Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Local ocular hypothermia has been introduced as a possible alternative to performing intraocular surgery at the room temperature. The authors evaluated experimentally the effect of prolonged local hypothermia on the ERG. 22 rabbits underwent pars plana vitrectomy followed by continuous irrigation of the vitreous cavity for 1 hour. In the right eye, the temperature of the irrigating solution was 7 degrees C which lowered the intravitreal temperature to 15 degrees C; in the left eye, the solution was at room temperature and the intravitreal temperature was 24 degrees C. Flash ERG was performed pre-operatively and one week postoperatively on all eyes. There was no statistically significant difference in the post-operative ERG changes between the right and left eyes. The authors concluded that no harmful ERG changes were detected as near as 1 week following exposure to hypothermia for 1 hour.
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PMID:[Electrophysiological changes of the retina after hypothermic vitreous surgery]. 262 Jun 21

The purpose of this study was to test the hypothesis that ischemia/reperfusion injury in the rat retina may be ameliorated by reducing retinal metabolism with either hypothermia or inhibitory GABA agonists. The intraocular pressure of each right eye in rats was raised to 130 mm Hg for 60 min with the left eye serving as normal control. The rats were divided into four groups in terms of drug and hypothermia treatment: (1) Untreated ischemia, (2) Hypothermia, (3) Baclofen/midazolam and (4) Baclofen/muscimol. Electroretinogram was recorded before ischemia and again after 10-day reperfusion. Histological analysis with H&E staining and cell counts was performed. Untreated ischemia/reperfusion resulted in severely reduced ERG responses. The ERG b-wave was reduced from 423+/-144 microV to 130+/-91 microV (mean+/-SD, n=5). With hypothermia the ERG b-wave was reduced from 499+/-80 microV to 237+/-111 microV (n=4). With combinations of baclofen and midazolam the ERG b-wave was reduced from 432+/-96 microV to 104+/-67 microV (n=7). In baclofen/muscimol treated eyes the ERG b-wave went from 426+/-101 microV to 148+/-118 microV (n=6). The histological tissue damage was severe in untreated ischemia and the baclofen/midazolam and baclofen/muscimol groups, but less severe in the hypothermia group. The GABA agonists do not provide any protection in our ischemia/reperfusion model. Our results are consistent with earlier reports that hypothermia may be helpful in ischemic conditions in the retina.
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PMID:GABA agonists fail to protect the retina from ischemia-reperfusion injury. 1910 44