Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

3,5-Dinitrobenzoic acid hydrazide (1) treated with substituted phenyl isothiocyanates (2a-2d) in dry benzene yields N'-aryl-N4-(3,5-dinitrophenyl) thiosemicarbazides (3-6), which cyclizes in NaOH solution yielding 1-aryl-5-(3,5-dinitrophenyl)-2-mercapto-1,3,4-triazoles (7-10). The reaction of the appropriate 7-10 respectively with chloroacetic acid and 4-chlorobenzoic acid in NaOH solution gave 1-aryl-5-(3.5-dinitrophenyl)-2-mercapto methyl/phenyl carboxy-1,3,4-triazoles (11-18). All the compounds were found to be relatively non toxic (ALD greater than 1000 mg/kg), whereas in their gross CNS observations the compounds were found to be psychotropic. They increased or decreased spontaneous locomotor activity and at high doses produced writhing and mild hypothermia. Some of them mildly affected the cardiovascular system and showed antiinflammatory activity.
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PMID:Synthesis and pharmacological screening of some new triazoles. 324 71