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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The Topical Cooling Device(R)(*) (TCD) is a closed system that circulates sterile saline solution at 4 degrees C in the pericardium. The system's ability to maintain cardiac hypothermia under clinical conditions depends on the method of cannulation and the core temperature of the patient. After studies were done in ten groups of patients, with at least three patients in each group, the effects of these two variables on TCD performance were then observed in a series of over 250 coronary artery bypass cases and are summarized in the following report.
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PMID:The topical myocardial cooling device: Correlation of its effectiveness with method of cannulation and core temperature of the patient. 1521 97

Despite improvements in obstetrical and neonatal care, and introduction of hypothermia as a neuroprotective therapy, perinatal brain injury remains a frequent cause of cerebral palsy, mental retardation and epilepsy. The recognition of dysfunction of cerebral autoregulation is essential for a real time measure of efficacy to identify those who are at highest risk for brain injury. This article will focus on the "neurovascular unit" approach to the care of asphyxiated neonates and will address 1) potential mechanisms of dysfunctional cerebral blood flow (CBF) regulation, 2) optimal monitoring methodology such as NIRS (near infrared spectroscopy), and TCD (transcutaneous Doppler), and 3) clinical implications of monitoring in the neonatal intensive care setting in asphyxiated newborns undergoing hypothermia and rewarming. Critical knowledge of the functional regulation of the neurovascular unit may lead to improved ability to predict outcomes in real time during hypothermia, as well as differentiate non-responders who might benefit from additional therapies.
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PMID:The "neurovascular unit approach" to evaluate mechanisms of dysfunctional autoregulation in asphyxiated newborns in the era of hypothermia therapy. 2506 4