Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Proadifen (SKF 524 A) inhibited the following effects of imipramine (IMI), without affecting those of desipramine (DMI) in mice: antagonism towards reserpine-induced hypothermia, ptosis and sedation, antagonism to apomorphine hypothermia and insignificant shortening of the immobility time in the behavioral despair test. Cerebral levels of DMI were very low after administration of IMI; pretreatment with proadifen did not affect the already low levels of DMI but significantly elevated these of IMI. This may indicate that some other than DMI metabolites (e.g., 2-hydroxy-derivatives) may be of importance for the action of IMI in mice in the tests employed in this study.
Pol J Pharmacol Pharm
PMID:The effect of proadifen, a drug metabolism inhibitor, on action of imipramine and desipramine in mice. 718 47

Apomorphine (APO, 0.25 to 16 mg/kg) induced a dose dependent hypothermia in mice. Haloperidol, a dopamine antagonist, antagonized APO hypothermia due to lower doses. Clozapine and phenoxybenzamine, on the other hand, failed to modify APO hypothermia. Similarly, levopropranolol and cyproheptadine, which modify serotonergic responses, also failed to modify APO hypothermia. But fluxetine which selectively inhibits serotonin uptake, reversed APO induced hypothermia due to higher doses but not that induced by low dose of APO. The behavioral stereotypy was, however, not modified by fluoxetine pretreatment. It is concluded that APO hypothermia due to lower and higher doses are mediated by different receptors and the latter action involves the interaction of more than one type of receptor.
Pol J Pharmacol Pharm
PMID:Apomorphine hypothermia: interaction with serotonergic agents. 719 60

A psychopharmacological profile of mesterolone, an androgen and potential antidepressant drug, was tested in mice and rats. Given in a dose of 80 mg/kg ip, mesterolone potentiated the action of L-DOPA in mice and in doses 40 and 80 mg/kg ip potentiated the amphetamine stereotypy in rats. On the other hand, in doses of 20--80 mg/kg ip mesterolone did not affect the reserpine induced hypothermia and ptosis, did not antagonize the apomorphine induced hypothermia in mice, did not change the motor stimulation produced by amphetamine and did not affect the spiperone induced catalepsy in rats. Mesterolone did not affect the head twitch response after 5-hydroxytryptophan in mice and was inactive in the behavioral despair test in rats. The results indicate that the psychopharmacological profile of mesterolone only slightly resembles the profile of classical imipramine-like anti-depressants.
Pol J Pharmacol Pharm 1981 Oct
PMID:Psychopharmacological profile of mesterolone. 719 78

Mepiprazole, a phenylpiperazine derivative, strongly antagonizes the behavioral syndromes evolved by 5-hydroxytrypotophan. The drug did not affect the serotonin neurons in the preparation of flexor reflex of the hind paw of the spinal rat: in higher doses it depressed the reflex showing noradrenolytic properties. Mepiprazole antagonized the fenfluramine-induced hyperthermia, depressed spontaneous locomotor activity, produce hypothermia and was inactive in the despair test. The results suggest that mepiprazol may have noradenolytic properties; its possible influence on the serotonergic system is masked by noradrenolytic properties and hence difficult to demonstrate.
Pol J Pharmacol Pharm
PMID:Central action of mepiprazole. 725 66

Ketotifen (4-/1-methyl-4-piperidylidene/-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one hydrogen fumarate) inhibited spontaneous locomotor activity and amphetamine hypermotility in mice and rats, as well as L-DOPA-induced motor stimulation in mice. It produced in mice a slight hypothermia and did not prevent reserpine-induced hypothermia; thus, it does not posses properties or tricyclic antidepressants. Ketotifen showed some features of serotoninolytic: it inhibited the head twitch response to 5-hydroxytryptophan in mice, depressed tryptamine-induced clonic convulsions in rats, antagonized fenfluramine-induced hyperthermia in rats at high ambient temperature and showed weak antiserotonin action in the flexor reflex preparation. Ketotifen did not affect spiperone- or reserpine-induced catalepsy and showed no cholinolytic activity. LD50 of ketotifen (after 24 h) was 122.5 mg/kg ip in mice and 62.6 mg/kg ip in rats.
Pol J Pharmacol Pharm 1981
PMID:Central action of ketotifen. 733 54

The influence of proadifen (SKF-525-A), an agent inhibiting the metabolism of drugs, on the antidepressant action of imipramine (IMI) and desipramine (DMI) in rats was investigated. Proadifen antagonized the action of IMI when investigated in reserpine hypothermia and ptosis and in the behavioral despair test. The action of DMI in the same tests was not changed by proadifen. Proadifen lowered the level of DMI and increased the level of IMI in rat brains. The results permit to draw the conclusion that DMI plays an essential role in the action arising from IMI administration, that is, the noradrenergic--and not the serotonergic--mechanism is of essential importance.
Pol J Pharmacol Pharm 1981
PMID:Influence of proadifen, an inhibitor of the metabolism of drugs, on the action of imipramine and desipramine in rats. 734 8

Dexamisole antagonized the reserpine-induced hypothermia but was ineffective in the apomorphine-induced hypothermia in mice. It reduced ptosis produced by reserpine in mice but this effect was very weak. The effect of dexamisole on the amphetamine-induced hyperactivity depended upon the animal species. Dexamisole reduced the duration of immobility in the despair test in rats. It did not modify the 5-HTP-induced head twitch reaction in mice but produced stimulation of the hind limb flexor reflex in spinal rats. The latter effect was blocked by phenoxybenzamine but not by cyproheptadine and metergoline. Dexamisole also exerted a sedative and hypothermic effect. The above findings indicate that the pharmacological profile of dexamisole resembles in some respects that of tricyclic antidepressants; they also point out that this drug has a central noradrenergic activity.
Pol J Pharmacol Pharm
PMID:Psychopharmacological profile of dexamisole. 745 9

There are only few reports in the literature on the occurrence of hypothermia after chemotherapy. It occurred after various cytostatics and lasted for few hours to several days. Our material consisted of 11 patients with malignant lymphoma who were given chemotherapy protocols including cisplatin. In 5 patients (2 with Hodgkin's disease and 3 with non-Hodgkin's lymphoma) who had high fever, after treatment the temperature decreased down to 34.3 degrees C. Hypothermia disappeared spontaneously after few days. The drug responsible for this effect in our patients was cisplatin.
Pol Arch Med Wewn 1995 Feb
PMID:[Hypothermia during chemotherapy for lymphomas]. 747 30

The 5-HT1A antagonistic properties of (+)-N-tert-butyl-3-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenyl pro panamide ((+)WAY 100135) were studied. Its effect on the 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)-induced behavioral syndrome (flat body posture and reciprocal forepaw treading) in reserpine-pretreated rats, the stimulus effect in a drug discrimination model in rats, the lower lip retraction in rats, the hypothermia in mice and secretion of corticosterone in rats, i.e. responses mediated by 5-HT1A receptors, were examined. (+)WAY 100135 administered in doses up to 10 mg/kg dose-dependently antagonized all the above responses to 8-OH-DPAT, the lowest effective doses ranging from 1.25 to 2.5 mg/kg. At the same time, (+)WAY 100135 alone given in doses of 1.25-10 mg/kg did not mimic the activity of 8-OH-DPAT in the tests used. Our results indicate that (+)WAY 100135 is an antagonist of pre- and postsynaptic 5-HT1A receptors devoid of agonist properties.
Pol J Pharmacol
PMID:Antagonism of (+)WAY 100135 to behavioral, hypothermic and corticosterone effects induced by 8-OH-DPAT. 798 67

The influence of verapamil, nifedipine and cinnarizine on clonidine-induced hypothermia, spontaneous and explorative motility was investigated in mice. Verapamil 5 and 15 mg/kg, nifedipine 17.5 and 50 mg/kg and cinnarizine 75 and 200 mg/kg (that is 1/30 and 1/10 of LD50 respectively) were injected intraperitoneally. The drugs were given in single doses (1/10 LD50) and in repeated doses (1/30 LD50) during a 10 days course. In acute experiments the drugs were given 60 min before clonidine administration, while in chronic experiments clonidine was given on the 11th day of the experiment. Nifedipine prevents clonidine-induced hypothermia in both the applied doses, verapamil only in a single dose, and cinnarizine in repeated doses. Only repeated administration of nifedipine and cinnarizine weakens the clonidine-induced sedation in the studies of spontaneous motility, and as for nifedipine also in explorative motility.
Pol J Pharmacol
PMID:The influence of calcium channel blockers on the central action of clonidine. 800 Apr 43


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