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Query: UMLS:C0021051 (immunodeficiency)
 71,517 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The medical files of 532 patients who underwent medically induced abortion over a 10-year period (1982-1991) in the French department of Ille-et-Vilaine were studied in order to evaluate the indications and outcomes. Among the patients, 358 resided in the department (67%). Comparatively with the number of births during the 10-year period, there was a relative increase in the number of medically induced abortions from 3.5/1000 to 5.5/1000. This parameter was taken into consideration for the interpretation of a parallel decrease in the perinatal mortality during the same period, from 5.9/1000 to 5.1/1000. There was a maternal indication in 91 cases which correspond to the former category of therapeutic induced abortions. There was a clear increase in 1991 corresponding to abortions induced because of extremely premature rupture of the membranes which were formerly allowed to continue to dead births. Foetal indications were frequent: 441 cases (83%). Exogenous causes were lower (15.6%), particularly due to the disappearance of indications resulting from maternal irradiation. For indications related to infection, the vaccination against rubella and improved prenatal diagnosis resulted in the disappearance of rubella as an indication during the last three years of the study and a clear decrease in the number of toxoplasmosis indications. There were few indications due to maternal infection by human immunodeficiency virus (4 cases). Chromosomal abnormalities were the main cause of medically induced abortion among the foetal indications (27.7%).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Reflections on 10 years of medically induced abortions in Ille-et-Vilaine]. 804 May 73

Two systems of time-resolved immunofluorometric assay (TR-IFMA), i.e., LKB system detection of viruses. The viruses detected were mainly adenovirus, influenza virus, parainfluenza virus, respiratory syncytial virus rotavirus, hepatitis B virus, human immunodeficiency virus, rubella virus, etc. Compared with methods of ELISA and RIA, TR-IFMA has the merits of high sensitivity, specificity and consistency with clinical diagnosis. The low detection limit of virus antigen by TR-IFMA is between 10-100 pg. The application of dual-label TR-IFMA also showed good effect. TR-IFMA can also be used in the detection of viral nucleic acids. The target region detected may reach the level of pg.
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PMID:[Application of the time-resolved immunofluorometric assay in the detection of viruses]. 815 83

Nurses often work in settings in which they may be exposed to a wide array of psychosocial, chemical, biological, and physical hazards. The authors outline several ways in which occupational exposures occur and the general process for reducing or preventing workplace hazards. Several commonly encountered workplace hazards and their potential health risks are identified and discussed. Specific health hazards that are addressed include the chemical hazards of antineoplastic and antiviral drugs; the biological hazards of human immunodeficiency virus, hepatitis B, herpes viruses, rubella, and tuberculosis; and the physical hazards of noise and ionizing and nonionizing radiation. The authors suggest specific preventive measures that nurses can take to make their workplaces safer.
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PMID:Health hazards of nursing: identifying workplace hazards and reducing risks. 824 54

Measles-mumps-rubella vaccine (MMR) is recommended for human immunodeficiency virus-infected (HIV+) adults. Data concerning MMR vaccination of HIV+ patients are limited to children. We evaluated 39 HIV+ (97% with > 200 CD4+ lymphocytes) and 17 non-HIV+ control adults receiving measles-rubella vaccine (MR). Clinical adverse events did not differ between groups. Prevaccination, three HIV+ and two control vaccinees were measles seronegative; no HIV+ and one control vaccinee seroconverted. No initially measles-seropositive vaccinee had a significant antibody elevation. Four HIV+ and three control vaccinees were rubella seronegative prevaccination; three HIV+ and two control vaccinees seroconverted. Among those initially rubella seropositive, two HIV+ and one control vaccinee had significant antibody elevations. There were no significant percentage CD4+ or CD8+ lymphocyte changes between groups. Three HIV+ vaccinees were p24 antigen positive pre- and postvaccination. Although MR vaccination appears safe in HIV+ adults, questions remain about the response of measles and rubella antibody-negative HIV+ adults and those with < 200 CD4+ lymphocytes.
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PMID:Response of human immunodeficiency virus-infected adults to measles-rubella vaccination. 834 Aug 90

To determine the immunogenicity of the measles and rubella components of the measles, mumps, and rubella virus (MMR) vaccine in human immunodeficiency virus (HIV)-infected children, we compared their response to that of uninfected controls. Sera were collected from HIV-infected patients and HIV seroreverters followed in our clinic and tested as close to 2 months post-MMR vaccination as possible. Specific IgG to both rubella and measles were measured by enzyme-linked immunosorbent assay. Of 20 children with HIV, 11 responded with adequate levels of antibody to measles. In the seroreverters, 12 of 13 responded. Of the measles responders, the median antibody level was significantly lower in the HIV-infected group than in the seroreverter group. In addition, HIV-infected responders tested at 9-15 months after vaccination demonstrated a significant decline in measles antibody levels. Although there was not a difference between the two cohorts in the proportion of patients who responded to the rubella component of the vaccine, there was a significant difference in the median antibody level of the responders of the two groups. We did not find a statistical difference in CD4 counts between responders and nonresponders. Alternate strategies will need to be established to prevent measles in HIV-infected children.
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PMID:Antibody response to measles and rubella vaccine by children with HIV infection. 841 Jun 69

Pregnant women are exposed to many biological, eg microbial, agents, which are potentially harmful to the fetus. The reported rates of vertical transmission of hepatitis B and human immunodeficiency virus vary between 3 to 90% and 0 to 65%, respectively. The susceptibility to hepatitis B and human immunodeficiency infection is increased in pregnant physicians, midwives, and nurses because of the bloodborne nature of these viruses. Also, TORCH (toxoplasmosis-rubella-cytomegalovirus-herpes) infections, acquired during pregnancy, may result in congenital infection, and serious sequelae in the neonatal period or years after birth. Schoolteachers and daycare personnel have an increased risk of perinatal varicella, "fifth disease," and mumps. Perinatal listeriosis affects one in 20,000 births and may result in fetal wastage. Because of the risk of the possibility of vertical transmission, immunization during pregnancy with live virus vaccines is not recommended.
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PMID:Biological agents and pregnancy. 852 Sep 61

We have investigated the prevalence of antibodies against Toxoplasma gondii, Trypanosoma cruzzi, Hepatitis B virus, cytomegalovirus, rubella virus, and human immunodeficiency virus in 139 adolescent pregnant women and in their high risk newborn children. The methods employed were the Sabin and Feldman reaction, complement fixation reaction, ELISA, and xenodiagnostic 30.9% of the pregnant group were seropositive for T. gondii, both mothers and newborns were IgM-negative. Two mothers (1.4%) presented anti T. cruzii antibodies, and one newborn child had circulating parasites. Related to the virological studies, 93.5% of the population were anti CMV antibodies positive and all their newborns were IgM (-) 90.6% of the adolescents were rubella positive and one was seropositive to VIH. We conclude that the prevalence found in this group of adolescent pregnant women are not significantly different to the one reported for the general pregnant women population.
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PMID:[Parasitic and viral marker detection in pregnant adolescents and their newborn infants at risk]. 855 94

The Advisory Committee on Immunization Practices (ACIP) recommends measles-mumps-rubella vaccine (MMR) for all persons asymptomatically infected with human immunodeficiency virus (HIV) and recommends that MMR be considered for all symptomatic HIV-infected persons who would otherwise be eligible for measles vaccine, because measles virus infection can cause severe illness and death in such persons. Serious or unusual adverse events in HIV-infected persons after receiving MMR have not been reported previously. This report summarizes the investigation of a case of progressive vaccine-associated measles pneumonitis in a person with acquired immunodeficiency syndrome and provides interim recommendations for the use of measles-containing vaccine among HIV-infected persons.
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PMID:Measles pneumonitis following measles-mumps-rubella vaccination of a patient with HIV infection, 1993. 867 52

1. Anesthetic gases, particularly nitrous oxide, have been investigated for potential reproductive, mutagenic, and carcinogenic effects. Waste gases have been found in high concentrations, even with work settings with scavenger systems in place. 2. Antineoplastic drugs, commonly used to treat persons with cancer, are virtually all considered to be embryo-fetal toxic. OSHA has issued comprehensive guidelines covering staff training, handling practices, and use of protective equipment. 3. The toxic effect of non-ionizing radiation has been a frequent topic of public and scientific debate. At this time no evidence exists of a reproductive hazard to health care workers. 4. Biologic agents such as rubella, hepatitis, cytomegalovirus, varicella, and human immunodeficiency virus frequently have the potential for adverse effects on the fetus. Administration of a vaccine or care of patients with active infection may be contraindicated in pregnancy.
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PMID:Reproductive hazards: an overview of exposures to health care workers. 869 64

The timely facilitation of immunologic (immunoglobulin or vaccine) or antimicrobial prophylaxis is used in individuals who have been exposed to certain infectious diseases. Such methodology has been shown to be helpful in infections such as viral hepatitis types A and B, measles, varicella, rabies, and tuberculosis. The data supporting such use in rubella and mumps are not strong and information is still needed in hepatitis C, human immunodeficiency virus, and Lyme borreliosis. This article reviews postexposure prophylaxis in these situations. Preventive strategies for meningococcal disease, group A streptococcus, tetanus, diphtheria, and pertussis are discussed elsewhere in this issue.
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PMID:Postexposure prophylaxis. 895 74


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