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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cooling of rats down to the rectal temperature of 33--35 degrees without the use of narcotic and neuroplegic drugs did not cause distinct alterations in activity of the oxidative enzymes of tricarboxylic acid cycle--isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, malate-, succinate- and pyruvate dehydrogenases in brain tissue. At the same time, inhibition of the activity of these dehydrogenases occurred in profound hypothermia (cooling to 19--20 degrees). In this case the activity of succinate dehydrogenase was decreased less distinctly as compared with the activity of NAD-dependent dehydrogenases. Succinic acid appears to be an especially important substrate for oxidation in brain of the chilled rats.
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PMID:[Activity of Krebs cycle oxidative enzymes in the brain in hypothermia]. 45 97

During short-lasting hypothermia in rats the activity of isocitrate dehydrogenase (E.C.1.1.1.42) and malic dehydrogenase (E.C.1.1.1.37) was determined in the mitochondrial fraction of liver cells, myocardial cells and skeletal muscle fibres of the femoral muscle and no statistically significant differences were found between the obtained values and those in a control group. On the other hand, the activity of glucose-6-phosphate dehydrogenase (E.C.1.1.1.49) in the cytoplasmic fraction of these tissues was decreased in the hypothermic rats by 46% in the liver, by 50% in the myocardium and by 59% in the skeletal muscle of the thigh. A possible cause of this reduced activity of this enzyme in hypothermia could be changes in the structure of the enzymatic protein, deficiency of the hormone activating the enzyme, that is insulin, and/or inhibition of the pentose-phosphate cycle by fatty acids released in excess.
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PMID:Activity of certain enzymes in the mitochondrial and cytoplasmic fractions of liver cells, myocardium and skeletal muscle of the rat during short-lasting hypothermia. 718 57

This paper describes the cardiorespiratory variables and the incidence of anaesthetic complications in dogs. For this, a retrospective study of 1281 anaesthesias was performed. Heart rate (HR), non-invasive mean arterial (MAP), systolic (SP) and diastolic pressures (DP), invasive mean arterial (IMAP), systolic (ISP) and diastolic pressures (IDP), central venous pressure (CVP), respiratory rate (RR), tidal volume (V(T)), minute volume (V(M)), end-tidal CO(2) (EtCO(2)), arterial oxygen saturation (SpO(2)), temperature (T) and death are reported. Data were described both globally and separately for each ASA (American Society of Anaesthesiologists classification) status. An ANOVA and a Tukey's test were used for comparing the different ASA status' values (alpha=0.05). During anaesthetic maintenance, the mean +/- SD of the studied variables were: HR: 91+/-27 bpm. MAP: 86+/-24 mmHg. IMAP: 80+/-22 mmHg. SP: 114+/-25 mmHg. ISP: 109+/-26 mmHg. DP: 67+/-23 mmHg. IDP: 66+/-22 mmHg. CVP: 5+/-3 mmHg. RR: 19+/-11 rpm. V(T): 14+/-7 ml/kg. V(M): 191+/-93 ml/kg/min. EtCO(2): 40+/-8 mmHg. T: 37.1+/-1.7 degrees C. ASA III and ASA IV patients, compared with those with ASA I, showed higher values of HR, RR, V(T) and V(M) and lower in IMAP, CVP, EtCO(2), SpO(2) and T. The most frequent complications were bradycardia (36.3% of the patients), hypotension (37.9%), hypoventilation (63.4%), hypoxia (16.4%), hypothermia (4.8%) and death (0.9%). Cardiorespiratory complications frequently occur in dogs during general anaesthesia.
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PMID:Normal values and incidence of cardiorespiratory complications in dogs during general anaesthesia. A review of 1281 cases. 1793 Dec 19