Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020672 (hypothermia)
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Human Gene/Protein
RNASE4 protein 10.8
creatine kinase, mitochondrial 9.8
RNA-binding motif 3 9.8
RNA-binding motif protein 3 9.8
heat shock 70kDa protein 4 9.3
PHCA 9.3
RBM3 9.0
ZNF333 8.8
RNA binding motif protein 3 8.5
cold-inducible RNA-binding protein 8.5
bombesin-like peptide receptor 8.3
MMSDH 8.3
SIP3 8.3
14-3-3 beta protein 8.0
Hb-2 8.0
CIRP 8.0
CIRBP 8.0
potassium channel 2 7.7
cysteine/histidine-rich 1 7.7
PDHK2 7.7
N143 7.5
100kD 7.4
FBL3 7.3
HTK 7.1
ribonuclease 4 6.9
adenylyl cyclase type VI 6.9
HL-20 6.9
uncoupling protein 4 6.8
twinfilin 1 6.8
monocarboxylic acid transporter 1 6.8
RBM1 6.8
HOT 6.7
C1QC 6.7
SLC25A25 6.7
voltage-dependent anion channel 3 6.7
GABABR1 6.6
IRG2 6.5
Nicotinamide mononucleotide adenylyltransferase 1 6.5
Freud-1 6.5
CPB 6.4
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Disease
Pituitary coma 10.8
vagabond's disease 10.8
Aorticopulmonary paraganglioma 10.8
Semilobar holoprosencephaly 10.8
cold injury syndrome 10.8
inborn urea cycle disorder 9.8
Sopor 9.8
Algid malaria 9.8
ASD I 9.8
Dilutional anaemia 9.8
Circulatory arrest 9.7
Hypoxic-ischemic encephalopathy (HIE) 9.7
Neonatal encephalopathy 9.5
Myxedema coma 9.4
DIC in newborn 9.3
Acute coagulopathy 9.0
Citrate toxicity 8.8
Psychotic behavior 8.5
Staphylococcus aureus mediastinitis 8.5
Hypoxic-ischemic brain injury 8.2
Subendocardial ischemia 8.1
Hypophagia 8.1
Radiocontrast nephropathy 8.0
Cold panniculitis 8.0
erythrocyanosis 8.0
Vegetative endocarditis 8.0
Perinatal brain damage 7.9
Proximal myopathy 7.8
pregnancy infection 7.8
Primary congenital hypothyroidism 7.8
Congenital diaphragmatic eventration 7.7
swelling of the pituitary gland 7.5
stage IV Hodgkin's disease 7.5
Acute hyperkalemia 7.5
neonatal asphyxia 7.4
Relative polycythaemia 7.4
Uremic encephalopathy 7.4
catalepsy 7.3
Woakes' syndrome 7.3
Spinal cord ischemia 7.1
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Symptom
hypothermia 10.8
Induced hypothermia 10.5
Diaphragmatic flutter 8.8
Polypnea 8.8
Paroxysmal hypertension 7.1
Convulsive seizure 6.9
Fetal bradycardia 6.8
sinus headache 6.8
Very Low Birth Weight 6.8
Amputated 6.7
bradypnea 6.7
Mental status changes 6.6
muscular incoordination 6.3
aphagia 6.2
adipsia 6.1
abdominal rigidity 5.8
Pain and tenderness 5.8
hyperosmia 5.7
despair 5.6
POA 5.6
prostration 5.5
Todd's paralysis 5.5
labored breathing 5.4
tachypnea 5.4
Beau's lines 5.1
cardiovascular impairment 5.1
incoordination 5.1
Severe diarrhea 5.0
hypocapnia 5.0
neurological disability 5.0
Gasping 4.9
lethargy 4.9
GI irritation 4.9
Grimace 4.8
hypercapnia 4.8
Cold intolerance 4.7
staggering gait 4.7
diastolic murmurs 4.7
consciousness disturbance 4.6
oliguria 4.5
more...
Drug
Processed aconite root 10.8
Butaclamol hydrochloride 9.8
Lortalamine 9.8
Hirtonin 9.8
Dexamisole 8.8
Taltirelin hydrate 8.8
Wytensin 8.3
Valerianae radix 8.0
Lifarizine 8.0
Pituitrin 7.8
Wytensin 7.7
Olvanil 7.7
Afloqualone 7.7
Geodon 7.7
Timiperone 7.7
Oxypertine 7.5
Dopram 7.5
Flesinoxan 7.5
Kallidinogenase 7.4
Piclamilast 7.4
Piclamilast 7.4
Geodon 7.4
Benzonatate 7.1
Alaproclate 7.0
Levophed 6.9
Lubeluzole 6.8
Brevibloc 6.8
Medetomidine 6.6
Ziprasidone hydrochloride 6.5
Amfonelic acid 6.5
SUN 1165 6.5
Pirenperone 6.4
Pentolinium 6.4
Oxyphenbutazone 6.3
Sivelestat sodium hydrate 6.3
Haloperidol decanoate 6.3
Oxyphenbutazone 6.2
Doxapram 6.2
Atracurium besylate 6.2
Alacepril 6.1
more...
Enzyme
nicotine oxidase 5.7
trehalose phosphorylase 5.3
HPI 5.2
GMP reductase 5.1
N-acetylglucosaminyltransferase II 4.9
nardilysin 4.9
palmitoyl-protein thioesterase 4.8
butyryl-CoA dehydrogenase 4.4
gastricsin 4.3
isovaleryl-CoA dehydrogenase 4.3
CPR 4.2
BAT 4.1
FAST 4.1
LMT 4.0
monoacylglycerol lipase 4.0
CNPase 3.8
deoxyguanosine kinase 3.7
malonyl-CoA decarboxylase 3.6
SCP 3.6
LIS 3.6
fatty-acid synthase 3.6
adenosine kinase 3.6
GABA transaminase 3.5
DMT 3.5
creatine kinase 3.4
PNL 3.4
clotting enzyme 3.4
SPT 3.4
homogentisate 1,2-dioxygenase 3.3
phosphatidylinositol-4,5-bisphosphate 3-kinase 3.2
monoamine oxidase 3.2
DOPA decarboxylase 3.1
AAE 3.1
phosphatidylethanolamine N-methyltransferase 3.0
lactic acid dehydrogenase 3.0
lactic acid dehydrogenase 2.9
tissue plasminogen activator 2.9
CPL 2.8
thromboxane synthase 2.7
tryptophan hydroxylase 2.6
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Compound
2-ethyl-8-methyl-2,8-diazaspiro[4.5]decane-1,3-dione 10.8
Prednisolone sodium succinate 9.5
8-azaspiro[4.5]decane 8.8
2-hydroxy-3-methoxybenzoic acid 8.5
1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one 8.5
5-Iodotubercidin 8.3
5-Iodotubercidin 8.3
5-Iodotubercidin 8.3
N-(4-isopropylphenyl)acetamide 8.3
Iprindole 8.3
5-Iodotubercidin 8.1
U 14 8.0
Mepenzolate 8.0
beta-Amyrin 8.0
Ketaset 8.0
Sulfolane 8.0
Di-o-tolylguanidine 7.8
MIF-I 7.8
UH-301 7.7
5,5,5-trifluoroleucine 7.7
alpha-Methyltryptophan 7.7
Tetrahydrozoline 7.7
Iminodibenzyl 7.7
9-anthrol 7.5
Calcium pantothenate 7.5
Dopram 7.5
yohimban 7.4
2-(4-morpholinyl)ethyl 7.3
DHCA 7.3
Emopamil 7.3
MeODMT 7.2
2-(4-morpholinyl)ethyl 7.2
1,2,4,5-tetramethoxybenzene 6.9
p-Synephrine 6.9
alpha-Methylnoradrenaline 6.8
[6]-Shogaol 6.8
AHCT 6.8
Neotetrazolium 6.8
Mercaptoacetate 6.8
K486 6.8
more...