Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0021051 (immunodeficiency)
 71,517 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Primary immunodeficiency disorders (PIDs) are rare genetic diseases of the immune system. With improving awareness of PIDs among clinicians, the number of patients diagnosed with PIDs is rising rapidly in Southeast Asia. However, delayed diagnosis remains common and adversely affects the prognosis of these patients. In this review, we provide simple phenotypic approach to the diagnosis of PIDs based on pattern recognition. Through multi-centered collaborative studies in the Asian Primary Immunodeficiency Network (APID), we present unique patterns of infectious diseases associated with PIDs in Southeast Asia, including BCG disease, tuberculosis, melioidosis, Penicillium marneffei and Chromobacterium violaceum infections. These initial observations suggest the possibility of utilizing these infections that rarely affect normal healthy children as 'indicators' for PIDs, which is of particular relevance for clinicians working in Southeast Asia.
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PMID:Endemic infections in Southeast Asia provide new insights to the phenotypic spectrum of primary immunodeficiency disorders. 2405 98

A spinal epidural abscess (SEA) is a rare condition that has a devastating impact on the patient's health. It is difficult to diagnose and can present with a myriad of symptoms with or without the involvement of a neurological deficit. The conditions that lead to immunocompromised status, such as malnutrition, diabetes, intravenous drug abuse, previous surgical intervention, and human immunodeficiency virus (HIV) infection/acquired immune deficiency syndrome (AIDS) can predispose a patient to SEA. The most common organisms isolated from the affected patient include Staphylococcus aureus and Streptococcus species while an abscess in some cases can be caused by tuberculosis and fungal and parasitic infections. Among the other causative organisms is Burkholderia pseudomallei (B. pseudomallei), also known as Pseudomonas pseudomallei, which is a Gram-negative, bipolar, aerobic, motile, and rod-shaped bacterium. It is a soil-dwelling bacterium, which is endemic in tropical and subtropical regions worldwide, particularly in Thailand and northern Australia, and causes melioidosis. To our knowledge, SEA caused by B. pseudomallei from the Indian subcontinent has not been reported in the literature. In this case report, we present the case of a patient with SEA caused by B. pseudomallei.
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PMID:Spinal Epidural Abscess in Melioidosis: A Rare Case Report from Eastern India. 3110 87


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