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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In man hypothermia exists when core temperature (Tc) falls below 35 degrees C. The onset of hypothermia is often insidious in that it can occur without any particular symptoms of serious discomfort. There is evidence that this decrease in thermosensitivity is most likely to occur when the rate of body cooling is slow. In addition there is some evidence that the susceptibility to become hypothermic varies with the circadian rhythm of Tc, particularly in animals maintained under constant light conditions. A systematic investigation has been carried out to determine whether the thermoregulatory response to body core cooling is affected by the rate of change of body temperature, the time of day at which the cooling takes place and/or by the light regime under which the animals are maintained. The investigation was made in rabbits maintained either under a 12-h light/dark (LD) cycle or under conditions of continuous light (LL). Thermosensitivity (relationship between falling Tc and the induced increase in metabolic heat production) was determined at two different rates of body cooling (1 degrees C decrease in core temperature in either 30 or 160 min.) and at different times of the day. A chronically implanted intravascular heat exchanger was used to extract heat from the animals. The results indicate that neither the rate of body cooling nor the time of day at which the cooling took place had any clear effect on the shivering response. Likewise there was no clear difference in the shivering response of the animals maintained under (LD) conditions as compared to those maintained under (LL) conditions.
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PMID:The effect of rate of cooling, time of day and light regime on the shivering response in rabbits. 152 28

Because of the shortage of cadaveric donor organs, living donor liver transplantation (LDLT) has become an established therapy modality for end-stage liver disease. Based on recipient size, both right and left liver lobe grafts have been used successfully in LDLT. The aim of this study was to compare the risk of intraoperative complications and transfusion requirements between right and left lobe donors. We reviewed the charts of 54 right lobe (Group RL), 29 left lobe (Group LL), and 31 left lateral segment (Group LLS) donors who underwent lobectomy from January 2003 through January 2007. We recorded patient demographics, perioperative laboratory values, intraoperative fluid and transfusion requirements, intraoperative hemodynamic parameters, and complications. Demographic features and preoperative laboratory values were similar for the 3 groups, except for age (Group RL, 37.3 +/- 8.7; Group LL, 36.0 +/- 9.3; Group LLS, 31.7 +/- 9.4; P = .02). There were no significant differences in mean liver volumes among the groups (P > .05). Respective graft volumes were 803.1 +/- 139.2 mL, 438.0 +/- 122.7 mL, and 308.2 +/- 76.6 mL for Groups RL, LL, and LLS, respectively (P < .001). More patients in Group LLS required heterologous blood transfusion than did those in the other groups (P = .01). The incidence of intraoperative hypotension was similar for all groups (P > .05). Group RL had a significantly higher rate of intraoperative hypothermia than the other groups (P = .01). There were no intraoperative respiratory complications or cardiac events. These results indicated that both right and left donor lobectomies for LDLT were safe procedures with acceptable rates of minor intraoperative complications.
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PMID:A comparison of right and left lobectomies for living donor liver transplantation: an anesthesiologist's point of view. 1826 46