and to determine the temporal relationship of these infections to one another.
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PMID:Anal human papillomavirus infection among human immunodeficiency virus-seropositive and -seronegative men. 197 95

As condylomata acuminata often persist in individuals infected with the human immunodeficiency virus (HIV), an immunohistological study of warts from infected men was undertaken to further knowledge about human papillomavirus persistence in this group. Using an indirect immunoperoxidase method and a panel of monoclonal antibodies, the phenotypes of cells were studied in cryostat sections of perianal or anal warts removed from 14 HIV-infected men (10 homosexual and 4 heterosexual) and from 16 non-infected men (10 homosexual and 6 heterosexual). Although the median numbers of CD1+, CD3+ and CD4+ cells per unit area were similar in each group of individuals, the number of CD8+ cells was significantly higher in HIV-infected homosexual men when compared with non-infected individuals and HIV-infected heterosexual men. The median CD4+ cell count in the peripheral blood was significantly higher in HIV-infected heterosexual men than in HIV-infected homosexual men (P less than 0.05). These findings may reflect differences in duration of HIV infection between the two groups. There was no significant difference in the proportion of cells expressing interleukin-2 receptors between HIV-infected and non-infected individuals. Natural killer (CD16+) cells were not identified in any of the condylomata.
Int J STD AIDS 1990 Jan
PMID:Immunological study of condylomata acuminata in men infected with the human immunodeficiency virus. 198 71

A procedure to diagnose the infections by the human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) was proposed. The specimens were first screened by a mixed enzyme immunoassay (EIA) for the presence of antibodies to HIV-1 as well as to HIV-2. Those screened positive were thereafter confirmed and differentiated their antibody reactivities toward the antigens of HIV-1 and HIV-2 by Western blot (WB). This procedure was found to be one hundred percent accurate to diagnose 66 coded specimens with well defined seroreactivities to HIV-1 from Centers for Disease Control (CDC). While its accuracy in HIV-2 antibody testing could not be evaluated in the present study owing to the lack of HIV-2 standard reference specimens. With this procedure, six out of each of two groups of 176 foreigners and 719 individuals who visited the Taipei Municipal Venereal Disease Control Institute (TMVDCI) were screened repeatedly reactive by the mixed EIA. By WB only four of the first six and two of the second six were confirmed HIV-1 positive. Their antibody reactivities toward HIV-2 antigens were either absent or significantly much lower than those toward HIV-1 antigens. Furthermore, none reacted to the env proteins gp160 and gp120 of HIV-2. We therefore concluded that out of the 895 test individuals, only six were confirmed infected with HIV-1. There were neither HIV-2 infections nor dual infections. The similar pathogenicity and trans mission of HIV-2 as of HIV-1 justify an equal appreciation for HIV-2 testing. The present study indicated that a procedure starting with a mixed EIA aimed to diagnose HIV-1 as well as HIV-2 did not have any adverse effects on HIV-1 testing.
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PMID:Application of a procedure starting with an HIV-I/HIV-2 mixed EIA. 198 37

Saliva and blood samples were tested for human immunodeficiency virus-1 (HIV-1) antibodies in two high-risk populations in Kinshasa, Zaire. In a seroprevalence study of 458 sexually transmitted disease (STD) clinic attendees, 142 of 145 seropositive individuals had enzyme-linked immunosorbent assay (ELISA)-positive saliva samples (97.9% sensitivity). All saliva samples from seronegative patients were ELISA-negative (100% specificity). Of the 142 ELISA-positive saliva specimens, 137 were also Western blot-positive (94.5% sensitivity). In a subsequent seroincidence study of 315 initially seronegative female prostitutes followed during 183 woman-years of observation, 9 of 14 women who seroconverted (7.7% seroincidence) had ELISA-positive saliva samples at the time seroconversion was detected. Only three of these saliva specimens could be confirmed by Western blot. Although salivary testing for HIV-1 antibodies using conventional assays was not sensitive in detecting recent seroconversions, screening of salivary samples for HIV-1 antibody provides a convenient alternative method for conducting seroprevalence surveys in populations in whom venipuncture is not possible or convenient.
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PMID:Detection of salivary HIV-1-specific IgG antibodies in high-risk populations in Zaire. 198 55


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