Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

2-Deoxy-D-glucose (2-DG), insulin, or norepinephrine (NE), when injected into the cerebral ventricles of conscious mice, produce decreased rates of O2 consumption and hypothermia. These changes are accompanied by hyperglycemia with 2-DG, hypoglycemia with insulin, and normoglycemia with NE. Desipramine blocks the reduction in body temperature and O2 consumption produced by each of these agents, but does not modify significantly their effects on plasma glucose. The latter suggests that the thermal and oxidative responses to central glucopenia can be dissociated from concurrent alterations in circulating glucose. Propranolol enhances the hypothermic response produced by administered 2-DG, insulin, or NE. Phentolamine, however, antagonizes the hypothermia only with NE, indicating the 2-DG and insulin are probably not acting through the release of endogenous NE.
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PMID:Drug modification of hypothermia induced by CNS glucopenia in the mouse. 98 1

2-Deoxy-D-glucose (2-DG) elicits significant and prolonged hypothermia in a variety of animals when administered either peripherally or centrally. From our current studies it would appear that, in high concentrations (250 mg/kg or more, ip), 2-DG can act directly on peripheral tissues in the rat by competitively interfering with glucose metabolism and consequently with normal heat producing mechanisms. When a low concentration of 2-DG (20 micrograms) is injected centrally, the ensuing glucopenia results in vagal stimulation and subsequent diminution of peripheral heat production. Vagal involvement is concluded from studies with atropine, which demonstrated total inhibition of the usual 2-DG depression of body temperature by administration to the ventral premammillary nucleus (PMV), a site that is normally extremely sensitive to this analog of glucose. Additionally, from studies with PMV-lesioned rats, it was concluded that an intact nucleus is necessary for thermoregulation in a normal, a hot, or a cold environment.
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PMID:2-Deoxy-D-glucose-induced hypothermia: thermoregulatory pathways in rat. 743 98