Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Behavioural and some neurochemical effects of Ro 40-7592 (3,4-dihydroxy-4'-methyl-5-nitrobenzophenone), a new COMT inhibitor, were studied in rats and mice. Ro 40-7592 increased the effect of L-DOPA (plus benserazide) on locomotor activity, reserpine-induced hypothermia, and catalepsy induced by pimozide, haloperidol and fluphenazine. Locomotor hyperactivity induced by amphetamine or nomifensine, as well as stereotypy induced by amphetamine (but not apomorphine), were also increased by Ro 40-7592. The drug stimulated exploratory activity in the open field test. It decreased the levels of HVA and 3-MT, increased the level of DOPAC but did not change the levels of dopamine in the striatum, nucleus accumbens and frontal cortex. These results indicate that Ro 40-7592 may improve the therapy with L-DOPA (plus decarboxylase inhibitor) of Parkinson's disease.
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PMID:Behavioural and neurochemical effects of Ro 40-7592, a new COMT inhibitor with a potential therapeutic activity in Parkinson's disease. 197 8

The inotropic and chronotropic responses of guinea pig atria, and the relaxation responses of guinea pig intestine, trachea, lung, uterus and vas deferens to catecholamines have been examined at bath temperatures of 38 degrees C and 30 degrees C. Hypothermia resulted in a supersensitivity of cardiac tissues with a decrease in isoprenaline EC50 and an increase in the maximum response to the partial agonist, salbutamol. Ileum responses to isoprenaline were potentiated at 30 degrees C but no partial agonist could be found on this tissue. Responses of the lung and vas deferens to partial agonists were not affected by temperature, while uterine responses were inhibited by hypothermia. The trachea was supersensitive to isoprenaline at 30 degrees C, however this was not due to a change in beta-adrenoceptor sensitivity but an inhibition of COMT. Partial agonist responses of trachea were similar at both temperatures. beta-Adrenoceptor supersensitivity was therefore observed only where responses are mediated primarily by beta 1-adrenoceptors and supports the concept that beta 1- but not beta 2-adrenoceptors exhibit hypothermia-induced supersensitivity.
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PMID:Temperature dependence of beta 1-adrenoceptor-mediated responses examined by use of partial agonists. 285 94