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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of serotonin precursors, tryptophan (TP) and L-5-hydroxytryptophan (5-HTP), administered together with peripheral decarboxylase inhibitor -- Ro 4-4602 on the rectal body temperature of rats was studied. TP caused a significant hypothermia which was prevented by pretreatment with p-chlorophenylalanine (PCPA), the serotonin synthesis inhibitor. 5-HTP did not influence the body temperature or slightly decreased it. However, the significant hypothermizing effect of 5-HTP was observed in rats pretreated with spiroperidol, haloperidol or phenoxybenzamine. Methysergide or cyproheptadine -- compounds regarded as potent serotonin receptor blockers -- did not prevent the TP-induced hypothermia. In methysergide pretreated rats 5-HTP produced a considerable hyperthermia. Cyproheptadine did not influence the effects of 5-HTP on the body temperature. The results obtained suggest that cyproheptadine and methysergide fail to block those central serotonin receptors which produce hypothermia after their stimulation.
Pol J Pharmacol Pharm
PMID:The influence of serotonergic agents on the body temperature. 13 32

Bilateral intraventricular injections of high dose (2 X 250 microgram) of 6-hydroxydopamine to rats pretreated with nialamide produced a pronounced hyperactivity persisting for several hours and induced permanent aggressiveness. Only 50% rat survived the treatment for longer than a week, the explorative activity of the survivors was inhibited for over 2 months. The brain catecholamine content was depressed for at least 15 months, while no long-term changes of serotonin level were observed. The hyperactivity, aggressiveness and hypothermia produced by apomorphine were enhanced in centrally chemosympathectomized rats, while the hyperactivity produced by D-amphetamine or amantadine remained inaffected. The results confirm the development of dopamine receptor supersensitivity following central chemosympathectomy, and indicate a possibility of employing the supersensitivity model for distinguishing between pre- and postsynaptic action of dopaminergic stimulants.
Pol J Pharmacol Pharm
PMID:Short- and long-term effects of intraventricular 6-hydroxydopamine in rats pretreated with a monoamine oxidase inhibitor. 56 59

Piribedil produces a pronounced hypothermia both in mice and rats. This hypothermia was prevented by previous administration of dopamine receptor blocking agents (spiperone in mice and rats, pimozide in mice), tricyclic antidepressant drugs (imipramine, clomipramine, desipramine) in mice and LSD in rats. Administration of agents acting on serotonin receptors (cyproheptadine, p-chlorophenylalanine) or of a classical anticholinergic drug, atropine, did not change the hypothermizing effect of piribedil in rats. Thus, the hypothermia produced by piribedil is apparently similar to that produced by apomorphine. The possibility of a secondary stimulation of serotonergic receptors through direct stimulatory action of piribedil on dopamine neurons is discussed.
Pol J Pharmacol Pharm
PMID:The effect of piribedil on body temperature in mice and rats. 60 Aug 60

Effect of low body temperature on gastric secretory activity in the guinea pig under urethane general anaesthesia. Acta Physiol. Pol., 1978, 29 (1): 61-66. The effect of low body temperature on spontaneous and histamine (H) stimulated or Nalpha Nalpha-dimethylhistamine (NDMH)-stimulated gastric secretion was investigated in the guinea pig under general anaesthesia with urethane. In normothermia NDMH had a stronger stimulatory action on acid secretion In hypothermia (30 degrees C and 25 degrees C) only NDMH showed some stimulating effect. The obtained results point to the necessity of strict controlling of body temperature in the experiments performed on animals under general anaesthesia and suggest that the lack of effect at low temperature may be connected with an inhibition of the processes of H side-chain methylation when the rate of metabolic processes in the organism has fallen.
Acta Physiol Pol
PMID:Effect of low body temperature on gastric secretory activity in the guinea pig under urethane general anaesthesia. 66 50

5-hydroxydopamine, unspecific centrally acting false neurotransmitter. Acta Physiol. Pol., 1977, 28 (1): 13-22. 3,4,5-trihydroxyphenetylamine-5-hydroxydopamine (5-OHDA) injected intracerebro-ventricularly decreases the level of noradrenaline, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in different parts of the rat brain. It does not affect acetylcholine level. 5-OHDA causes dose-dependent hypothermia, transient hypertension and depression of locomotor and exploratory activity in rats. This behavioral phenomena are reversed by central chemical sympathectomy elicited by 6-hydroxydopamine. It is concluded that 5-OHDA is an unspecific centrally acting false transmitter.
Acta Physiol Pol
PMID:5-hydroxydopamine, unspecific centrally acting false neurotransmitter. 86 21

Ergometrine (EGM), 40 mg/kg ip or 100 microgram ivc, produces strong and long-lasting increase of locomotor activity of the rat, completely prevented by pretreatment with spiperone, 0.4 mg/kg, ip, or pimozide, 4 mg/kg ip. Given at a dose of 100 microgram ivc EGM produced a deep hypothermia, resistant to spiperone pretreatment (0.4 mg/kg ip). EGM decelerates cerebral serotonin (5-HT) turnover in mice and rats as measured by accumulation of 5-hydroxyindoleacetic acid after pretreatment with probenecid, and depresses the accumulation of 5-HT in the rat brain stem after pretreatment with pargyline. EGM potentiates the hind limb flexor of spinal rat. This effect is blocked by cyproheptadine (1 mg/kg ip) and danitracen (3 mg/kg ip). The results indicate that EGM stimulates both dopamine and 5-HT receptors in the central nervous system.
Pol J Pharmacol Pharm
PMID:Dopaminergic and serotonergic effects of ergometrine. 88 3

Bilateral lesion of caudate nucleus or substantia nigra as well as brain transsection between telencephalon and diencephalon potentiates the body temperature fall produced by apomorphine (5 mg/kg). A lesion of nucleus accumbens septi did not prevent the hypothermia, but slightly shortened its duration. Electrolytical and chemical (with 5,6-dihydroxytryptamine) lesions of both dorsal and medial raphe nuclei alleviated the hypothermia produced by apomorphine. The lesion of medial raphe nucleus did not affect, while the lesion of dorsal raphe nucleus prevented the hypothermia induced by apomorphine or piribedil (25 mg/kg). The results show that dopaminergic neurons of telencephalon are not involved in the mechanism of induction of apomorphine hypothermia, while the neurons of dorsal raphe nucleus participate in it.
Pol J Pharmacol Pharm
PMID:The effect of lesions of dopaminergic and serotonergic systems on apomorphine-induced hypothermia in the rat. 88 2

LiCl administered for 4 days enhances amphetamine-induced locomotor stimulation, increases amphetamine toxicity in aggregated mice but does not affect amphetamine stereotypy. Administered together with nialamide, LiCl increase locomotor activity of mice and rats. The administration of this compound together with reserpine reverses central effects of its action (hypothermia, decreased motility, enhancement of hexobarbital activity).
Pol J Pharmacol Pharm 1976
PMID:The effect of lithium chloride on the activity of some psychotropic drugs. 94 63

Ergometrine, a spasmolytic which also stimulates dopamine receptors, was investigated as a potential central stimulant. It did not influence the locomotor activity of normal rats and mice, and in high doses even depressed it. The locomotor activity depressed by reserpine, spiroperidol, and pimozide was elevated by ergometrine. Ergometrine antagonized neuroleptic-induced catalepsy and abolished ptosis and hypothermia produced by reserpine. Given alone ergometrine depressed the body temperature in rats and mice, and this effect was abolished by pimozide in both species, and by spiroperidol and haloperidol in mice. The hypothermia was not antagonized by atropine. In several respects the central action of ergometrine resembles that of apomorphine.
Pol J Pharmacol Pharm
PMID:Central action of ergometrine. 103 20

In the presented article, the course and results of anatomical correction of transposition of great arteries (TGA) in 7 neonates (2 females and 5 males) with mean body mass of 3250 g and 2 to 5 days old (mean 3 days) are reviewed. Surgery was performed in moderate hypothermia. St. Thomas cold cardioplegia was used. Mean aortic clamping time was 70 min (55-115), and the time of extracorporeal circulation was 165 min (117-210). Low cardiac output in all patients in the postoperative period required prolonged mechanical ventilation and positive inotropic drugs. Out of 7 patients operated, two died (29%). The cause of death in both cases was myocardial ischemia of right ventricle. The other 5 patients were discharged after healing of operational wound. In the control echocardiographic examination performed 3 to 12 months postoperatively, apart from one case of moderate pulmonary artery stenosis, no other haemodynamically significant complications were noted.
Kardiol Pol 1992 Aug
PMID:[Anatomical correction of transposition of the great arteries in 7 newborn infants]. 143 31


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