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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Various peptide hormones appear to exert behavioral and pharmacologic effects apart from their classical endocrine actions. Thytrotopin-releasing hormone (TRH), for example, antagonizes the sedation and hypothermia produced by barbiturate and other depressant drugs and de Wied has shown that ACTH 4-10, TRH, LHRH and certain related substances show some activity in inhibition of extinction of a pole-jumping avoidance response in the rat. These data provided the impetus for screening ACTH 4-10, LHRH, and related peptides for analeptic activity. ACTH 4-10 and ACTH 4-7 were inactive in antagonizing pentobarbital whether administered peripherally or centrally. ACTH 4-7 amide and 4-Met(O2), 8-D-Lys,9-Phe-ACTH 4-9 were active regardless of route of administration LHRH and two tripeptide fragments (pGlu-His-Trp-NH, and pGlu-His-Phe-NH2) showed analeptic activity only after intracisternal administration. Thus, some peptide fragments related to ACTH 4-10 and LHRH were shown to share to some degree the analeptic properties previously demonstrated for TRH.
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PMID:Comparison of the analeptic potency of TRH, ACTH 4-10, LHRH, and related peptides. 18 24

The antinociceptive and hypothermic effects of intracisternal administration of 11 endogenous neuropeptides and morphine were evaluated in mice. Of the substances tested, only neurotensin (NT) and beta-endorphin exerted significant antinociceptive and hypothermic effects; NT was the most potent in inducing hypothermia whereas beta-endorphin was the most potent antinociceptive agent via this route of administration. Both NT, and beta-endorphin were, on a molar basis, considerably more potent antinociceptive agents than morphine, [Met]enkephalin, or [Leu]enkephalin. NT-induced analgesia and hypothermia both were significantly dose-dependent. Substance P was found to produce significant hyperalgesia and hyperthermia. Bombesin produced a significant hypothermic effect, whereas somatostatin and luteinizing hormone-releasing hormone (luliberin) produced hyperthermia. None of the other peptides studies [bradykinin, thyrotropin-releasing factor (thyroliberin), melanocyte-stimulating hormone release-inhibiting factor (melanostatin), somatostatin, [Met]enkephalin, and [Leu]enkephalin] produced any significant alterations in colonic temperature or response to a noxious stimulus with the doses tested. These data demonstrate that NT and beta-endorphin, two endogenous brain peptides, are potent in inducing hypothermia and in producing an antinociceptive state.
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PMID:Alterations in nociception and body temperature after intracisternal administration of neurotensin, beta-endorphin, other endogenous peptides, and morphine. 29 52

L-Methionine-D,L-sulfoximine (MSO), intraperitoneally (i.p.) or intracerebroventricularly (i.c.v.) (third ventricle) injected at a convulsant dose, induced a centrally mediated body hypothermia in the restrained rat maintained at an ambient temperature of 23 degrees C. Pretreatment with (+/-)-pindolol (1.5-3 mg/kg s.c.) significantly attenuated MSO-induced hypothermia, but at a dose of 6 mg/kg s.c. hypothermia developed without any modification of its characteristics. Pretreatment with (-)-propranolol (16-25 mg/kg i.p.) potentiated MSO-induced hypothermia, but pretreatment of MSO-treated rats with ketanserin (0.7-4 mg/kg i.p.) did not significantly modify hypothermia. Selective antagonists for beta-adrenoceptors were used and their effects on MSO-induced hypothermia were compared with those of pindolol and propranolol. Pretreatment with betaxolol (1.5-4 mg/kg s.c.) did not modify the hypothermia following administration of MSO, but potentiation of hypothermia was recorded in rats pretreated with ICI 118,551 (2.26 mg/kg i.p.) then i.p. injected with MSO. These findings favour a control exerted by 5-HT1 receptors in the central development of MSO-induced hypothermia in the restrained rat.
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PMID:Involvement of serotonin receptors in methionine sulfoximine-induced hypothermia in the rat. 135 3

L-Methionine-D,L-sulfoximine (MSO) intraperitoneally or intracerebroventricularly (third ventricle) injected at convulsant doses induced a hypothermia, primarily associated with a syndrome of ataxia, in the restrained rat maintained at an ambient temperature of 23 degrees C. Depletion of brain serotonin (5-HT) by pretreatment with p-chlorophenylalanine (PCPA), p-chloroamphetamine (PCA), and d-fenfluramine (FFA) did not significantly modify the time course and magnitude of MSO-induced developing hypothermia but it enhanced abnormal motor behavior. Enhancement of 5-HT synthesis in MSO-submitted rats pretreated with 5-hydroxytryptophan (5-HTP) (200 mg/kg, IP) alone or 5-HTP (100 mg/kg, IP) preassociated with carbidopa (10 mg/kg, IP) suppressed significantly hypothermia, but it did not greatly modify motor disturbances. In conclusion, the neurocytochemical processes initiating hypothermia following administration of MSO to the rat appear to be linked to a slowdown of the rate of brain 5-HT turnover, maybe at the level of the midbrain raphe nuclei.
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PMID:Possible link between brain serotonin metabolism and methionine sulfoximine-induced hypothermia and associated behavior in the rat. 140 1

With the combination of a noninvasive saturation measurement and plethysmography, pulse oximetry has become an important monitoring method for peripheral perfusion and oxygen supply. Indications for pulse oximetry is practically every anaesthesia especially in geriatric patients and patients with one-lung-anaesthesia, obesity, asthma and emphysema. Pulse oximetry has proved its worth in the transport of emergency patients. Sources of error are a bad perfusion at the site of measurement (hypotension, hypothermia), dyshaemoglobinaemia (Met-carboxy-haemoglobin) and interference of colours (dark skin, intravenous colours, high light intensity). Accuracy of response of most currently available pulse oximeters lies between 2-3% (SD) with oxygen saturations between 80-100%. Deviations increase at lower oxygen saturations. Pulse oximetry will soon be regarded as minimal monitoring standard worldwide together with the ECG, blood pressure, pulse and respiratory monitoring.
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PMID:[The importance of pulse oximetry for anesthesia]. 204 38

The effects of sublethal doses of selenite, selenate, selenocystine (Se-Cys) and selenomethionine (Se-Met) as well as of tellurite on body temperature and feeding behavior were examined in male ICR mice. Ten or 30 mumol/kg of chemicals were injected subcutaneously and body temperature was measured up to 4 h. In a separate experiment, the gastric content was weighted 4 h after injection. All chemicals except Se-Met induced both hypothermia and hyperphagia, suggesting that: (a) these two effects are related to each other; (b) among the chemicals tested, Se-Cys appears to be the most potent hypothermia inducer; (c) Se-Met is unique in that it has neither effect.
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PMID:Transient hypothermia and hyperphagia induced by selenium and tellurium compounds in mice. 230 49

It has been suggested that a nonapeptide called V-9-M (Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met) is produced by the processing of procholecystokinin. However, its physiological and pharmacological activities are not known. In the present study, synthetic V-9-M amide was injected into the lateral ventricle of the rat and its effects on general activities were observed. V-9-M caused a marked sedation; it suppressed spontaneous activity and hypermotility induced by thyrotropin-releasing hormone, methamphetamine, and apomorphine. Hypomotility induced by small doses of apomorphine was also decreased further. V-9-M caused hypothermia and prolonged the duration of pentobarbital-induced sleep, and it decreased locomotion in an open-field situation. However, V-9-M did not affect appetite in fasted rats.
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PMID:Neuropharmacological properties of V-9-M, a putative neuropeptide derived from procholecystokinin, in the rat. 250 Oct 13

The effect of hypoxia, cold and hypoxic-cold stress was studied on plasma and brain amino acid levels of rats. Hypoxia caused a considerable increase in plasma taurine and phosphoserine levels, while the remaining amino acids (except valine, cystine, iso-leucine, leucine and anserine) decreased significantly. On the other hand cold stress significantly increased the plasma taurine, asparagine and decreased glutamine, glycine, alanine, methionine and histidine levels. The hypoxic-cold stress combination produced marked decrease in most of the plasma levels of amino acids (except phosphoserine, taurine and anserine). During brain amino acid studies, hypoxia significantly elevated taurine, aspartic acid, valine and leucine levels while the concentrations of other amino acids were not significantly altered. Cold stress was found to elevate taurine and valine levels, while leucine and phenyl-alanine levels were significantly decreased. Exposure of animals to hypoxic-hypothermia affected significantly the brain levels of valine, methionine, leucine and arginine. Since, the change in amino acid levels in brain is less prominent, as compared with plasma, in response to stress, it appeared that brain possesses higher adaptive mechanisms to counteract the stress induced amino acid level imbalance.
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PMID:Effect of hypoxia and/or cold stress on plasma and brain amino acids in rat. 274 Jun 20

L-Methionine sulfoximine (MSO) intraperitoneally injected at subconvulsive and convulsive doses induced a rectal hypothermia in the restrained rat maintained at an ambient temperature of 23 degrees C; this hypothermia developed during the preconvulsive period, and it was not suppressed by simultaneous injection of L-methionine which antagonized the behavioral effects of ammonia elevated contents in the central nervous system. The development of rectal hypothermia was faster when the injection of MSO was made into the lateral cerebral ventricle and particularly into the third ventricle. MSO-induced hypothermia seemed to be a poikilothermia-like state in the cold environment with retention of a normal regulation in the heat environment. Infusion of MSO into the anterior hypothalamic/preoptic (AH/PO) area induced a rapid rectal hyperthermia, but infused into the mammillary region MSO had no effect on rectal temperature. It is suggested that rectal hypothermia induced by MSO may be directly related to a depressive effect on glucose oxidative metabolism in cell structures, maybe astroglial cells, located in the vicinity of the ventricle or the capillary walls.
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PMID:Study of the hypothermia induced by methionine sulfoximine in the rat. 325 71

Accumulated evidence suggests that increased endogenous opioid activities may facilitate the onset of hibernation. The present study investigated the change in thermoregulatory responses following ICV infusion of morphine or [D-Ala2]-Met enkephalinamide (EK) in unanesthetized, unrestrained Columbian ground squirrels (Spermophilus columbianus) during its annual hibernation cycle. In the nonhibernating phase, low doses of either morphine (less than 160 micrograms) or EK (less than 400 micrograms) elicited a dose-related hyperthermia and an increase in heat production, whereas a higher dose of opiates caused hypothermia and a decrease in metabolic rate. Naloxone (5 mg/kg, SC) pretreatment reduced or reversed both the hyper- and hypothermic responses to opiates. Lower ambient temperature (5 degrees C) enhanced the hypothermic response and attenuated the hyperthermic response. In the hibernating phase, euthermic ground squirrels exhibited a reduced responsiveness to exogenous opiates: the hyperthermic response to low dose of morphine (10 micrograms) was significantly reduced and hyperthermia, rather than hypothermia was observed at the highest dose of morphine (160 micrograms). The reduced responsiveness to opiates observed during the hibernating phase seems to suggest a reduction in opiate receptor efficacy which is in agreement with the contention that an increase in endogenous opioid activities may be incumbent with the commencement of hibernation.
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PMID:Seasonal difference in thermoregulatory responses to opiates in a mammalian hibernator. 357 72


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