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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of parenterally injected pargyline and tryptophan on rectal temperature and behavior have been studied in male and female rats. Pargyline alone (50 mg/kg) produced hypothermia in both sexes. Pargyline (50 mg/kg) followed by low doses (20--50 mg/kg) of tryptophan caused a behavioral syndrome consisting of tremor, hindlimb abduction, forepaw treading, and straub tail. In females, but not in males, hypothermia was potentiated. The same dose of pargyline followed by higher doses (60--150 mg/kg) of tryptophan produced a short hypothermia followed by a dose-dependent behavioral syndrome, hyperthermia, and mortality. On all of these measures, females responded following shorter latencies and lower doses of tryptophan. Both hypothermia and hyperthermia were observed in treated animals following pretreatment with a peripheral decarboxylase inhibitor. The results suggest a complex role for serotonin in thermoregulation. The sex differences observed suggest higher activity of serotonin in female rat brains following the drug treatment, which may be accounted for by a higher utilization rate of tryptophan.
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PMID:Sex differences in behavioral and thermal responses to pargyline and tryptophan. 10 23

Cocaine injected intraperitoneally into rats resulted in a dose-dependent hypothermia. Intracerebral injection of smaller doses also produced a fall in body temperature. In rabbits and guinea-pigs, cocaine produced hyperthermia, in mice and chicks it produced hypothermia while inconsistent changes were produced in goats. Pre-treatment of rats with 6-hydroxydopamine, alpha-methyl-m-tyrosine or haloperidol significantly antagonized the cocaine hypothermia. Pre-treatment of the rats with either hyoscine or methscopolamine resulted in some but non-significant attenuation of the cocaineinduced hypothermia. Pre-treatment with p-chlorophenylalanine, however, did not modify the cocaine hypothermia. Pargyline pre-treatment significantly antagonized the hypothermic action of cocaine. It is suggested that cocaine may cause the release of noradrenaline centrally or it may potentiate its action by interfering with the uptake mechanism. It is also possible that cocaine may have a direct effect on the heat regulating centre in the hypothalamus.
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PMID:Hypothermic effect of cocaine in rats. 13 13

1. In mice 1-10 mug histamine injected intraventricularly produces hypothermia.2. This hypothermia was not antagonized by chlorcyclizine administered subcutaneously or intraventricularly, but chlorcyclizine injected intraventricularly was effective in antagonizing the hypothermia produced by a subcutaneous injection of histamine.3. Pretreatment with atropine was without effect on the hypothermia produced by an intraventricular injection of 10 mug histamine.4. Amphetamine and tranylcypromine not only effectively reduced the intensity of, or abolished, the hypothermia but also reversed the response to an intraventricular injection of 10 mug histamine so that hyperthermia was produced. Pargyline was without effect.5. Tolazoline strongly potentiated the hypothermia produced by the intraventricular injection of 10 mug histamine, but phentolamine did not.6. It is concluded that at least part of the hypothermia produced by a subcutaneous injection of histamine arises as a result of an action on the central nervous system.7. The possible mechanisms by which histamine acting on the central nervous system produces hypothermia and the suggestion that histamine may have a physiological role in thermoregulation are discussed in the light of these findings.
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PMID:Hypothermia produced in mice by histamine acting on the central nervous system. 439 42