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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rat pups of both genders were treated during the entire postnatal brain growth spurt (postnatal days 1-20) with ethanol (EE) utilizing an intragastric intubation technique. Two other groups of pups included isocaloric vehicle and handled control pups. Beginning on postnatal day 43 (TD1), and every seventh day subsequently (TD's 2, 3 and 4), the rats received an intraperitoneal dose of 2.2 g/kg ethanol. Their body temperatures were recorded at 0, 30, 60 and 90 minutes postinjection by use of a rectal probe. On the six days between measurements of ethanol-induced hypothermia, all rats were administered a daily dose of ethanol by intragastric intubation. Body growth of male and female pups was inhibited throughout the early treatment period. Body growth of adult females, but not males, was also depressed on TD's 1 and 2. Basal body temperature of EE male rats was selectively depressed at TD2, compared to the other groups. Although all groups showed tolerance to ethanol-induced hypothermia by TD2, there was a significant difference between males and females. Specifically, EE female rats showed a greater degree of tolerance when compared to EE males or control females.
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PMID:Tolerance to ethanol-induced hypothermia in adult rats following postnatal ethanol exposure. 226 Oct 90

The effect of lindane (gamma-HCH) on temperature, food intake and body weight was studied in male and female rats after single or repeated non-convulsant oral doses. A single dose of 30 mg/kg induced a significant decrease of core temperature (0.4 degrees C in males and 0.66 degrees C in females) 5 h after administration when compared to the control value. Lindane-induced hypothermia was strongly potentiated (1.45 degrees C) by cold stress when rats were kept at 4 degrees C. The same dose of lindane produced a significant decrease in body weight gain (-85% in males and -219% in females compared to the control gain), accompanied by a diminution of food intake, 24 h after administration. No decrease in both parameters was observed when alpha- or delta-HCH isomers 30 mg/kg were tested. After daily administration with 10 mg/kg lindane for 7 days, no hypothermic effects were observed. However, a slight but significant decrease in body weight gain was recorded over the treatment period. This effect was also accompanied by a reduced food intake. The observed stereoselective effects of HCH isomers on core temperature and body weight could be a useful model to study the mechanisms of lindane neurotoxicity at low subconvulsant doses.
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PMID:The effect of non-convulsant doses of lindane on temperature and body weight. 245 46