Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mild barbiturate-moderate hypothermia therapy was established for severe head injury and cerebrovascular disease. This study was conducted on 152 patients from April 1984 through July 1995. In this study were included patients with Glagow Coma Scale score of less than 8 points but those with serious systemic complications and elderly and infantile patients were excluded. Our protocol consisted of administration of thiamylal Na 1.25-2.5 mg/kg/h and droperidol 20-40 micrograms/kg/h (mild barbiturate) while maintaining a core temperature of 32-34 degrees C (moderate hypothermia). The clinical outcome was good (GR, MD) in 58 cases, poor (SD) in 24 cases and bad (PVS, D) in 70 cases. This therapy was found to be particularly effective for preventing ischemic neurological damage in the vasospasm stage following SAH and severe head injury in young patients. However, this therapy did not prevent pneumonia, cardiac failure, arrhythmia and hypopotassemia from occurring frequently. We conclude that this therapy is contraindicated in the elderly, i.e., those older than 65 years.
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PMID:[Analysis of mild barbiturate-moderate hypothermia therapy on the authors' 152 cases]. 918 90

The outcome of acute subdural hematoma (ASDH), which can cause severe parenchymal injury, has generally been unsatisfactory. The standard surgical procedure for ASDH is a quick and wide opening by dural incision, removal of the subdural and contusional intracerebral hematoma, followed by large external and internal decompression. In this study, we assessed our therapeutic strategy, consisting of three principles: 1. Removal of subdural hematoma by wide craniotomy-small dural incisions, in well-decompressed case, connecting the small dural incisions and stanching the bleeding points on the cortical surface but not proceeding with contusional hemorrhage in emergency operations, 2. Post-operative induction of mild barbiturate-moderate hypothermia therapy and 3. Intentionally delayed evacuation of the intracerebral contusional hemorrhage when needed. The patients, profile is composed of an old therapy group (27 cases) and a new therapy group (20 cases) suffering from ASDH with cerebral contusion. The clinical outcome with the old therapeutic strategy was good recovery (GR) in 7 cases, moderate disability (MD) in 5, severe disability (SD) in 2, vegetative state (PVS) in 3 and death (D) in 10, whereas the outcome with the new strategy resulted in GR in 15 cases, MD in 3, D in 2. These clinical results indicate that the rates of mortality and severe morbidity were markedly reduced with our new therapeutic strategy.
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PMID:[Wide craniotomy-small dural incisions and intentionally delayed removal of intracerebral contusional hemorrhage for acute subdural hematoma]. 943 Jan 42