Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0021051 (immunodeficiency)
 71,517 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Apical periodontitis was induced in 24 mongrel dogs (16 experimental and 8 reference ones) over the course of total x-ray exposure. Analysis of clinical and physiologic data, hematologic parameters, and roentgenograms of the jaws of the two animal groups has shown the development of immunodeficiency state in the experimental animals due to exposure to ionizing irradiation in a dose of 1.5 Gy and an earlier development of destruction foci in bone tissue with diffuse involvement of the dental apexes.
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PMID:[The characteristics of the development of experimental apical periodontitis in irradiation-induced immunodeficiency]. 180 40

Apical periodontitis was simulated in 100 white rats with secondary immunodeficiency induced by a single total x-ray irradiation with the RUM [correction of PYM]-17 device. Nonspecific resistance of the rat body was assessed from the neutrophilic phagocytic activity, serum bactericidal activity, lysozyme and complement levels. These parameters were found reduced in the experimental animals; x-ray examinations revealed changes round the dental root apices. Daily injections of tactivin for 10 days in a dose 2-5 mg/kg b.m. resulted in elevation of the nonspecific resistance parameters, and the x-ray picture in this group of animals was the same as in intact controls; therefore, tactivin normalized the immunity system status and indirectly improved the clinical course of apical periodontitis.
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PMID:[The use of taktivin in experimental apical periodontitis exacerbated by a secondary immunodeficiency state]. 804 17