Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0020672 (hypothermia)
 17,327 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During short-lasting hypothermia in rats the activity of isocitrate dehydrogenase (E.C.1.1.1.42) and malic dehydrogenase (E.C.1.1.1.37) was determined in the mitochondrial fraction of liver cells, myocardial cells and skeletal muscle fibres of the femoral muscle and no statistically significant differences were found between the obtained values and those in a control group. On the other hand, the activity of glucose-6-phosphate dehydrogenase (E.C.1.1.1.49) in the cytoplasmic fraction of these tissues was decreased in the hypothermic rats by 46% in the liver, by 50% in the myocardium and by 59% in the skeletal muscle of the thigh. A possible cause of this reduced activity of this enzyme in hypothermia could be changes in the structure of the enzymatic protein, deficiency of the hormone activating the enzyme, that is insulin, and/or inhibition of the pentose-phosphate cycle by fatty acids released in excess.
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PMID:Activity of certain enzymes in the mitochondrial and cytoplasmic fractions of liver cells, myocardium and skeletal muscle of the rat during short-lasting hypothermia. 718 57

We examined whether vascular endothelial function is impaired with deep hypothermia during cardiopulmonary bypass. Such impairment may cause the prolonged hypoperfusion of tissues or organs. Thirty adult patients were classified into three groups according to the degree of hypothermia during cardiopulmonary bypass; deep (DH: 18-20 degrees C, n = 10), moderate (MDH: 25-30 degrees C, n = 10) and mild (MLH: 32-34 degrees C, n = 10) hypothermia. A bolus dose of 100 mg acetylcholine was injected, followed by 1 mg nitroglycerine 20 min later under hypothermic cardiopulmonary bypass. Plasma concentrations of nitric oxide metabolites (NOx) and endothelin-1 were determined until the 7th post-operative day (POD). The reduction of arterial pressure after acetylcholine was the smallest in the DH group (-9 +/- 6 mmHg, p < 0.01). The time to reach the maximum reduction of arterial pressure was the longest in the DH group (acetylcholine: 47.7 +/- 23.6 sec, nitroglycerine: 53.4 +/- 21.4 sec, p < 0.01). NOx production was reduced until the 1st POD and then recovered. The recovery was more rapid in the MLH group than the other two groups (p < 0.01). The plasma endothelin-1 did not differ among the three groups. These results suggest that endothelial function is impaired during cardiopulmonary bypass with deep hypothermia.
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PMID:Impaired endothelial responses in patients with deep hypothermic cardiopulmonary bypass. 1515 Aug 94