Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0021051 (immunodeficiency)
 71,517 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report five cases of psychosis in patients with antibody to human immunodeficiency virus. All patients was man and intravenous drug abuser. The age range was 22 from 31 years with a mean of 25 years. In all cases acute schizophrenia was the first clinical picture of the HIV. Four patients had opportunistic infections and AIDS-Dementia Complex months later. If there is a genuine biological association between HIV carriage and schizophrenia illness, then HIV infection should be considered in the differential diagnosis of such an illness.
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PMID:[HIV and schizophrenia]. 210 15

Chronic mental patients may constitute a previously unrecognized high-risk group for the spread of the human immunodeficiency virus. This paper briefly reviews the literature on sexual awareness, sexuality, substance abuse, and schizophrenia, and addresses the problems of implementing sex education programs for chronic mental patients. Although problematic, such preventive programs are urgently needed.
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PMID:Chronic schizophrenia: a risk factor for HIV? 228 31

Numerous immunologic abnormalities have been reported in patients with schizophrenia, suggesting that this disorder may in some cases represent a viral or immunologic disorder of the brain. To further examine this question, evidence for intrathecal production of immunoglobulin (IgG) and immunoglobulin oligoclonal bands (OCB) was sought in patients with acute or early schizophrenia. Using high resolution zone electrophoresis and immunofixation, there was no evidence for intrathecal IgG generation in 5 of 5 patients tested. One of 9 patients had OCBs in CSF. This man, although he had a typical history of schizophrenia, tested positive for human immunodeficiency virus antibody in serum.
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PMID:Oligoclonal bands in acute schizophrenia: a negative search. 234 51

The evidence that schizophrenia may involve infection by a virus (or viruses) has been indirect. The recent discovery, however, of the human retroviruses--human T-cell lymphoma-leukemia virus-I, and II (HTLV-I, -II) and human immunodeficiency virus (HIV)--now also known to affect the central nervous system (CNS), together with the development of new techniques in retrovirology, have made it possible to investigate more directly the role of this class of viruses as an etiology of schizophrenia. In our first effort to screen for the presence of a T-cell lymphotropic virus in schizophrenia, short-term tissue cultures of peripheral lymphocytes from 17 chronic schizophrenic patients and 10 normal controls were established. The cells were cultured in the presence of T-cell growth factor (TCGF, IL-2), and the culture supernatants were tested for the presence of the retroviral enzyme reverse transcriptase. No T-cell-associated reverse transcriptase activity was detected in cultures from patients or normal controls. Therefore, the data do not provide evidence for a role for T-cell lymphotropic retroviruses as an etiology of schizophrenia.
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PMID:Lack of evidence for a role of T-cell-associated retroviruses as an etiology of schizophrenia. 246 91

Recent discoveries in the field of virus receptors have revolutionized our concepts of viral pathogenesis. The lysis of cells resulting from virus infection or immune recognition of infected cells is seen as merely one facet of a spectrum of pathogenic mechanisms which may be subtle and complex. This is particularly relevant to the central nervous and immune systems which share cell-surface receptors for various neuropeptides and neurotransmitters. A number of viruses are now known to share receptors for such endogenous ligands; indeed, some viruses (e.g., human immunodeficiency virus and vaccinia) may themselves be structural analogs of these ligands. There is, therefore, considerable scope for interference by viruses in the normal functioning of the brain and neuroendocrine systems. Brief reactive psychoses are occasionally reported as acute sequels to viral infections, but generally these are regarded as unrelated to schizophrenia. An opposite viewpoint is presented in the article: i.e., that the only reason these reactive psychoses do not progress to schizophrenia is that the majority of individuals affected are not predisposed genetically to schizophrenia. Conceivably, therefore, the genetic predisposition to schizophrenia may be attributable to genes which determine idiosyncratic differences in immune responsiveness to common viral pathogens.
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PMID:Scenarios for a viral etiology of schizophrenia. 305 71

For pharmaceuticals ranging from digitalis to vincristine the ethnobotanical approach to drug discovery has proven successful. The advent of high-throughput, mechanism-based in vitro bioassays coupled with candidate plants derived from pain-staking ethnopharmacological research has resulted in the discovery of new pharmaceuticals such as prostratin, a drug candidate for treatment of human immunodeficiency virus, as well as a variety of novel antiinflammatory compounds. Not all Western diseases are equally likely to be recognized by indigenous peoples. Gastrointestinal maladies, inflammation, skin infections and certain viral diseases are likely to be of high saliency to indigenous healers, whereas diseases such as cancer and cardiovascular illness are unlikely to be easily diagnosed by indigenous peoples. Yet indigenous remedies may indicate pharmacological activity for maladies such as schizophrenia, for which the biochemical mechanisms have yet to be discovered. Ethnopharmacological information can be used to provide three levels of resolution in the search for new drugs: (1) as a general indicator of non-specific bioactivity suitable for a panel of broad screens; (2) as an indicator of specific bioactivity suitable for particular high-resolution bioassays; (3) as an indicator of pharmacological activity for which mechanism-based bioassays have yet to be developed.
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PMID:The ethnobotanical approach to drug discovery: strengths and limitations. 773 59

Investigated was the prevalence of human immunodeficiency virus (HIV) among mentally ill criminal offenders admitted to Thailand's Nitichitawej Hospital for Forensic Psychiatric Services from September 1988-February 1989. There were 325 admissions; the average age was 32.4 years. 47% had committed murder or acts of grievous bodily harm, 33% were confined for offenses against property, and 6% were arrested for drug possession. In terms of psychiatric diagnoses, the majority (78%) were schizophrenic. 18 (5.6%) had a primary diagnosis of drug addiction, but 92 (28.3%) indicated they were substance abusers. Only 6 cases (1.8% prevalence) of HIV infection were found in this population. Four of the HIV-infected prisoners had a primary diagnosis of drug addiction; the remaining two were diagnosed with schizophrenia, but both these men had a history of substance abuse. When the HIV prevalence rate was recalculated for mentally ill patients who acknowledged a history of substance abuse, it increased to 33.33%; moreover, it rose to 35.29% when computed among those arrested on drug charges. These rates are consistent with those recorded among non-institutionalized drug abusers in Thailand (around 30%). It is recommended that forensic psychiatric units take precautions to prevent the spread of HIV through homosexual activity among inmates.
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PMID:The prevalence of HIV infection among mentally ill offenders in Thailand. 786 8

Patients with obsessive-compulsive disorder (OCD) demonstrated significant levels of antibody for somatostatin-28, its C-terminal fragment somatostatin-14, and prodynorphin. In contrast there were lower levels of reactivity for somatostatin-28(1-14) (the N-terminal fragment of somatostatin-28) and negligible reactivity for several other peptides including beta-endorphin and corticotropin. Healthy volunteers and disease controls [schizophrenia, Alzheimer's disease, multiple sclerosis, and subjects with advanced human immunodeficiency virus (HIV) infection] exhibited negligible reactivity. These data raise the consideration of an autoimmune mechanism for some OCD.
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PMID:Serum antibody for somatostatin-14 and prodynorphin 209-240 in patients with obsessive-compulsive disorder, schizophrenia, Alzheimer's disease, multiple sclerosis, and advanced HIV infection. 791 13

1. Magnetic resonance spectroscopy (MRS) is a powerful new neuropsychiatric research tool which allows for the noninvasive investigation of in vivo biochemistry. This review focuses on the recent applications of MRS to in vivo neuropsychiatric research. 2. The history of MRS as it has progressed from an in vitro method of biochemical analysis to its current in vivo research uses is presented. 3. A brief overview of the physical principles of MRS, including methods for spectral localization, is discussed. 4. Applications of the different MRS modalities (1H, 31P, 19F, 7Li, 13C and 23Na) to various neuropsychiatric disorders such as Alzheimer's disease, schizophrenia, affective disorders, acquired immunodeficiency disease, etc. are reviewed. The study of both fluorinated neuroleptics and the antidepressant fluoxetine using 19F MRS are discussed in greater detail. 5. Finally, potential future neuropsychiatric applications of MRS and specifically 19F MRS are presented.
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PMID:Nuclear magnetic resonance spectroscopy: a review of neuropsychiatric applications. 858 55

There is very little published information regarding the co-occurrence of human immunodeficiency virus (HIV)-spectrum illness and psychotic illnesses, including schizophrenia, even though their coexistence in the same patient may severely affect the course of both illnesses. Estimates of the frequency of HIV infection in patients with preexisting mental illness range between 5 and 7 percent. Estimates of new-onset psychosis in patients with HIV-spectrum illness range between 0.2 and 15 percent and may increase as the stage of HIV illness progresses. Regardless of which illness came first, their occurrence together appears to be associated with more morbidity and mortality than would be expected with either illness alone. Patients with new-onset psychosis respond to and tolerate relatively low doses of antipsychotic medication. Whether the presence of HIV decreases the effective daily dose of neuroleptic medication in patients with preexisting psychosis is not yet known. A clearly superior neuroleptic medication for patients with both psychosis and HIV infection has not yet been identified. Further systematic exploration is needed.
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PMID:Schizophrenia and HIV. 887 97


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