Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
Compound
Query: UMLS:C0020672 (
hypothermia
)
17,327
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2,1, 3-benzothiadiazole] on core temperature in the mouse was investigated in comparison with that of clonidine.
Tizanidine
decreased core temperature in unanaesthetized, freely-moving normal mice. Clonidine produced
hypothermia
in normal mice. The alpha 2-antagonist yohimbine produced an antagonism to tizanidine- and clonidine-induced
hypothermia
, while naloxone failed to antagonize the
hypothermia
. It is concluded that tizanidine and clonidine produce a similar hypothermic effect via an alpha 2-adrenoreceptor, but not an endogenous opioid system.
...
PMID:Effect of tizanidine on body temperature in the mouse. 371 1
