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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The clinical results with cardioplegic solutions and hypothermia during aortic cross-clamping are compared with the clinical results obtained with hypothermia only. To complete the study miocardial biopsies were obtained during aortic cross-clamping in order to evaluate the concentration of ATP and CPK. The obtained data confirm the effectiveness of the myocardial protection.
G Ital Cardiol 1979
PMID:[Myocardial protection from cardioplegic and hypothermia during aortic cross-clamping (author's ttrans)]. 45 88

Local hypothermia as a procedure for myocardial protection was utilized in 50 patients; 17 had congenital and 33 aquired heart disease. On patient with diagnosis of A-V canal, previously operated on, died on the 2nd postoperative day after mitral valve replacement and closure of a residual defect. Two other valvular patients died suddenly on the 9th and 20th postoperative days from thrombosis of the prosthesis. The lengths of time of aortic clamping required for correction of these various cardiopathies were analized and correlated with the final results. In comparison with the experience of other authors, a close relationship between the duration of the myocardial ischemia and the figures of morbi-mortality was observed. It is concluded that local hypothermia constitutes an adequate procedure for myocardial protection on the condition that the length of aortic clamping times do not exceed certain limits.
Arch Inst Cardiol Mex
PMID:[Protection of the myocardium with local hypothermia in open heart surgery]. 55 36

The experimental behaviour of a new semiprosthesis for mitral and tricuspid ring plasty is studied. The tolerance of the materials of which the ring is composed was realized by inserting it into the right atrium with hypothermia and occlusion of the cavas, in dogs which were permitted to live 6 months. It was shown that the ring was covered by a very thin, white membrane, with uniform characteristics and strongly attached. The histologic and the ultrastructural study with the electronic microscope, showed proliferation of conjunctive tissue with abundant collaginous fibers. The free border of this covering presented endotheliazation with flat endothelial cells. The prosthetic material behaves as an inert body when there is no evidence of lymphocytes or polymorfonuclears.
Arch Inst Cardiol Mex
PMID:[Experimental study of a new circular semiprosthesis for mitral and tricuspid valve replacement]. 61 Jun 40

In 63 patients with either acute transmural or nontransmural myocardial infarction, the Q-T interval was prolonged beyond normal limits on at least 1 of the 5 days after infarction in 27 patients (8 with transmural and 19 with nontransmural infarction). The time-related changes in the corrected Q-T (Q-Tc) interval were defined for the entire sample and showed significant expansion, maximal on day 2, from a preinfarction control value. By day 5, the Q-Tc interval was no longer significantly prolonged and was not expanded beyond normal limits in any patient. Various possible causes of Q-T prolongation in myocardial infarction are local hypothermia, local conduction delay, neurogenic effect and local hypocalcemia. Collateral evidence suggests that the letter may contribute significantly to prolongation.
Am J Cardiol 1978 Apr
PMID:Time-related changes in the Q-T interval in acute myocardial infarction: possible relation to local hypocalcemia. 64 72

Twenty-seven consecutive patients less than 2 years of age underwent primary intracardiac repair of complete atrioventricular (A-V) canal. Three (19 percent) of the 16 operated on after January 1, 1975 died in the hospital, a smaller proportion than the 8 of 11 patients who died in the hospital after operation between 1972 and 1975 (P = 0.005). The date of operation as a continuous variable is also related to the probability of hospital death (P = 0.016). Age at operation was not related to hospital mortality among the total group of 27 infants, nor were the anatomic characteristics of the anterior and posterior bridging leaflets, the location and size of the interventricular communications or the duration or technique of profound hypothermia (total circulatory arrest versus low perfusion flow rate). The improved results in the 16 patients operated on since January 1, 1975 are believed to be primarily the result of an improved ability to construct "mitral" and "tricuspid" valves from the common A-V valve. Fourteen of the 16 hospital survivors are alive and well 5 to 60 months after operation. These results and the natural history of patients with this malformation indicate that there should be no change in the policy of performing elective intracardiac repair before age 2 years and primary repair rather than pulmonary arterial banding when operation is required in the early months of life.
Am J Cardiol 1978 May 01
PMID:Primary repair of complete atrioventricular canal in patients less than 2 years old. 64

This study examined the pathophysiology of the myocaridal damage produced by direct current shock over a dose range of 10 to 90 watt-seconds, applied directly to the heart in 26 dosgs. The extent of injury produced was assessed with creatine kinase depletion and light and electron microscopy, and was correlated with in vivo imaging and tissue distributions of the isotopes technetium-99m pyrophosphate and thallium-201. Changes in intramyocardial temperature and regional myocardial blood flow were also measured. Uptake of technetium-99m pyrophosphate occurred exponentially with graded increases in shocks, and this agent was more sensitive than thallium-201 in detecting injury both on imaging and at tissue level. The threshold for significant injury was approximately 30 watt-seconds, and on electron microscopy a characteristic feature was marked dehiscence of the intercalated disks between the damaged myocytes. The use of different-size paddles did not appear to affect the total number of cells damaged. However, with large paddles the injury was more superficial and spread over a wider area. With short time intervals between successive shocks, a greater amount of injury occurred, in part because of a compounding of the thermal component of the damage. Hypothermia can reduce the degree of injury.
Am J Cardiol 1979 Feb
PMID:Cardiac damage produced by direct current countershock applied to the heart. 76 Apr 77

An 8 week old infant with severe heart failure from type 1 truncus arteriosus underwent successful corrective surgery employing the Rastelli procedure with use of deep hypothermia and total circulatory arrest. Postoperative hemodynamic studies showed complete closure of the septal defect, disappearance of truncal stenosis, but presence of mild porcine valve stenosis. This procedure is possible even in very small subjects and is preferable to palliative pulmonary arterial banding.
Am J Cardiol 1976 Jul
PMID:Surgical correction of truncus arteriosus in infancy. 93 84

The fine structure and the content in energy-rich phosphate compounds, glycogen, and metabolites of the Embden-Meyerhoff-pathway in rabbits hearts or human papillary muscles arrested by magnesium aspartate-procaine are investigated in normothermia and mild or deep hypothermia. In all experimental conditions the break-down of adenine nucleotides and glycogen was distinctly retarded in cardioplegia compared to ischaemic arrest. While e.g. an ATP-content of 3.6 mumole/g wet weight was found after 40 min. at 32 degrees C in the magnesium asparate-procaine arrested heart, it dropped down to 1.3 mumole/g in the ischaemically arrested heart. In cardioplegia after 60 min at 15 degrees C the in vivo contents of ATP and glycogen were determined. The rate in metabolic changes in the magnesium aspartate-procaine arrested human papillary muscle was in the range of that recorded in the arrested rabbit heart. The ultrastructural appearance of the cardioplegically arrested heart did not differ from that of the controls after 20 min at 32 degrees C or 120 min at 15 degrees C. In hearts arrested by cardioplegia 40 min at 32 degrees C first signs of ischaemic lesions e.g. mild swelling of mitochondria and few rarefications in mitochondrial matrix were observed. Because of the significantly improved preservation of the fine structure of the heart and retardation of ischaemically provoked changes in cardiac metabolism, the method of inducing heart arrest by cardioplegia should also clinically be given preference to methods of arresting the heart by ischaemia.
Basic Res Cardiol
PMID:Metabolism and structure of the magnesium aspartate-procaine-arrested ischaemic heart of rabbit and man. 94 73

A 16 day old 2.5 kg premature infant with total anomalous pulmonary venous drainage to the coronary sinus was successfully treated with use of profound hypothermia and total circulatory arrest. To the best of our knowledge, this neonate is the smallest to successfully undergo correction of this anomaly. A plea is made for a more aggressive approach in early recognition and assessment of these critically ill infants, followed by early surgical correction.
Am J Cardiol 1976 Jan
PMID:Successful correction of total anomalous pulmonary venous connection in a 2.5 kilogram premature neonate. 124 27

The effects of plain ischemia (34 degrees C) and the protective role of hypothermia (20 degrees C) alone or in combination with cardioplegia (St Thomas' Hospital [STH] or glucose-potassium-nifedipine [GPN]) on the intracellular kinetics of the activator calcium of cardiac muscle were quantified and compared from the interval-force behaviour (mechanical restitution) of right and left ventricles of the perfused rat heart. Plain ischemia caused a major depression in the restitution of force of contraction of both ventricles, deranged the mixed linear-exponential functions by significantly increasing the time constants of the fitted mechanical restitution curves (MRC) and altered the control right/left ventricle interval-force relationship. The right ventricle was found to be more susceptible to ischemic damage than the left ventricle, and its inotropic reserve was virtually abolished by 1 h of plain ischemia. Hypothermic preservation during ischemia improved the mechanical restitution, salvaged the inotropic reserve and optimized right/left ventricle interval-force relationship, but the time constants of the fitted MRCs were still prolonged. However, both the cardioplegic formulations were equally effective in normalizing the time constants of the fitted curves. In general, right ventricle functions were better preserved by STH cardioplegia and left ventricle functions were better preserved by GPN cardioplegia. Cardioplegic interventions did not further improve the ventricular inotropic reserve compared with hypothermic preservation. Additional beneficial effects of cardioplegic formulations were directed towards stabilizing the linear-exponential functions and hence restitution of force of contraction.(ABSTRACT TRUNCATED AT 250 WORDS)
Can J Cardiol 1992 May
PMID:Intracellular kinetics of the activator calcium of rat heart after ischemic arrest and cardioplegia: quantitative comparison of right and left ventricles. 137 92


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