Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rubratoxin B, a metabolite of Penicillium rubrum, is a potent mycotoxin that produces hepatic mid-zonal necrosis. Using propylene glycol as the solvent, the acute LD50 (i.p.) in male mice was estimated at 1.42 mg/kg. Pretreatment with s.c. pellets of pentobarbital reduced this toxicity approximately 42 percent, while castration and SKF 525A pretreatment enhanced toxicity approximately 20 percent and 60 percent, respectively. These studies also demonstrated that rubratoxin B potentiated pentobarbital-induced narcosis and enhanced pentobarbital hypothermia. The effect of SKF-525A and pentobarbital on the LD50 value of rubratoxin B suggests that the toxicity of this mycotoxin in mice does not arise from a toxic metabolite but from the parent compound.
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PMID:Interaction of rubratoxin B and pentobarbital in mice. 58 97

1. Mestranol (oestrogen) prolonged, whilst lynestrenol (progestin) reduced, the duration of pentobarbitone and hexobarbitone sleep in mice, whilst the effects of barbitone were not altered.2. The effects of these steroids on pentobarbitone sleep were dose-related, did not show tachyphylaxis, and produced optimal effects after only 4 days pretreatment.3. The effects of lynestrenol were abolished by SKF 525A, whilst those of mestranol were markedly potentiated, suggesting a different mechanism and/or locus of action for mestranol and SKF 525A.4. Examination of plasma levels of pentobarbitone in mice pretreated with mestranol, lynestrenol or SKF 525A showed that lynestrenol increased whilst mestranol and SKF 525A reduced the rate of clearance of barbiturate from the plasma.5. The effects of lynestrenol disappeared when pentobarbitone was prevented from inducing hypothermia, whilst some significant prolongation of pentobarbitone sleep persisted in mestranol treated mice. This suggested that the ability to potentiate hypothermia was not the sole mechanism by which the effects of pentobarbitone were enhanced by mestranol.6. It is concluded these steroids alter the duration of action of pentobarbitone (and hexobarbitone) by changing the rate of barbiturate metabolism. In the case of mestranol, this might be a combination of an effect upon basal metabolic rate (enhancing hypothermia) and a direct effect on the liver. An effect upon renal clearance cannot be excluded by these results.
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PMID:The effects of oestrogens and progestins on the response of mice to barbiturates. 536 Mar 38

Three pharmacological techniques for measuring inhibition of "non-specific" oxidase activity in the mouse are described: (1) potentiation of pentobarbitone hypnosis, (2) potentiation of chlorpromazine hypothermia; and (3) reduction in the toxicity of octamethylpyrophosphorodiamide (schradan). Iproniazid, isoniazid, and beta-diethylaminoethyl 3,3-diphenylpropylacetate (SKF 525A) gave comparable results in all three tests.
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PMID:Pharmacological methods of estimating inhibition of drug oxidation in the mouse. 1366 84