Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The on-going high mortality from sepsis motivates continuous research for novel therapeutic strategies. Neuropeptide Y (NPY), a sympathetic neurotransmitter, has been shown to increase survival in experimental septic shock in rats. This protective effect might be due to immunological, cardiovascular or thermoregulatory effects. The aim of this study was to examine the in vivo effect of peripherally administered NPY on body temperature, blood pressure and heart rate in endotoxaemic animals. In order to obtain clinically relevant data, various physiological parameters were monitored in parallel via radio-telemetry in chronically intravenously cannulated, freely behaving rats. Rats received a sublethal bolus of lipopolysaccharide (LPS, 100 microg kg(-1) I.V.) and the three parameters were continuously recorded for 72 h. Endotoxaemic rats showed a long-lasting hypotension, an initial hypothermia (-0.5 degrees C), followed by a prolonged febrile phase (+1.6 degrees C 6 h after endotoxin challenge) associated with a decrease of the circadian rhythm amplitude of temperature. Pretreatment with NPY (160 pmol kg(-1) I.V. over 75 min) prevented hypotension and significantly stabilized body temperature immediately following the application. The febrile phase was effectively reduced for at least 72 h. These telemetrically obtained findings clearly demonstrate that pretreatment with NPY positively influences two life-threatening symptoms in endotoxaemia and might be a future option for a successful clinical treatment regimen.
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PMID:Neuropeptide Y stabilizes body temperature and prevents hypotension in endotoxaemic rats. 1538 81

1. Based on records of all (n = 59 171 843) broiler chickens slaughtered over three years at one processing plant, the overall mortality of birds in transit was 0.126%. 2. There was a pronounced seasonal effect with increased mortality in the summer months, particularly June, July and August. Mortality increased when the maximum daily temperature (measured in the shade) rose above about 17 degrees C at the start of the summer. 3. Between 17.0 and 19.9 degrees C, mortality was 30% higher than at lower temperatures. Between 20.0 and 22.9 degrees C it increased 2.6-fold, and at temperatures of above 23 degrees C 6.6-fold. There was no evidence of birds dying from hypothermia at very low ambient temperatures (down to -1 degrees C). 4. The implication from the results is that above a maximum daily temperature of 17 degrees C steps may need to be taken to ameliorate the damaging effects of transport on bird welfare.
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PMID:Relationship between maximum daily temperature and mortality of broiler chickens during transport and lairage. 1642 5