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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied the ability of opioid antagonists: naloxone, naltrexone and diprenorphine and an opioid agonist morphine to influence the effects of ethanol on hypothermia, sleeping time and impairment of aerial righting reflex. Naltrexone (2-16 mg/kg) and naloxone (2-16 mg/kg) were not able to attenuate effects of ethanol, while diprenorphine decreased ethanol sleeping time (4 microgram/kg) and antagonized the ethanol hypothermia (8 microgram/kg). Naltrexone in a dose of 8 mg/kg sc antagonized the ethanol impairment of aerial righting reflex. The present behavioral studies did not provide any evidence for the participation of the opioid system in the mediation of acute ethanol effects in rats.
Pol J Pharmacol Pharm
PMID:The lack of effect of opioid agonists and antagonists on some acute effects of ethanol. 227 71

The synthesis and properties of 13H-naphtho[1',2':7,6] [1,4] diazepino[2,3-b] pyridines (7a--g) were described. New compounds were studied in rats and in mice in the tests used for preclinical assessment of antidepressant or anxiolytic activity. Compound 7c showed weak antagonism towards the reserpine-induced hypothermia and shortened immobility time in the despair test. None of the tested compounds had an anxiety-relieving action.
Pol J Pharmacol Pharm
PMID:Synthesis and pharmacological properties of 13H-naphtho[1',2':7,6] [1,4] diazepino[2,3-b] pyridines. 227 74

Are ascending noradrenergic and serotonergic pathways necessary for effects of electroconvulsive treatment? Clonidine hypothermia and forced swim study. W. DANYSZ , W. KOSTOWSKI, M. HAUPTMANN, A. BIDZINSKI. Pol. J. Pharmacol. Pharm., 1989, 41, 15-22. Influence of chemical lesions to the noradrenergic locus coeruleus (intracerebral 6-OHDA injection, systemic administration of DSP-4) and serotonergic raphe system (intracerebral 5,7-DHT) on some effects produced by electroconvulsive shock (ECS) was studied. Administration of ECS slightly but significantly attenuated clonidine (CLO)-induced hypothermia and reduced rats immobility in forced swim test. DSP-4 reduced ECS action on CLO hypothermia remaining without effect upon ECS action in the second test. Other lesions were ineffective in both tests. This finding is in contrast to results obtained previously in animals receiving desipramine. The possible difference between ECS and antidepressant drugs action is discussed.
Pol J Pharmacol Pharm
PMID:Are ascending noradrenergic and serotonergic pathways necessary for effects of electroconvulsive treatment? Clonidine hypothermia and forced swim study. 251 61

8-OH-DPAT and ipsapirone were studied in rats and mice in the tests used for preclinical assessment of antidepressant activity, 8-OH-DPAT shortened the immobility time in the behavioral despair test in rats and mice and counteracted the hypothermia induced by reserpine or apomorphine, whereas ipsapirone revealed only a weak activity in the despair test in rats but not in mice, and was inactive in the hypothermia induced by reserpine or apomorphine. The antireserpine action of 8-OH-DPAT was reduced by haloperidol and also by ipsapirone less potently, though. The obtained results indicate that 8-OH-DPAT acts similarly to typical antidepressants in behavioral tests regarded as specific, whereas ipsapirone is devoid of such an action.
Pol J Pharmacol Pharm
PMID:Effects of 8-OH-DPAT and ipsapirone in the tests used for evaluation of the antidepressant action. 253 21

The study examined the effect of both oxaprotiline (OXA) enantiomers on the serotonin system in rats and mice. (+)-OXA and (-)-OXA partly inhibit the behavioral syndrome induced by 8-OH-DPAT and 5-methoxy-dimethyltryptamine (5-MeODMT) in normal and reserpinized rats. Imipramine and desipramine produced a similar but less potent effect. (+)-OXA and, to a lesser extent, (-)-OXA antagonized the m-chlorophenylpiperazine (m-CPP)-induced hypothermia in mice. Imipramine and desipramine produced no such effect. (+)-OXA attenuated the head-twitch response to L-5-HTP in mice, but (-)-OXA has no such action. Neither enantiomer inhibited the fenfluramine-induced hyperthermia in rats nor antagonized m-CPP-induced stimulation of hind limb flexor reflex of spinal rat. The obtained results indicate that both enantiomers may have a 5-HT1B-antagonistic action and a less potent 5-HT1A-antagonistic one; on the other hand, they shown no 5-HT2-antagonistic activity.
Pol J Pharmacol Pharm
PMID:Pharmacological effects of oxaprotiline enantiomers on the central serotonin system. 253 22

The central action, particularly potential antidepressant activity of WEB 1881, a new nootropic drug related to piracetam, was investigated in rats and mice. WEB 1881 antagonizes the reserpine- and apomorphine-induced hypothermia, potentiates the behavioral effect of DOPA and dihydroxyphenylserine, as well as the TRH-induced hyperthermia. Piracetam was only effective in the reserpine and DOPA tests. WEB 1881 is inactive in immobility test of Porsolt et al. It enhances the hind limb flexor reflex of the spinal rat, this effect being antagonized by prazosin and cyproheptadine. It exerts no effect on head twitches induced by L-5-hydroxytryptophan. The studied compound increases the noradrenaline and dopamine and turnover in the forebrain and brain stem. WEB 1881 given repeatedly potentiates the clonidine-induced aggressiveness and has no effect on the locomotor hyperactivity induced by D-amphetamine. The results indicate that in a number of tests WEB 1881 acts like other antidepressant drugs (but in others not), moreover, they suggest that this action is--at least partly--mediated by the central noradrenaline system.
Pol J Pharmacol Pharm
PMID:Antidepressant activities of WEB 1881, a new nootropic agent. 256 89

Newly synthesized derivatives of 1-diphenylacetamide-2-butanol were investigated pharmacologically for their central properties in mice and rats. The most active were 2 compounds: racemic (RS) and enantiomer S (+) form of N-diphenylacetamide-2-butanol which produced hypothermia in normothermic mice, showed anxiolytic action in the four-plate test and reversed reserpine-induced hypothermia.
Pol J Pharmacol Pharm
PMID:Synthesis and pharmacological properties of new derivatives of 1-diphenylacetamide-2-butanol. 257 62

The central action of 1-(2-pyrimidinyl)-piperazine (1-PP), a metabolite of ipsapirone, was studied in mice and rats. 1-PP decreased the locomotor activity and slightly increased the body temperature at an ambient temperature of 21 degrees C, not changing it at an ambient temperature of 28 degrees C. The examined substance antagonized clonidine effects (hypothermia, locomotor hypoactivity, stimulation of the hind limb flexor reflex of the spinal rat). Stimulation of the flexor reflex by St 587, an alpha 1-adrenoceptor agonist was not blocked by 1-PP. 1-PP-induced stimulation of the flexor reflex was blocked by cyproheptadine, ketanserin and pirenperone, but not by prazosin or yohimbine. Given in high doses, 1-PP evoked a flat body posture syndrome, but not forepaw treading or head twitches. The obtained results indicate that 1-PP has mainly an alpha 2-adrenolytic action and differs from ipsapirone in its profile.
Pol J Pharmacol Pharm
PMID:The central action of 1-(2-pyrimidinyl)-piperazine, an ipsapirone metabolite. 258 37

The effect of a combined treatment with ethanol and imipramine or amitriptyline was tested in mice and rats. The antidepressants were given in one or, in some experiments, in 21 daily doses of 10 mg/kg each. In mice the effect of antidepressants was tested on acute toxicity, disturbances of rota-rod performance, hypothermia and sleeping induced by ethanol, in rats the effect of the antidepressants on the development of tolerance to sleep-inducing and hypothermic action of ethanol was investigated. Amitriptyline showed a tendency to pontentiate the ethanol-induced acute toxicity, while imipramine did not change it. Given in a single dose the antidepressants have a tendency to potentiate the impairment of motor coordination induced by ethanol, but after a prolonged administration did not influence the ethanol effect in the rota-rod test. The antidepressants enhance ethanol-induced hypothermia and prolong the ethanol sleeping time. The development of tolerance to hypnotic effect of ethanol in rats is not affected by amitriptyline and imipramine, but the antidepressants prevent the development of tolerance to hypothermic effect.
Pol J Pharmacol Pharm
PMID:Interaction between central effects of ethanol and tricyclic antidepressants, imipramine and amitriptyline in mice and rats. 261 81

A potential antidepressant activity of B-193 was studied in mice and rats. In in vitro studies B-193 did not affect the uptake of NA and 5-HT. In in vivo models the tested compound did not influence the reserpine-induced hypothermia, hypoactivity and ptosis, the stimulating action of L-DOPA, the apomorphine-induced hypothermia. On the other hand, it produced a positive effect in the despair test. When given repeatedly, it evoked adaptive changes in brain neurotransmitter receptors, i.e. it decreased the density of beta-adrenoceptors and increased the number of alpha 1 ones; those changes were accompanied with functional alternations in the reactivity of those receptors: an attenuated behavioral reaction to salbutamol and enhanced aggressiveness induced by a high dose of clonidine. Furthermore, B-193 administered repeatedly enhanced hyperlocomotion induced by amphetamine but did not influence the stereotypy induced by apomorphine. These results indicate that B-193 possesses properties characteristic for atypical antidepressants.
Pol J Pharmacol Pharm
PMID:Antidepressant profile of 9-methyl-2[-3-(4-phenyl-1-piperazinylpropyl)]-1,2,3,4-tetrahydro-beta- carbolin-1-one (B-193). 263 91


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